STRINGSTRING
TET2 TET2 LEF1 LEF1 NCOA6 NCOA6 UFL1 UFL1 GPR116 GPR116 JMJD6 JMJD6 LOC102729094 LOC102729094 PLA2G10 PLA2G10 CD109 CD109 ZNF385A ZNF385A NCKAP1L NCKAP1L PDE1B PDE1B IAPP IAPP TREM2 TREM2 LOC102741936 LOC102741936 DCSTAMP DCSTAMP KAT8 KAT8 AHSP AHSP EP300 EP300 JUNB JUNB DNASE2 DNASE2 KLF1 KLF1 SNX10 SNX10 EPB42 EPB42 BAP1 BAP1 CLEC1B CLEC1B CALCR CALCR CREB1 CREB1 SLC25A38 SLC25A38 SRC SRC NKX2-3 NKX2-3 IL20 IL20 DYRK3 DYRK3 IRF4 IRF4 ADAR ADAR GBA GBA F2RL1 F2RL1 PTPN11 PTPN11 ACTN1 ACTN1 LTBR LTBR KCNQ1 KCNQ1 TRAF6 TRAF6 L3MBTL3 L3MBTL3 SRF SRF GAB3 GAB3 UBA5 UBA5 BATF2 BATF2 BCL6 BCL6 JAK2 JAK2 LOC102729240 LOC102729240 PRKX PRKX CD4 CD4 LOC102736784 LOC102736784 GATA1 GATA1 TNF TNF STAT5B STAT5B ERCC2 ERCC2 IL25 IL25 GLO1 GLO1 SLC4A1 SLC4A1 LOC102747288 LOC102747288 JAGN1 JAGN1 HOXB7 HOXB7 KITLG KITLG LOC102747093 LOC102747093 ATP6AP1 ATP6AP1 G6PD G6PD JUN JUN PIR PIR LOC102725922 LOC102725922 HSPA9 HSPA9 IFNG IFNG TOB2 TOB2 LOC102750359 LOC102750359 EPAS1 EPAS1 RB1 RB1 PML PML PAFAH1B1 PAFAH1B1 GATA3 GATA3 LRRK1 LRRK1 CBFB CBFB HSCB HSCB CSF1R CSF1R NRROS NRROS MFHAS1 MFHAS1 FLVCR1 FLVCR1 ETV2 ETV2 LOC102743741 LOC102743741 FASN FASN BATF BATF ZFP36 ZFP36 OSTM1 OSTM1 PTPN2 PTPN2 IRF8 IRF8 TCTA TCTA DLL1 DLL1 DMTN DMTN IL31RA IL31RA CASP3 CASP3 MEF2C MEF2C CDKN2B CDKN2B CDKN2A CDKN2A CSF1 CSF1 FOS FOS ABI1 ABI1 MYH9 MYH9 CCR7 CCR7 CEBPE CEBPE DHRS7B DHRS7B SFRP1 SFRP1 MED1 MED1 EIF2AK1 EIF2AK1 LOC102736516 LOC102736516 LOC102749709 LOC102749709 ZBTB46 ZBTB46 LOC102745103 LOC102745103 LOC102737749 LOC102737749 FARP2 FARP2 NOTCH2 NOTCH2 TRIM10 TRIM10 VPS33B VPS33B CITED2 CITED2 PKNOX1 PKNOX1 SP3 SP3 LOC102740547 LOC102740547 CASP8 CASP8 LOC102747932 LOC102747932 JAK3 JAK3 LOC102732141 LOC102732141 LOC102740057 LOC102740057 NF1 NF1 CAMK4 CAMK4 LOC102726984 LOC102726984 TSPO2 TSPO2 LYAR LYAR LOC102734950 LOC102734950 LOC102729814 LOC102729814 LOC102739673 LOC102739673 ALAS2 ALAS2 CSF2 CSF2 LOC102746856 LOC102746856 LOC102748833 LOC102748833 LOC102744110 LOC102744110 LOC102725591 LOC102725591 LOC102742177 LOC102742177 LOC102749849 LOC102749849 CBFA2T3 CBFA2T3 LOC102727396 LOC102727396 LOC102731864 LOC102731864 LOC102751021 LOC102751021 LOC102730129 LOC102730129 PABPC4 PABPC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TET2Methylcytosine dioxygenase TET2 isoform X2. (2016 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
NCOA6Nuclear receptor coactivator 6 isoform X1. (2046 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
GPR116Probable G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
JMJD6Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1. (414 aa)
LOC102729094Tetraspanin-2-like; Belongs to the tetraspanin (TM4SF) family. (106 aa)
PLA2G10Phospholipase A(2). (163 aa)
CD109CD109 antigen. (1322 aa)
ZNF385AZinc finger protein 385A isoform X1. (386 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
PDE1BPhosphodiesterase. (535 aa)
IAPPIslet amyloid polypeptide. (89 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
DCSTAMPDendritic cell-specific transmembrane protein. (470 aa)
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (458 aa)
AHSPAlpha-hemoglobin-stabilizing protein. (92 aa)
EP300Histone acetyltransferase p300. (2425 aa)
JUNBTranscription factor jun-B. (347 aa)
DNASE2LOW QUALITY PROTEIN: deoxyribonuclease-2-alpha. (365 aa)
KLF1Krueppel-like factor 1. (366 aa)
SNX10Sorting nexin-10. (201 aa)
EPB42Erythrocyte membrane protein band 4.2. (694 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
CLEC1BC-type lectin domain family 1 member B. (228 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (392 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SLC25A38Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (304 aa)
SRCTyrosine-protein kinase. (536 aa)
NKX2-3Homeobox protein Nkx-2.3. (307 aa)
IL20Interleukin-20 isoform X1. (176 aa)
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1. (587 aa)
IRF4Interferon regulatory factor 4 isoform X1. (451 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1145 aa)
GBAGlucosylceramidase. (536 aa)
F2RL1Proteinase-activated receptor 2. (415 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ACTN1Alpha-actinin-1. (406 aa)
LTBRTumor necrosis factor receptor superfamily member 3 isoform X1. (421 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
L3MBTL3Lethal(3)malignant brain tumor-like protein 3 isoform X1. (780 aa)
SRFSerum response factor. (508 aa)
GAB3GRB2-associated-binding protein 3. (507 aa)
UBA5Ubiquitin-like modifier-activating enzyme 5. (404 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2. (275 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
JAK2Tyrosine-protein kinase. (952 aa)
LOC102729240CCAAT/enhancer-binding protein gamma-like. (145 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
LOC102736784Protein G6b isoform X1. (241 aa)
GATA1Erythroid transcription factor. (413 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (661 aa)
IL25Interleukin-25. (169 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
SLC4A1Anion exchange protein. (899 aa)
LOC102747288CCAAT/enhancer-binding protein alpha-like. (178 aa)
JAGN1Protein jagunal homolog 1. (183 aa)
HOXB7Homeobox protein Hox-B7. (83 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
LOC102747093Tetraspanin-2-like; Belongs to the tetraspanin (TM4SF) family. (115 aa)
ATP6AP1V-type proton ATPase subunit S1. (464 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (483 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
PIRPirin. (132 aa)
LOC102725922THO complex subunit 5 homolog. (212 aa)
HSPA9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TOB2Protein Tob2. (335 aa)
LOC102750359Myosin-9-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (163 aa)
EPAS1Endothelial PAS domain-containing protein 1. (865 aa)
RB1Retinoblastoma-associated protein. (846 aa)
PMLProtein PML. (880 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha. (148 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (576 aa)
CBFBCore-binding factor subunit beta isoform X1. (187 aa)
HSCBIron-sulfur cluster co-chaperone protein HscB, mitochondrial. (235 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1-like. (1052 aa)
FLVCR1Feline leukemia virus subgroup C receptor-related protein 1. (556 aa)
ETV2ETS translocation variant 2 isoform X1. (340 aa)
LOC102743741Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
FASNFatty acid synthase. (2519 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
ZFP36Tristetraprolin. (325 aa)
OSTM1Osteopetrosis-associated transmembrane protein 1. (334 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
IRF8Interferon regulatory factor 8. (426 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
DMTNDematin isoform X1. (405 aa)
IL31RAInterleukin-31 receptor subunit alpha-like. (377 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
ABI1Abl interactor 1 isoform X1. (507 aa)
MYH9Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1845 aa)
CCR7c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
DHRS7BDehydrogenase/reductase SDR family member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1. (630 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102749709CCAAT/enhancer-binding protein alpha-like. (165 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46. (318 aa)
LOC102745103DNA-binding protein Ikaros-like. (328 aa)
LOC102737749Transcription factor RelB-like. (167 aa)
FARP2FERM, RhoGEF and pleckstrin domain-containing protein 2. (170 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
TRIM10Tripartite motif-containing protein 10. (481 aa)
VPS33BVacuolar protein sorting-associated protein 33B isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
CITED2Cbp/p300-interacting transactivator 2. (271 aa)
PKNOX1Homeobox protein PKNOX1 isoform X1. (436 aa)
SP3Transcription factor Sp3-like. (751 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC102747932Friend leukemia integration 1 transcription factor-like. (196 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
LOC102732141Iron-responsive element-binding protein 2-like. (229 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
NF1Neurofibromin-like. (1269 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
LOC102726984Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha-like. (135 aa)
TSPO2Translocator protein 2 isoform X1. (171 aa)
LYARCell growth-regulating nucleolar protein-like. (394 aa)
LOC102734950Forkhead box protein P1-like. (351 aa)
LOC102729814Uncharacterized protein C15orf41-like. (165 aa)
LOC102739673lamin-B receptor-like. (348 aa)
ALAS25-aminolevulinate synthase. (587 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
LOC102746856Platelet-activating factor acetylhydrolase IB subunit alpha-like isoform X1. (239 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102744110Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
LOC102725591Alpha-adducin-like. (194 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
LOC102749849Microphthalmia-associated transcription factor-like. (181 aa)
CBFA2T3Protein CBFA2T3-like. (343 aa)
LOC102727396FERM, RhoGEF and pleckstrin domain-containing protein 2-like. (424 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (635 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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