STRINGSTRING
SOX17 SOX17 TRIM21 TRIM21 DDRGK1 DDRGK1 NLK NLK TMEM183A TMEM183A IGF1 IGF1 SAV1 SAV1 CAMLG CAMLG COG7 COG7 PLK1 PLK1 CALR CALR RAD23A RAD23A STK3 STK3 EP300 EP300 AHSP AHSP PYCARD PYCARD AFM AFM CSN3 CSN3 TSPAN1 TSPAN1 CTNND1 CTNND1 CDC73 CDC73 GGA3 GGA3 ISOC1 ISOC1 CLUL1 CLUL1 CCNH CCNH KRAS KRAS LRRK2 LRRK2 HYPK HYPK SERF2 SERF2 TRIM61 TRIM61 LOC102747519 LOC102747519 PEX2 PEX2 LOC102729474 LOC102729474 FBXW7 FBXW7 TAF9B TAF9B CCT2 CCT2 DVL1 DVL1 GIPC2 GIPC2 USP33 USP33 PTEN PTEN PRKRA PRKRA PFN2 PFN2 CREB1 CREB1 SENP2 SENP2 DIEXF DIEXF LOC102729936 LOC102729936 SRC SRC LOC102728923 LOC102728923 PIM1 PIM1 PDCL3 PDCL3 BAG1 BAG1 SEPT8 SEPT8 DPM3 DPM3 EFNA1 EFNA1 SLC51B SLC51B PPIB PPIB MARCH7 MARCH7 STK4 STK4 MCM8 MCM8 RASSF2 RASSF2 PDCD10 PDCD10 COG3 COG3 RNF5 RNF5 BAG2 BAG2 GSN GSN WRB WRB LOC102726900 LOC102726900 USP3 USP3 PEX6 PEX6 CCT3 CCT3 LOC102749952 LOC102749952 FBXO4 FBXO4 SYVN1 SYVN1 LOC102748459 LOC102748459 ATP1B3 ATP1B3 PHB2 PHB2 NAA15 NAA15 HPS4 HPS4 DVL3 DVL3 MUL1 MUL1 GIPC1 GIPC1 PINK1 PINK1 PIM2 PIM2 BAG6 BAG6 KAT2A KAT2A GIPC3 GIPC3 SIRT6 SIRT6 TAF9 TAF9 SERF1A SERF1A ATP1B2 ATP1B2 TP53 TP53 TMEM88 TMEM88 TADA3 TADA3 CRYAB CRYAB TBX3 TBX3 FLNA FLNA USP2 USP2 MDM2 MDM2 LOC102740002 LOC102740002 TRIM24 TRIM24 PIN1 PIN1 DSG1 DSG1 HDAC8 HDAC8 CMTM6 CMTM6 FLOT2 FLOT2 USP8 USP8 A1CF A1CF NAA16 NAA16 CCAR2 CCAR2 CD74 CD74 WDR81 WDR81 BAG4 BAG4 CHEK2 CHEK2 FAM154A FAM154A TELO2 TELO2 RNF139 RNF139 PEX19 PEX19 MAPK1 MAPK1 EPHA4 EPHA4 RNF128 RNF128 MSX1 MSX1 LOC102744979 LOC102744979 DACT1 DACT1 DPM2 DPM2 PRNP PRNP STXBP4 STXBP4 CASP3 CASP3 MORC3 MORC3 LSS LSS USP13 USP13 CTSH CTSH LOC102740821 LOC102740821 GOLGA7 GOLGA7 NR1D1 NR1D1 LOC102749901 LOC102749901 LOC102729387 LOC102729387 CREBBP CREBBP PARK7 PARK7 LOC102736516 LOC102736516 TBRG1 TBRG1 USP47 USP47 HSP90AB1 HSP90AB1 TTI2 TTI2 OTUD3 OTUD3 DERL1 DERL1 BAG5 BAG5 LOC102726367 LOC102726367 DDI2 DDI2 CRYAA CRYAA KDM8 KDM8 CDKN2AIP CDKN2AIP ISOC2 ISOC2 WFS1 WFS1 LOC102730835 LOC102730835 BMP2 BMP2 LOC102730931 LOC102730931 HDAC3 HDAC3 FBXW9 FBXW9 TREX1 TREX1 VPS35 VPS35 LOC102738369 LOC102738369 LOC102737664 LOC102737664 CTSA CTSA LMNA LMNA LOC102739786 LOC102739786 LOC102739181 LOC102739181 WNT10B WNT10B LOC102741471 LOC102741471 LOC102751021 LOC102751021 LOC102731358 LOC102731358 LOC102747171 LOC102747171 LOC102743697 LOC102743697 TADA2A TADA2A APOA2 APOA2 APOA1 APOA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX17Transcription factor SOX-17-like. (406 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
DDRGK1DDRGK domain-containing protein 1. (315 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
TMEM183ATransmembrane protein 183A. (253 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
SAV1Protein salvador homolog 1. (384 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
COG7Conserved oligomeric Golgi complex subunit 7. (731 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
CALRCalreticulin. (417 aa)
RAD23AUV excision repair protein RAD23 homolog A isoform X1. (363 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
EP300Histone acetyltransferase p300. (2425 aa)
AHSPAlpha-hemoglobin-stabilizing protein. (92 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
AFMAfamin. (604 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (182 aa)
TSPAN1Tetraspanin. (241 aa)
CTNND1Catenin delta-1 isoform X2. (1022 aa)
CDC73Parafibromin. (418 aa)
GGA3ADP-ribosylation factor-binding protein GGA3 isoform X1. (729 aa)
ISOC1Isochorismatase domain-containing protein 1. (296 aa)
CLUL1Clusterin-like protein 1. (288 aa)
CCNHcyclin-H-like; Belongs to the cyclin family. (344 aa)
KRASGTPase KRas isoform X2. (188 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
HYPKHuntingtin-interacting protein K. (121 aa)
SERF2Small EDRK-rich factor 2 isoform X1. (170 aa)
TRIM61Tripartite motif-containing protein 60. (470 aa)
LOC102747519Tripartite motif-containing protein 60-like. (474 aa)
PEX2Peroxisome biogenesis factor 2 isoform X1. (305 aa)
LOC102729474Putative tripartite motif-containing protein 75-like. (469 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (250 aa)
CCT2T-complex protein 1 subunit beta. (543 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
GIPC2PDZ domain-containing protein GIPC2. (312 aa)
USP33Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (904 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKRAInterferon-inducible double-stranded RNA-dependent protein kinase activator A. (313 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SENP2Sentrin-specific protease 2. (590 aa)
DIEXFDigestive organ expansion factor homolog. (757 aa)
LOC102729936T-complex protein 1 subunit alpha-like. (556 aa)
SRCTyrosine-protein kinase. (536 aa)
LOC102728923Activating transcription factor 7-interacting protein 1-like. (337 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
PDCL3Phosducin-like protein 3. (239 aa)
BAG1BAG family molecular chaperone regulator 1. (395 aa)
SEPT8Septin-8 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (382 aa)
DPM3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
SLC51BOrganic solute transporter subunit beta. (128 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7. (695 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MCM8DNA helicase MCM8 isoform X1; Belongs to the MCM family. (833 aa)
RASSF2Ras association domain-containing protein 2. (271 aa)
PDCD10Programmed cell death protein 10 isoform X1. (212 aa)
COG3Conserved oligomeric Golgi complex subunit 3. (886 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (180 aa)
BAG2BAG family molecular chaperone regulator 2. (211 aa)
GSNGelsolin. (189 aa)
WRBTail-anchored protein insertion receptor WRB. (174 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
USP3Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (520 aa)
PEX6Peroxisome assembly factor 2 isoform X1. (980 aa)
CCT3T-complex protein 1 subunit gamma. (545 aa)
LOC102749952Lysosomal protein NCU-G1 isoform X1. (406 aa)
FBXO4F-box only protein 4. (387 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin. (612 aa)
LOC102748459Prorelaxin-like. (186 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PHB2Prohibitin. (299 aa)
NAA15N-alpha-acetyltransferase 15, NatA auxiliary subunit. (866 aa)
HPS4Hermansky-Pudlak syndrome 4 protein. (715 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
GIPC1PDZ domain-containing protein GIPC1. (333 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (488 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1163 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
GIPC3PDZ domain-containing protein GIPC3. (312 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
TAF9Transcription initiation factor TFIID subunit 9-like isoform X1. (265 aa)
SERF1ASmall EDRK-rich factor 1. (62 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TMEM88Transmembrane protein 88. (159 aa)
TADA3Transcriptional adapter 3 isoform X1. (432 aa)
CRYABAlpha-crystallin B chain isoform X1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
TBX3T-box transcription factor TBX3. (675 aa)
FLNAfilamin-A-like. (1685 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
LOC102740002Glyceraldehyde-3-phosphate dehydrogenase. (290 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1050 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
DSG1Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1052 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (415 aa)
CMTM6CKLF-like MARVEL transmembrane domain-containing protein 6 isoform X2. (183 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)
A1CFAPOBEC1 complementation factor. (592 aa)
NAA16N-alpha-acetyltransferase 16, NatA auxiliary subunit. (832 aa)
CCAR2Cell cycle and apoptosis regulator protein 2. (918 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
WDR81WD repeat-containing protein 81 isoform X1. (1943 aa)
BAG4BAG family molecular chaperone regulator 4. (421 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
FAM154AProtein FAM154A. (410 aa)
TELO2Telomere length regulation protein TEL2 homolog. (822 aa)
RNF139E3 ubiquitin-protein ligase RNF139. (664 aa)
PEX19Peroxisomal biogenesis factor 19 isoform X1. (299 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
RNF128E3 ubiquitin-protein ligase RNF128 isoform X1. (431 aa)
MSX1Homeobox protein MSX-1. (303 aa)
LOC102744979DNL-type zinc finger protein-like. (102 aa)
DACT1Dapper homolog 1. (523 aa)
DPM2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (84 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
MORC3MORC family CW-type zinc finger protein 3. (900 aa)
LSSLanosterol synthase; Belongs to the terpene cyclase/mutase family. (558 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
LOC102740821Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
GOLGA7Golgin subfamily A member 7 isoform X1. (137 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
LOC102749901Gamma-interferon-inducible-lysosomal thiol reductase-like. (252 aa)
LOC102729387F-box only protein 7-like. (300 aa)
CREBBPCREB-binding protein-like. (1411 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47; Belongs to the peptidase C19 family. (1287 aa)
HSP90AB1Heat shock protein HSP 90-beta. (464 aa)
TTI2TELO2-interacting protein 2. (508 aa)
OTUD3OTU domain-containing protein 3. (395 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
BAG5BAG family molecular chaperone regulator 5. (448 aa)
LOC102726367Heat shock protein HSP 90-alpha-like. (262 aa)
DDI2Regulatory solute carrier protein family 1 member 1-like isoform X2. (399 aa)
CRYAAAlpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
KDM8Lysine-specific demethylase 8. (414 aa)
CDKN2AIPCDKN2A-interacting protein. (582 aa)
ISOC2Isochorismatase domain-containing protein 2, mitochondrial isoform X1. (204 aa)
WFS1Wolframin-like. (882 aa)
LOC102730835T-complex protein 1 subunit beta-like. (535 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
LOC102730931Prolyl 3-hydroxylase 1-like. (349 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
VPS35Vacuolar protein sorting-associated protein 35. (509 aa)
LOC102738369Merlin-like. (110 aa)
LOC102737664Gelsolin-like. (513 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (495 aa)
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
LOC102739786Huntingtin-interacting protein 1-like. (415 aa)
LOC102739181Ubiquitin carboxyl-terminal hydrolase 4-like; Belongs to the peptidase C19 family. (611 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102741471Parafibromin-like. (141 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102731358Lanosterol synthase-like. (109 aa)
LOC102747171Hsp90 co-chaperone Cdc37-like. (341 aa)
LOC102743697Probable ubiquitin carboxyl-terminal hydrolase FAF-X-like. (164 aa)
TADA2ALOW QUALITY PROTEIN: transcriptional adaptor 2A. (306 aa)
APOA2Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (100 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (266 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (30%) [HD]