STRINGSTRING
FOXJ2 FOXJ2 JAG1 JAG1 OSR1 OSR1 HOXA7 HOXA7 EZH2 EZH2 FGF10 FGF10 CAV1 CAV1 KRAS KRAS LOC102740025 LOC102740025 FRZB FRZB LOC102733867 LOC102733867 YAP1 YAP1 NKX6-3 NKX6-3 NODAL NODAL LOC102727345 LOC102727345 DLL1 DLL1 ACVRL1 ACVRL1 LOC102745380 LOC102745380 SPRY1 SPRY1 TBX3 TBX3 FST FST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXJ2Forkhead box protein J2. (572 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
OSR1Protein odd-skipped-related 1 isoform X1. (267 aa)
HOXA7Homeobox protein Hox-A7. (235 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
LOC102733867Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
YAP1Yorkie homolog. (326 aa)
NKX6-3Homeobox protein Nkx-6.3. (263 aa)
NODALNodal homolog. (348 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
TBX3T-box transcription factor TBX3. (675 aa)
FSTFollistatin isoform X1. (344 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: medium (46%) [HD]