STRINGSTRING
APCDD1 APCDD1 DDX3X DDX3X SFRP5 SFRP5 OTUD5 OTUD5 SFRP4 SFRP4 SOST SOST TRABD2A TRABD2A CTDNEP1 CTDNEP1 TMEM88 TMEM88 LOC102735189 LOC102735189 CCDC88C CCDC88C LOC102730047 LOC102730047 LGR6 LGR6 RSPO1 RSPO1 GLI1 GLI1 CSNK1D CSNK1D TNKS TNKS PIN1 PIN1 BAMBI BAMBI CITED1 CITED1 CSNK1A1 CSNK1A1 HIC1 HIC1 USP8 USP8 TBL1X TBL1X CCAR2 CCAR2 LRRK1 LRRK1 GPR124 GPR124 PFDN5 PFDN5 LOC102730272 LOC102730272 SOX17 SOX17 IFT80 IFT80 GSK3B GSK3B XIAP XIAP LOC102744050 LOC102744050 GSC GSC LOC102747987 LOC102747987 KPNA1 KPNA1 WNT11 WNT11 WNT3A WNT3A WNT3 WNT3 FZD9 FZD9 DACT1 DACT1 LOC102744248 LOC102744248 FOXL1 FOXL1 SULF2 SULF2 LGR5 LGR5 TLE2 TLE2 LOC102727345 LOC102727345 TSKU TSKU HMGXB4 HMGXB4 CTNNBIP1 CTNNBIP1 SHISA2 SHISA2 LOC102728864 LOC102728864 SALL1 SALL1 PPM1B PPM1B TAX1BP3 TAX1BP3 GNB2L1 GNB2L1 SFRP1 SFRP1 LOC102746528 LOC102746528 TRABD2B TRABD2B FZD4 FZD4 USP47 USP47 DKK3 DKK3 TLE3 TLE3 PLEKHA4 PLEKHA4 AMFR AMFR YAP1 YAP1 CSNK1E CSNK1E SOX10 SOX10 TMEM237 TMEM237 LOC102736223 LOC102736223 LOC102745724 LOC102745724 LOC102726750 LOC102726750 MKS1 MKS1 ABL1 ABL1 LOC102730205 LOC102730205 LOC102743045 LOC102743045 FAM53B FAM53B DKKL1 DKKL1 LOC102744093 LOC102744093 CTHRC1 CTHRC1 FERMT1 FERMT1 TMEM198 TMEM198 LOC102742054 LOC102742054 GSK3A GSK3A FGF2 FGF2 RUVBL2 RUVBL2 BMP2 BMP2 ZNF703 ZNF703 SIAH2 SIAH2 DDIT3 DDIT3 LOC102737660 LOC102737660 LOC102732447 LOC102732447 LOC102728905 LOC102728905 GID8 GID8 EMD EMD LOC102740668 LOC102740668 LOC102725974 LOC102725974 LOC102727190 LOC102727190 SPEF1 SPEF1 FRZB FRZB WNT10B WNT10B LOC102741471 LOC102741471 AMER2 AMER2 DKK2 DKK2 LEF1 LEF1 KIAA0922 KIAA0922 SFRP2 SFRP2 LGR4 LGR4 SHISA3 SHISA3 JADE1 JADE1 LOC102733521 LOC102733521 SNAI2 SNAI2 LRRK2 LRRK2 LOC102736212 LOC102736212 FGF9 FGF9 LATS2 LATS2 DEPDC1B DEPDC1B LOC102746429 LOC102746429 WLS WLS CDC73 CDC73 CTNND1 CTNND1 LOC102744579 LOC102744579 RNF220 RNF220 CAV1 CAV1 LOC102750498 LOC102750498 FOXO3 FOXO3 FGF10 FGF10 NOG NOG STK3 STK3 GREM1 GREM1 CAPRIN2 CAPRIN2 RNF146 RNF146 SDHAF2 SDHAF2 NKD1 NKD1 SOX30 SOX30 LOC102732739 LOC102732739 LOC102731342 LOC102731342 NLK NLK SULF1 SULF1 PPM1M PPM1M RSPO2 RSPO2 AXIN1 AXIN1 MBD2 MBD2 LOC102734953 LOC102734953 ILK ILK FAM105B FAM105B LOC102732067 LOC102732067 WWTR1 WWTR1 CCNYL1 CCNYL1 DIXDC1 DIXDC1 BARX1 BARX1 ATP6AP2 ATP6AP2 SRC SRC SOX7 SOX7 ANKRD6 ANKRD6 PTPRO PTPRO ANKRD39 ANKRD39 HHEX HHEX LOC102740678 LOC102740678 FZD7 FZD7 CSNK1G1 CSNK1G1 TNFAIP3 TNFAIP3 RNF43 RNF43 LOC102747957 LOC102747957 LYPD6 LYPD6 EDA EDA STK4 STK4 DKK4 DKK4 PRDM15 PRDM15 LATS1 LATS1 GRB10 GRB10 SOSTDC1 SOSTDC1 LOC102747185 LOC102747185 LOC102732879 LOC102732879 PTK7 PTK7 FRMD8 FRMD8 EGR1 EGR1 NRARP NRARP RUVBL1 RUVBL1 LOC102739809 LOC102739809 HNF1A HNF1A AMER1 AMER1 TMEM170B TMEM170B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APCDD1Protein APCDD1. (461 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
SFRP5Secreted frizzled-related protein 5. (289 aa)
OTUD5OTU domain-containing protein 5 isoform X1. (376 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
SOSTSclerostin. (213 aa)
TRABD2AMetalloprotease TIKI1. (234 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
TMEM88Transmembrane protein 88. (159 aa)
LOC102735189Intraflagellar transport protein 20 homolog. (115 aa)
CCDC88CProtein Daple. (2021 aa)
LOC102730047Tuberin-like. (353 aa)
LGR6Leucine-rich repeat-containing G-protein coupled receptor 6. (853 aa)
RSPO1R-spondin-1. (261 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1105 aa)
CSNK1DCasein kinase I isoform delta isoform X2. (399 aa)
TNKSPoly [ADP-ribose] polymerase. (1328 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (237 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (227 aa)
HIC1Hypermethylated in cancer 1 protein. (560 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X. (522 aa)
CCAR2Cell cycle and apoptosis regulator protein 2. (918 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (576 aa)
GPR124G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1332 aa)
PFDN5Prefoldin subunit 5 isoform X1. (154 aa)
LOC102730272Transducin-like enhancer protein 4-like. (704 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
IFT80Intraflagellar transport protein 80 homolog. (777 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
LOC102744050Protein APCDD1-like. (246 aa)
GSCHomeobox protein goosecoid. (122 aa)
LOC102747987Nephrocystin-4-like. (369 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
DACT1Dapper homolog 1. (523 aa)
LOC102744248Notchless protein homolog 1-like. (151 aa)
FOXL1Forkhead box protein L1. (341 aa)
SULF2N-acetylglucosamine-6-sulfatase. (412 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (598 aa)
TLE2Transducin-like enhancer protein 2 isoform X1. (743 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
TSKUTsukushin. (353 aa)
HMGXB4HMG domain-containing protein 4 isoform X1. (601 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
SHISA2Protein shisa-2 homolog. (295 aa)
LOC102728864R-spondin-4-like. (103 aa)
SALL1Sal-like protein 1-like. (1314 aa)
PPM1BProtein phosphatase 1B isoform X2. (479 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
LOC102746528Metalloprotease TIKI2-like. (301 aa)
TRABD2BMetalloprotease TIKI2. (242 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47; Belongs to the peptidase C19 family. (1287 aa)
DKK3Dickkopf-related protein 3. (286 aa)
TLE3Transducin-like enhancer protein 3-like isoform X5. (726 aa)
PLEKHA4Pleckstrin homology domain-containing family A member 4. (777 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (643 aa)
YAP1Yorkie homolog. (326 aa)
CSNK1ECasein kinase I isoform epsilon isoform X2. (359 aa)
SOX10Transcription factor SOX-10. (469 aa)
TMEM237Transmembrane protein 237. (403 aa)
LOC102736223Ankyrin repeat domain-containing protein 6-like. (284 aa)
LOC102745724Protein APCDD1-like. (268 aa)
LOC102726750myoD family inhibitor-like. (247 aa)
MKS1Meckel syndrome type 1 protein. (262 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
LOC102730205Renin receptor-like. (136 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
FAM53BProtein FAM53B. (426 aa)
DKKL1Dickkopf-like protein 1 isoform X3. (237 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
FERMT1Fermitin family homolog 1-like. (678 aa)
TMEM198Transmembrane protein 198. (360 aa)
LOC102742054Ubiquitin thioesterase ZRANB1-like. (329 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (418 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
ZNF703Zinc finger protein 703-like. (591 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC102737660Leucine-rich repeat-containing G-protein coupled receptor 5-like. (315 aa)
LOC102732447Nucleoredoxin-like. (192 aa)
LOC102728905KN motif and ankyrin repeat domain-containing protein 1-like. (167 aa)
GID8Glucose-induced degradation protein 8 homolog. (228 aa)
EMDEmerin. (260 aa)
LOC102740668RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (335 aa)
LOC102725974KN motif and ankyrin repeat domain-containing protein 1-like. (247 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
SPEF1Sperm flagellar protein 1. (236 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102741471Parafibromin-like. (141 aa)
AMER2APC membrane recruitment protein 2 isoform X1. (688 aa)
DKK2Dickkopf-related protein 2. (259 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
KIAA0922Transmembrane protein 131-like. (1601 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
SHISA3Protein shisa-3 homolog. (238 aa)
JADE1Protein Jade-1 isoform X1. (843 aa)
LOC102733521R-spondin-4-like. (154 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
LOC102736212F-box-like/WD repeat-containing protein TBL1X-like. (344 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
DEPDC1BDEP domain-containing protein 1B isoform X1. (529 aa)
LOC102746429Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (222 aa)
WLSProtein wntless homolog isoform X1. (541 aa)
CDC73Parafibromin. (418 aa)
CTNND1Catenin delta-1 isoform X2. (1022 aa)
LOC102744579Transmembrane protein 198-like. (350 aa)
RNF220E3 ubiquitin-protein ligase RNF220 isoform X1. (566 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
FOXO3Forkhead box protein O3. (672 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
GREM1Gremlin. (184 aa)
CAPRIN2Caprin-2 isoform X1. (1068 aa)
RNF146E3 ubiquitin-protein ligase RNF146 isoform X1. (360 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
NKD1Protein naked cuticle homolog 1. (363 aa)
SOX30Transcription factor SOX-30 isoform X1. (768 aa)
LOC102732739Dickkopf-related protein 1-like. (268 aa)
LOC102731342Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
PPM1MProtein phosphatase 1M. (398 aa)
RSPO2R-spondin-2 isoform X1. (243 aa)
AXIN1Axin-1 isoform X1. (867 aa)
MBD2methyl-CpG-binding domain protein 2. (212 aa)
LOC102734953CXXC-type zinc finger protein 4-like. (198 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
FAM105BUbiquitin thioesterase otulin. (298 aa)
LOC102732067Disabled homolog 2-like isoform X1. (305 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
CCNYL1cyclin-Y-like protein 1 isoform X1; Belongs to the cyclin family. (363 aa)
DIXDC1Dixin isoform X1. (683 aa)
BARX1Homeobox protein BarH-like 1. (282 aa)
ATP6AP2Renin receptor. (100 aa)
SRCTyrosine-protein kinase. (536 aa)
SOX7Transcription factor SOX-7. (386 aa)
ANKRD6Ankyrin repeat domain-containing protein 6-like. (420 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
ANKRD39Ankyrin repeat domain-containing protein 39. (179 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (270 aa)
LOC102740678E3 ubiquitin-protein ligase RNF213-like. (525 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CSNK1G1Casein kinase I isoform gamma-1 isoform X3; Belongs to the protein kinase superfamily. (420 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
RNF43E3 ubiquitin-protein ligase RNF43 isoform X1. (781 aa)
LOC102747957Meckel syndrome type 1 protein-like. (318 aa)
LYPD6ly6/PLAUR domain-containing protein 6. (171 aa)
EDAectodysplasin-A isoform X1; Belongs to the tumor necrosis factor family. (390 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
DKK4Dickkopf-related protein 4. (221 aa)
PRDM15PR domain zinc finger protein 15. (1202 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
SOSTDC1Sclerostin domain-containing protein 1. (208 aa)
LOC102747185Homeobox protein DLX-5-like. (214 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
FRMD8FERM domain-containing protein 8. (457 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (175 aa)
LOC102739809Uncharacterized protein C12orf43 homolog isoform X1. (267 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (631 aa)
AMER1APC membrane recruitment protein 1. (1131 aa)
TMEM170BTransmembrane protein 170B. (121 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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