STRINGSTRING
FGF10 FGF10 LOC102744822 LOC102744822 BMP2 BMP2 FGF2 FGF2 LOC102737253 LOC102737253 WNT2B WNT2B LOC102740547 LOC102740547 LOC102727345 LOC102727345 LOC102728858 LOC102728858 SPRY1 SPRY1 NKX2-1 NKX2-1 SOX8 SOX8 LOC102739809 LOC102739809 HIPK2 HIPK2 NKX2-2 NKX2-2 LOC102725595 LOC102725595 HOXA11 HOXA11 WNT1 WNT1 HOXC11 HOXC11 HIPK1 HIPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102737253Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
LOC102728858Fibroblast growth factor receptor substrate 2-like; Belongs to the TCP-1 chaperonin family. (251 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
NKX2-1Homeobox protein Nkx-2.1. (252 aa)
SOX8Transcription factor SOX-8. (412 aa)
LOC102739809Uncharacterized protein C12orf43 homolog isoform X1. (267 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
LOC102725595Fibroblast growth factor receptor substrate 2-like. (316 aa)
HOXA11Homeobox protein Hox-A11. (321 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HOXC11Homeobox protein Hox-C11. (304 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X2. (1080 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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