STRINGSTRING
GRB10 GRB10 FRZB FRZB LOC102727190 LOC102727190 EMD EMD LOC102732447 LOC102732447 DDIT3 DDIT3 SIAH2 SIAH2 BMP2 BMP2 RUVBL2 RUVBL2 GSK3A GSK3A FERMT1 FERMT1 CTHRC1 CTHRC1 LOC102744093 LOC102744093 DKKL1 DKKL1 LOC102743045 LOC102743045 LOC102726750 LOC102726750 LOC102745724 LOC102745724 LOC102736223 LOC102736223 SOX10 SOX10 AMFR AMFR TLE3 TLE3 DKK3 DKK3 FZD4 FZD4 TRABD2B TRABD2B LOC102746528 LOC102746528 SFRP1 SFRP1 GNB2L1 GNB2L1 TAX1BP3 TAX1BP3 SHISA2 SHISA2 CTNNBIP1 CTNNBIP1 HMGXB4 HMGXB4 TSKU TSKU LOC102727345 LOC102727345 TLE2 TLE2 DACT1 DACT1 WNT11 WNT11 LOC102747987 LOC102747987 GSC GSC LOC102744050 LOC102744050 GSK3B GSK3B IFT80 IFT80 SOX17 SOX17 LOC102730272 LOC102730272 PFDN5 PFDN5 HIC1 HIC1 CSNK1A1 CSNK1A1 CITED1 CITED1 GLI1 GLI1 LOC102730047 LOC102730047 CCDC88C CCDC88C TMEM88 TMEM88 TRABD2A TRABD2A SOST SOST SFRP4 SFRP4 OTUD5 OTUD5 SFRP5 SFRP5 APCDD1 APCDD1 AMER2 AMER2 TMEM170B TMEM170B AMER1 AMER1 LOC102739809 LOC102739809 EGR1 EGR1 FRMD8 FRMD8 LOC102732879 LOC102732879 SOSTDC1 SOSTDC1 LATS1 LATS1 DKK4 DKK4 STK4 STK4 RNF43 RNF43 LOC102740678 LOC102740678 PTPRO PTPRO ANKRD6 ANKRD6 BARX1 BARX1 WWTR1 WWTR1 LOC102732067 LOC102732067 LOC102734953 LOC102734953 AXIN1 AXIN1 NLK NLK LOC102731342 LOC102731342 LOC102732739 LOC102732739 SOX30 SOX30 NKD1 NKD1 SDHAF2 SDHAF2 GREM1 GREM1 STK3 STK3 NOG NOG FOXO3 FOXO3 CAV1 CAV1 CTNND1 CTNND1 LOC102746429 LOC102746429 LATS2 LATS2 FGF9 FGF9 SNAI2 SNAI2 JADE1 JADE1 SHISA3 SHISA3 SFRP2 SFRP2 KIAA0922 KIAA0922 DKK2 DKK2
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB10Growth factor receptor-bound protein 10. (586 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
EMDEmerin. (260 aa)
LOC102732447Nucleoredoxin-like. (192 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (418 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
FERMT1Fermitin family homolog 1-like. (678 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
DKKL1Dickkopf-like protein 1 isoform X3. (237 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
LOC102726750myoD family inhibitor-like. (247 aa)
LOC102745724Protein APCDD1-like. (268 aa)
LOC102736223Ankyrin repeat domain-containing protein 6-like. (284 aa)
SOX10Transcription factor SOX-10. (469 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (643 aa)
TLE3Transducin-like enhancer protein 3-like isoform X5. (726 aa)
DKK3Dickkopf-related protein 3. (286 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
TRABD2BMetalloprotease TIKI2. (242 aa)
LOC102746528Metalloprotease TIKI2-like. (301 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
SHISA2Protein shisa-2 homolog. (295 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
HMGXB4HMG domain-containing protein 4 isoform X1. (601 aa)
TSKUTsukushin. (353 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
TLE2Transducin-like enhancer protein 2 isoform X1. (743 aa)
DACT1Dapper homolog 1. (523 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LOC102747987Nephrocystin-4-like. (369 aa)
GSCHomeobox protein goosecoid. (122 aa)
LOC102744050Protein APCDD1-like. (246 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IFT80Intraflagellar transport protein 80 homolog. (777 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
LOC102730272Transducin-like enhancer protein 4-like. (704 aa)
PFDN5Prefoldin subunit 5 isoform X1. (154 aa)
HIC1Hypermethylated in cancer 1 protein. (560 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (227 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X2. (197 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1105 aa)
LOC102730047Tuberin-like. (353 aa)
CCDC88CProtein Daple. (2021 aa)
TMEM88Transmembrane protein 88. (159 aa)
TRABD2AMetalloprotease TIKI1. (234 aa)
SOSTSclerostin. (213 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
OTUD5OTU domain-containing protein 5 isoform X1. (376 aa)
SFRP5Secreted frizzled-related protein 5. (289 aa)
APCDD1Protein APCDD1. (461 aa)
AMER2APC membrane recruitment protein 2 isoform X1. (688 aa)
TMEM170BTransmembrane protein 170B. (121 aa)
AMER1APC membrane recruitment protein 1. (1131 aa)
LOC102739809Uncharacterized protein C12orf43 homolog isoform X1. (267 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
FRMD8FERM domain-containing protein 8. (457 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
SOSTDC1Sclerostin domain-containing protein 1. (208 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
DKK4Dickkopf-related protein 4. (221 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
RNF43E3 ubiquitin-protein ligase RNF43 isoform X1. (781 aa)
LOC102740678E3 ubiquitin-protein ligase RNF213-like. (525 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1216 aa)
ANKRD6Ankyrin repeat domain-containing protein 6-like. (420 aa)
BARX1Homeobox protein BarH-like 1. (282 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
LOC102732067Disabled homolog 2-like isoform X1. (305 aa)
LOC102734953CXXC-type zinc finger protein 4-like. (198 aa)
AXIN1Axin-1 isoform X1. (867 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
LOC102731342Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
LOC102732739Dickkopf-related protein 1-like. (268 aa)
SOX30Transcription factor SOX-30 isoform X1. (768 aa)
NKD1Protein naked cuticle homolog 1. (363 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
GREM1Gremlin. (184 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXO3Forkhead box protein O3. (672 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CTNND1Catenin delta-1 isoform X2. (1022 aa)
LOC102746429Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (222 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
JADE1Protein Jade-1 isoform X1. (843 aa)
SHISA3Protein shisa-3 homolog. (238 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
KIAA0922Transmembrane protein 131-like. (1601 aa)
DKK2Dickkopf-related protein 2. (259 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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