(19 nodes) Negative regulation of ossification network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA1	Erythroid transcription factor. (413 aa)
	BCOR	BCL-6 corepressor isoform X1. (1757 aa)
	CALCR	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (392 aa)
	GREM1	Gremlin. (184 aa)
	SRGN	Serglycin. (155 aa)
	ECM1	LOW QUALITY PROTEIN: extracellular matrix protein 1. (550 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)
	KREMEN2	Kremen protein 2-like. (307 aa)
	FGF23	Fibroblast growth factor 23. (177 aa)
	LOC102750017	Mothers against decapentaplegic homolog 6-like. (181 aa)
	SFRP1	Secreted frizzled-related protein 1. (303 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	MEF2C	Myocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
	FAM101B	Protein FAM101B. (149 aa)
	AHSG	alpha-2-HS-glycoprotein isoform X1. (364 aa)
	LTBP3	Latent-transforming growth factor beta-binding protein 3-like. (1159 aa)
	SOST	Sclerostin. (213 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X1. (823 aa)
	LOC102726900	Mothers against decapentaplegic homolog 7-like. (178 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSG	FGF23	A0A2U3YHU3	A0A2U3Z274	alpha-2-HS-glycoprotein isoform X1.	Fibroblast growth factor 23.	0.471
FGF23	AHSG	A0A2U3Z274	A0A2U3YHU3	Fibroblast growth factor 23.	alpha-2-HS-glycoprotein isoform X1.	0.471
FGF23	SOST	A0A2U3Z274	A0A2U3Y568	Fibroblast growth factor 23.	Sclerostin.	0.821
HIF1A	LOC102727345	A0A2U3Y4G5	A0A2U3YND0	Hypoxia-inducible factor 1-alpha isoform X1.	Transcription factor SOX-9-like.	0.527
LOC102726900	LOC102750017	A0A2U3XYM0	A0A2U3Z1Z6	Mothers against decapentaplegic homolog 7-like.	Mothers against decapentaplegic homolog 6-like.	0.987
LOC102727345	HIF1A	A0A2U3YND0	A0A2U3Y4G5	Transcription factor SOX-9-like.	Hypoxia-inducible factor 1-alpha isoform X1.	0.527
LOC102727345	MEF2C	A0A2U3YND0	A0A2U3YMC3	Transcription factor SOX-9-like.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.498
LOC102750017	LOC102726900	A0A2U3Z1Z6	A0A2U3XYM0	Mothers against decapentaplegic homolog 6-like.	Mothers against decapentaplegic homolog 7-like.	0.987
LOC102750030	MEF2C	A0A2U3Z8N4	A0A2U3YMC3	Protein-tyrosine kinase 2-beta-like.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.697
MEF2C	LOC102727345	A0A2U3YMC3	A0A2U3YND0	Myocyte-specific enhancer factor 2C-like isoform X2.	Transcription factor SOX-9-like.	0.498
MEF2C	LOC102750030	A0A2U3YMC3	A0A2U3Z8N4	Myocyte-specific enhancer factor 2C-like isoform X2.	Protein-tyrosine kinase 2-beta-like.	0.697
SFRP1	SOST	A0A2U3YST4	A0A2U3Y568	Secreted frizzled-related protein 1.	Sclerostin.	0.589
SOST	FGF23	A0A2U3Y568	A0A2U3Z274	Sclerostin.	Fibroblast growth factor 23.	0.821
SOST	SFRP1	A0A2U3Y568	A0A2U3YST4	Sclerostin.	Secreted frizzled-related protein 1.	0.589