(21 nodes) Macrophage differentiation network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	CSF2	Granulocyte-macrophage colony-stimulating factor. (153 aa)
	LOC102729094	Tetraspanin-2-like; Belongs to the tetraspanin (TM4SF) family. (106 aa)
	NKX2-3	Homeobox protein Nkx-2.3. (307 aa)
	GBA	Glucosylceramidase. (536 aa)
	L3MBTL3	Lethal(3)malignant brain tumor-like protein 3 isoform X1. (780 aa)
	GAB3	GRB2-associated-binding protein 3. (507 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	LOC102747288	CCAAT/enhancer-binding protein alpha-like. (178 aa)
	LOC102747093	Tetraspanin-2-like; Belongs to the tetraspanin (TM4SF) family. (115 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	LOC102730129	Uncharacterized protein LOC102730129. (471 aa)
	NRROS	Negative regulator of reactive oxygen species. (691 aa)
	LOC102743741	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
	CEBPE	CCAAT/enhancer-binding protein. (281 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1. (630 aa)
	LOC102749709	CCAAT/enhancer-binding protein alpha-like. (165 aa)
	ZBTB46	Zinc finger and BTB domain-containing protein 46. (318 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	LOC102740057	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	CD4	A0A2U3Z0R6	A0A2U3Y2Q1	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	T-cell surface glycoprotein CD4.	0.439
CASP8	IFNG	A0A2U3Z0R6	A0A2U3Y8N2	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.493
CD4	CASP8	A0A2U3Y2Q1	A0A2U3Z0R6	T-cell surface glycoprotein CD4.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.439
CD4	CSF1	A0A2U3Y2Q1	A0A2U3YQ02	T-cell surface glycoprotein CD4.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.531
CD4	CSF2	A0A2U3Y2Q1	A0A2U3Z5Z5	T-cell surface glycoprotein CD4.	Granulocyte-macrophage colony-stimulating factor.	0.736
CD4	IFNG	A0A2U3Y2Q1	A0A2U3Y8N2	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.891
CD4	LOC102743741	A0A2U3Y2Q1	A0A2U3YH28	T-cell surface glycoprotein CD4.	Interleukin; Belongs to the IL-15/IL-21 family.	0.744
CSF1	CD4	A0A2U3YQ02	A0A2U3Y2Q1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	T-cell surface glycoprotein CD4.	0.531
CSF1	CSF2	A0A2U3YQ02	A0A2U3Z5Z5	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Granulocyte-macrophage colony-stimulating factor.	0.861
CSF1	IFNG	A0A2U3YQ02	A0A2U3Y8N2	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.699
CSF1	LOC102743741	A0A2U3YQ02	A0A2U3YH28	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interleukin; Belongs to the IL-15/IL-21 family.	0.551
CSF2	CD4	A0A2U3Z5Z5	A0A2U3Y2Q1	Granulocyte-macrophage colony-stimulating factor.	T-cell surface glycoprotein CD4.	0.736
CSF2	CSF1	A0A2U3Z5Z5	A0A2U3YQ02	Granulocyte-macrophage colony-stimulating factor.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.861
CSF2	IFNG	A0A2U3Z5Z5	A0A2U3Y8N2	Granulocyte-macrophage colony-stimulating factor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.839
CSF2	LOC102743741	A0A2U3Z5Z5	A0A2U3YH28	Granulocyte-macrophage colony-stimulating factor.	Interleukin; Belongs to the IL-15/IL-21 family.	0.700
IFNG	CASP8	A0A2U3Y8N2	A0A2U3Z0R6	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.493
IFNG	CD4	A0A2U3Y8N2	A0A2U3Y2Q1	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	T-cell surface glycoprotein CD4.	0.891
IFNG	CSF1	A0A2U3Y8N2	A0A2U3YQ02	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.699
IFNG	CSF2	A0A2U3Y8N2	A0A2U3Z5Z5	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Granulocyte-macrophage colony-stimulating factor.	0.839
IFNG	LOC102743741	A0A2U3Y8N2	A0A2U3YH28	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin; Belongs to the IL-15/IL-21 family.	0.866