STRINGSTRING
SEZ6L2 SEZ6L2 ITGB1 ITGB1 OGDH OGDH TBR1 TBR1 PTPN11 PTPN11 LOC102750621 LOC102750621 EGR2 EGR2 GBA GBA LOC102748757 LOC102748757 LOC102744942 LOC102744942 SEMA4C SEMA4C GRID2 GRID2 OTX1 OTX1 LOC102738565 LOC102738565 LHX1 LHX1 RPGRIP1L RPGRIP1L KLHL5 KLHL5 HOXA2 HOXA2 LOC102732851 LOC102732851 LOC102726171 LOC102726171 EZH2 EZH2 CBLN1 CBLN1 NOG NOG DLL1 DLL1 CRKL CRKL NHLH2 NHLH2 RBFOX2 RBFOX2 EN1 EN1 FZD4 FZD4 SKOR2 SKOR2 ABL1 ABL1 KDM2B KDM2B CBS CBS LOC102745732 LOC102745732 B4GALT2 B4GALT2 GBX2 GBX2 FGF2 FGF2 ZNF423 ZNF423 ADCK4 ADCK4 LOC102726777 LOC102726777 CDK5 CDK5 LOC102734560 LOC102734560 LOC102749599 LOC102749599 ATF5 ATF5 HSPA5 HSPA5 ALDH1A2 ALDH1A2 SMAD1 SMAD1 KCNE1 KCNE1 NHLH1 NHLH1 LOC102745380 LOC102745380 ZNF365 ZNF365 LHX5 LHX5 ATF2 ATF2 CEND1 CEND1 GNPAT GNPAT ARCN1 ARCN1 CRK CRK PHOX2B PHOX2B PTF1A PTF1A WNT1 WNT1 FAIM2 FAIM2 EN2 EN2 ARL13B ARL13B CLP1 CLP1 CNTN1 CNTN1 LRRC1 LRRC1 KLHL4 KLHL4 KLHL1 KLHL1 SEC24B SEC24B LEF1 LEF1 LOC102726335 LOC102726335 GLI1 GLI1 MECP2 MECP2 HOXB2 HOXB2 HOXB1 HOXB1 HOXB3 HOXB3 TP53 TP53 ATP1B2 ATP1B2 KAT2A KAT2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEZ6L2Seizure 6-like protein 2 isoform X1. (923 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
OGDH2-oxoglutarate dehydrogenase, mitochondrial isoform X1. (1038 aa)
TBR1T-box brain protein 1. (682 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
LOC102750621Oligophrenin-1-like. (685 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
GBAGlucosylceramidase. (536 aa)
LOC102748757Cytochrome b-c1 complex subunit 8-like isoform X1. (82 aa)
LOC102744942Arginine-glutamic acid dipeptide repeats protein-like. (996 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
GRID2Glutamate receptor ionotropic, delta-2. (211 aa)
OTX1Homeobox protein OTX1. (354 aa)
LOC102738565Protein lifeguard 1-like. (378 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
RPGRIP1LProtein fantom isoform X2. (1244 aa)
KLHL5Kelch-like protein 5 isoform X1. (708 aa)
HOXA2Homeobox protein Hox-A2. (376 aa)
LOC102732851LIM domain-binding protein 1-like. (227 aa)
LOC102726171LIM domain-binding protein 1-like. (190 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
CBLN1Cerebellin-1. (193 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
CRKLCrk-like protein. (303 aa)
NHLH2Helix-loop-helix protein 2. (135 aa)
RBFOX2RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (376 aa)
EN1Homeobox protein engrailed-like. (305 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SKOR2SKI family transcriptional corepressor 2. (296 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
KDM2BLysine-specific demethylase 2B. (637 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (572 aa)
LOC102745732Leucine-rich repeat-containing protein 1-like. (92 aa)
B4GALT2Beta-1,4-galactosyltransferase 2 isoform X1. (369 aa)
GBX2Homeobox protein GBX-2. (251 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
ZNF423Zinc finger protein 423-like. (1075 aa)
ADCK4Uncharacterized aarF domain-containing protein kinase 4. (525 aa)
LOC102726777Cyclin-dependent kinase 5 activator 2-like. (98 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
LOC102734560plexin-A2-like. (296 aa)
LOC102749599Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (420 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (280 aa)
HSPA578 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1 isoform X2. (124 aa)
NHLH1Helix-loop-helix protein 1. (133 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
ZNF365Protein ZNF365. (407 aa)
LHX5LIM/homeobox protein Lhx5. (402 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
CEND1Cell cycle exit and neuronal differentiation protein 1. (148 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (679 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (511 aa)
CRKAdapter molecule crk. (92 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
PTF1APancreas transcription factor 1 subunit alpha. (156 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (315 aa)
EN2Homeobox protein engrailed-like. (224 aa)
ARL13BADP-ribosylation factor-like protein 13B isoform X1. (430 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
CNTN1Contactin-1-like isoform X1. (1018 aa)
LRRC1Leucine-rich repeat-containing protein 1. (242 aa)
KLHL4LOW QUALITY PROTEIN: kelch-like protein 4. (718 aa)
KLHL1Kelch-like protein 1-like. (678 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1258 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
LOC102726335Glutamate receptor ionotropic, delta-2-like isoform X1. (787 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1105 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (499 aa)
HOXB2Homeobox protein Hox-B2. (349 aa)
HOXB1Homeobox protein Hox-B1. (304 aa)
HOXB3Homeobox protein Hox-B3. (211 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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