(12 nodes) Male sex determination network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR5A2	Nuclear receptor subfamily 5 group A member 2-like isoform X1. (541 aa)
	LOC102729919	Transcription factor SOX-2-like. (322 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1605 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (393 aa)
	INSRR	Tyrosine-protein kinase receptor. (1380 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	LOC102733831	Transcription factor SOX-3-like. (82 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	DHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	DMRT1	Doublesex- and mab-3-related transcription factor 1. (288 aa)
	LOC102740573	Transcription factor SOX-3-like. (215 aa)
	SIX4	Homeobox protein SIX4. (778 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHH	DMRT1	A0A2U3XDA5	A0A2U3Z453	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Doublesex- and mab-3-related transcription factor 1.	0.492
DHH	FGF9	A0A2U3XDA5	A0A2U3X8U2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.553
DHH	LOC102727345	A0A2U3XDA5	A0A2U3YND0	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Transcription factor SOX-9-like.	0.640
DHH	NR5A2	A0A2U3XDA5	A0A2U3XE63	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Nuclear receptor subfamily 5 group A member 2-like isoform X1.	0.424
DMRT1	DHH	A0A2U3Z453	A0A2U3XDA5	Doublesex- and mab-3-related transcription factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.492
DMRT1	FGF9	A0A2U3Z453	A0A2U3X8U2	Doublesex- and mab-3-related transcription factor 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.487
DMRT1	LOC102727345	A0A2U3Z453	A0A2U3YND0	Doublesex- and mab-3-related transcription factor 1.	Transcription factor SOX-9-like.	0.686
DMRT1	LOC102729919	A0A2U3Z453	A0A2U3XIJ2	Doublesex- and mab-3-related transcription factor 1.	Transcription factor SOX-2-like.	0.432
DMRT1	LOC102733831	A0A2U3Z453	A0A2U3XAG0	Doublesex- and mab-3-related transcription factor 1.	Transcription factor SOX-3-like.	0.432
DMRT1	LOC102740573	A0A2U3Z453	A0A2U3Z6J2	Doublesex- and mab-3-related transcription factor 1.	Transcription factor SOX-3-like.	0.432
DMRT1	NR5A2	A0A2U3Z453	A0A2U3XE63	Doublesex- and mab-3-related transcription factor 1.	Nuclear receptor subfamily 5 group A member 2-like isoform X1.	0.501
FGF9	DHH	A0A2U3X8U2	A0A2U3XDA5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.553
FGF9	DMRT1	A0A2U3X8U2	A0A2U3Z453	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Doublesex- and mab-3-related transcription factor 1.	0.487
FGF9	INSRR	A0A2U3X8U2	A0A2U3YKS4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase receptor.	0.813
FGF9	LOC102727345	A0A2U3X8U2	A0A2U3YND0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transcription factor SOX-9-like.	0.552
INSRR	FGF9	A0A2U3YKS4	A0A2U3X8U2	Tyrosine-protein kinase receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.813
LOC102727345	DHH	A0A2U3YND0	A0A2U3XDA5	Transcription factor SOX-9-like.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.640
LOC102727345	DMRT1	A0A2U3YND0	A0A2U3Z453	Transcription factor SOX-9-like.	Doublesex- and mab-3-related transcription factor 1.	0.686
LOC102727345	FGF9	A0A2U3YND0	A0A2U3X8U2	Transcription factor SOX-9-like.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.552
LOC102727345	NR5A2	A0A2U3YND0	A0A2U3XE63	Transcription factor SOX-9-like.	Nuclear receptor subfamily 5 group A member 2-like isoform X1.	0.749