(24 nodes) Endocrine pancreas development network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	PDX1	Pancreas/duodenum homeobox protein 1. (283 aa)
	PAX4	LOW QUALITY PROTEIN: paired box 4. (384 aa)
	LOC102736146	3-phosphoinositide-dependent protein kinase 1-like. (216 aa)
	MNX1	Motor neuron and pancreas homeobox protein 1. (260 aa)
	LOC102746665	SID1 transmembrane family member 2-like. (244 aa)
	LOC102743139	SID1 transmembrane family member 2-like. (615 aa)
	BMP6	Bone morphogenetic protein 6. (189 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	NKX6-2	Homeobox protein Nkx-6.2. (168 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1114 aa)
	FOXA2	Hepatocyte nuclear factor 3-beta-like. (465 aa)
	GIPR	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (330 aa)
	NKX6-1	Homeobox protein Nkx-6.1-like. (366 aa)
	ONECUT2	One cut domain family member. (430 aa)
	LOC102738400	Annexin. (345 aa)
	RFX6	DNA-binding protein RFX6. (928 aa)
	HNF4A	Hepatocyte nuclear factor 4-alpha. (399 aa)
	GATA6	Transcription factor GATA-6. (287 aa)
	LOC102737670	Cyclin-dependent kinase 6-like. (322 aa)
	PAX6	Paired box protein Pax-6. (221 aa)
	GDF11	Growth/differentiation factor 11. (372 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (454 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP5	LOC102740547	A0A2U3XA39	A0A2U3Z034	Bone morphogenetic protein 5 isoform X2.	Bone morphogenetic protein 4-like isoform X1.	0.650
BMP6	LOC102727345	A0A2U3YPC2	A0A2U3YND0	Bone morphogenetic protein 6.	Transcription factor SOX-9-like.	0.479
BMP6	LOC102740547	A0A2U3YPC2	A0A2U3Z034	Bone morphogenetic protein 6.	Bone morphogenetic protein 4-like isoform X1.	0.944
EIF2AK3	RFX6	A0A2U3YBY0	A0A2U3XT78	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	DNA-binding protein RFX6.	0.404
FOXA2	GATA6	A0A2U3YBS9	A0A2U3XNQ5	Hepatocyte nuclear factor 3-beta-like.	Transcription factor GATA-6.	0.876
FOXA2	HNF4A	A0A2U3YBS9	A0A2U3XSW6	Hepatocyte nuclear factor 3-beta-like.	Hepatocyte nuclear factor 4-alpha.	0.438
FOXA2	LOC102727345	A0A2U3YBS9	A0A2U3YND0	Hepatocyte nuclear factor 3-beta-like.	Transcription factor SOX-9-like.	0.570
FOXA2	LOC102740547	A0A2U3YBS9	A0A2U3Z034	Hepatocyte nuclear factor 3-beta-like.	Bone morphogenetic protein 4-like isoform X1.	0.739
FOXA2	MNX1	A0A2U3YBS9	A0A2U3Z5W6	Hepatocyte nuclear factor 3-beta-like.	Motor neuron and pancreas homeobox protein 1.	0.602
FOXA2	NKX6-1	A0A2U3YBS9	A0A2U3Y2Y4	Hepatocyte nuclear factor 3-beta-like.	Homeobox protein Nkx-6.1-like.	0.677
FOXA2	PAX4	A0A2U3YBS9	A0A2U3Z8T7	Hepatocyte nuclear factor 3-beta-like.	LOW QUALITY PROTEIN: paired box 4.	0.517
FOXA2	PAX6	A0A2U3YBS9	A0A2U3XCB4	Hepatocyte nuclear factor 3-beta-like.	Paired box protein Pax-6.	0.810
FOXA2	PDX1	A0A2U3YBS9	A0A2U3YYZ7	Hepatocyte nuclear factor 3-beta-like.	Pancreas/duodenum homeobox protein 1.	0.715
FOXA2	RFX6	A0A2U3YBS9	A0A2U3XT78	Hepatocyte nuclear factor 3-beta-like.	DNA-binding protein RFX6.	0.540
GATA6	FOXA2	A0A2U3XNQ5	A0A2U3YBS9	Transcription factor GATA-6.	Hepatocyte nuclear factor 3-beta-like.	0.876
GATA6	LOC102727345	A0A2U3XNQ5	A0A2U3YND0	Transcription factor GATA-6.	Transcription factor SOX-9-like.	0.512
GATA6	LOC102740547	A0A2U3XNQ5	A0A2U3Z034	Transcription factor GATA-6.	Bone morphogenetic protein 4-like isoform X1.	0.593
GATA6	PAX6	A0A2U3XNQ5	A0A2U3XCB4	Transcription factor GATA-6.	Paired box protein Pax-6.	0.542
HNF4A	FOXA2	A0A2U3XSW6	A0A2U3YBS9	Hepatocyte nuclear factor 4-alpha.	Hepatocyte nuclear factor 3-beta-like.	0.438
LOC102727345	BMP6	A0A2U3YND0	A0A2U3YPC2	Transcription factor SOX-9-like.	Bone morphogenetic protein 6.	0.479