STRINGSTRING
PML PML CIRBP CIRBP RB1 RB1 SEMA7A SEMA7A CCDC85B CCDC85B LOC102746290 LOC102746290 SESN2 SESN2 OSGIN1 OSGIN1 DNAJB2 DNAJB2 PLXNA3 PLXNA3 CRLF3 CRLF3 TP53 TP53 TGFB2 TGFB2 DDX3X DDX3X MUL1 MUL1 OSTN OSTN SEMA3F SEMA3F BCL6 BCL6 MYL2 MYL2 RYK RYK LOC102730452 LOC102730452 RBBP7 RBBP7 SMARCA2 SMARCA2 LOC102751226 LOC102751226 TP53TG5 TP53TG5 LOC102735085 LOC102735085 ADAM15 ADAM15 SMAD4 SMAD4 GDF9 GDF9 BMPR2 BMPR2 HNF4A HNF4A SEMA4C SEMA4C RERG RERG NME6 NME6 IP6K2 IP6K2 CDKN1B CDKN1B DCBLD2 DCBLD2 CDKN2C CDKN2C SEMA3G SEMA3G SPG20 SPG20 CDKL3 CDKL3 GREM1 GREM1 LOC102732138 LOC102732138 CDKN2D CDKN2D DCSTAMP DCSTAMP OSGIN2 OSGIN2 PTPRJ PTPRJ ST7L ST7L SEMA6C SEMA6C GJA1 GJA1 SEMA6D SEMA6D SFRP2 SFRP2 SEMA3C SEMA3C SEMA3A SEMA3A SEMA3D SEMA3D LOC102729898 LOC102729898 NTN1 NTN1 SEMA4A SEMA4A FRZB FRZB SEMA6B SEMA6B LOC102736634 LOC102736634 PPP1R9B PPP1R9B LOC102749531 LOC102749531 LOC102740049 LOC102740049 WT1 WT1 CDKN2AIP CDKN2AIP LOC102730318 LOC102730318 GSK3A GSK3A IFRD2 IFRD2 SEMA3B SEMA3B SEMA5B SEMA5B CDKN1A CDKN1A LOC102743583 LOC102743583 LOC102727190 LOC102727190 CDK5 CDK5 SOX17 SOX17 CGRRF1 CGRRF1 WNT11 WNT11 SERTAD1 SERTAD1 SERTAD3 SERTAD3 ACVRL1 ACVRL1 WNT3A WNT3A WNT3 WNT3 CCAR2 CCAR2 PSRC1 PSRC1 SEMA5A SEMA5A MSX1 MSX1 FBP1 FBP1 YJEFN3 YJEFN3 FLCN FLCN NDUFA13 NDUFA13 SEMA6A SEMA6A SPHK2 SPHK2 DCUN1D3 DCUN1D3 GNG4 GNG4 RTN4R RTN4R SEMA4G SEMA4G GNB2L1 GNB2L1 KIAA1024 KIAA1024 SFRP1 SFRP1 NOV NOV TGFB1 TGFB1 INHBA INHBA CDHR2 CDHR2 LOC102732425 LOC102732425
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMLProtein PML. (880 aa)
CIRBPCold-inducible RNA-binding protein isoform X2. (172 aa)
RB1Retinoblastoma-associated protein. (846 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
CCDC85BCoiled-coil domain-containing protein 85B. (202 aa)
LOC10274629025-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; Belongs to the cytochrome P450 family. (508 aa)
SESN2Sestrin-2. (481 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (478 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X2. (278 aa)
PLXNA3plexin-A3. (1452 aa)
CRLF3Cytokine receptor-like factor 3. (438 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
OSTNOsteocrin. (132 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (786 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
RYKTyrosine-protein kinase RYK. (475 aa)
LOC102730452semaphorin-4A-like; Belongs to the semaphorin family. (436 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
SMARCA2Probable global transcription activator SNF2L2 isoform X1. (278 aa)
LOC102751226Peptidase inhibitor 16-like. (304 aa)
TP53TG5LOW QUALITY PROTEIN: TP53-target gene 5 protein. (278 aa)
LOC102735085semaphorin-4F-like; Belongs to the semaphorin family. (449 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (867 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF9Growth/differentiation factor 9. (453 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
HNF4AHepatocyte nuclear factor 4-alpha. (399 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
RERGRas-related and estrogen-regulated growth inhibitor isoform X1. (199 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
DCBLD2Discoidin, CUB and LCCL domain-containing protein 2. (776 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (770 aa)
SPG20Spartin isoform X1. (691 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (590 aa)
GREM1Gremlin. (184 aa)
LOC102732138Testis-specific Y-encoded-like protein 2-like; Belongs to the nucleosome assembly protein (NAP) family. (451 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D isoform X2. (166 aa)
DCSTAMPDendritic cell-specific transmembrane protein. (470 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2. (549 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1218 aa)
ST7LSuppressor of tumorigenicity 7 protein-like. (499 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (963 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
SEMA6Dsemaphorin-6D-like isoform X3; Belongs to the semaphorin family. (1017 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (696 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3DLOW QUALITY PROTEIN: semaphorin-3D; Belongs to the semaphorin family. (781 aa)
LOC102729898NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like; Belongs to the complex I 30 kDa subunit family. (162 aa)
NTN1Netrin-1-like. (402 aa)
SEMA4Asemaphorin-4A-like. (350 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (673 aa)
LOC102736634NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like. (132 aa)
PPP1R9BNeurabin-2. (819 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
LOC102740049Testis-specific Y-encoded-like protein 2-like; Belongs to the nucleosome assembly protein (NAP) family. (278 aa)
WT1Wilms tumor protein-like. (413 aa)
CDKN2AIPCDKN2A-interacting protein. (582 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
IFRD2Interferon-related developmental regulator 2 isoform X2. (441 aa)
SEMA3Bsemaphorin-3B. (166 aa)
SEMA5Bsemaphorin-5B-like. (989 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102743583Nuclear apoptosis-inducing factor 1-like. (327 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
CGRRF1Cell growth regulator with RING finger domain protein 1. (332 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SERTAD1SERTA domain-containing protein 1 isoform X1. (237 aa)
SERTAD3SERTA domain-containing protein 3. (198 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
CCAR2Cell cycle and apoptosis regulator protein 2. (918 aa)
PSRC1Proline/serine-rich coiled-coil protein 1. (303 aa)
SEMA5Asemaphorin-5A-like. (1034 aa)
MSX1Homeobox protein MSX-1. (303 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (250 aa)
FLCNFolliculin. (579 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
DCUN1D3DCN1-like protein. (304 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RTN4RReticulon-4 receptor. (528 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (840 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
KIAA1024UPF0258 protein KIAA1024 homolog. (832 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
NOVProtein NOV homolog. (353 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
INHBAInhibin beta A chain. (424 aa)
CDHR2Cadherin-related family member 2. (1308 aa)
LOC102732425Myelin-associated glycoprotein-like. (382 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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