STRINGSTRING
LOC102748411 LOC102748411 ALOX5 ALOX5 LOC102738237 LOC102738237 GRIN3A GRIN3A SEMA6D SEMA6D LOC102726335 LOC102726335 LRFN5 LRFN5 SEMA3C SEMA3C SEMA3A SEMA3A HGF HGF SEMA3D SEMA3D GATA3 GATA3 PRKG1 PRKG1 CST7 CST7 ANGPT2 ANGPT2 THBD THBD STAT2 STAT2 SUSD4 SUSD4 USP15 USP15 RB1 RB1 SEMA7A SEMA7A MKRN2 MKRN2 LOC102736999 LOC102736999 FEM1A FEM1A NLRX1 NLRX1 KLK8 KLK8 SIGLEC10 SIGLEC10 RNF26 RNF26 NDFIP1 NDFIP1 TRIB1 TRIB1 GPATCH3 GPATCH3 C5AR2 C5AR2 SIRT2 SIRT2 PLXNA3 PLXNA3 ATG5 ATG5 GHRL GHRL CARTPT CARTPT GPS2 GPS2 CACTIN CACTIN ARG2 ARG2 DHX58 DHX58 TNF TNF LOC102742895 LOC102742895 AIF1 AIF1 IL2 IL2 MUL1 MUL1 ADTRP ADTRP TNFRSF1A TNFRSF1A LPCAT3 LPCAT3 SEMA3F SEMA3F NLRP12 NLRP12 PPARD PPARD RYK RYK ATG12 ATG12 LOC102730452 LOC102730452 TYRO3 TYRO3 C5 C5 CD9 CD9 IRG1 IRG1 LOC102735085 LOC102735085 IL22RA2 IL22RA2 TNFAIP3 TNFAIP3 ADAR ADAR ASH1L ASH1L TREM2 TREM2 LOC102734924 LOC102734924 CD109 CD109 LOC102744509 LOC102744509 LOC102737563 LOC102737563 LOC102726994 LOC102726994 SEMA4A SEMA4A LOC102736765 LOC102736765 LOC102739972 LOC102739972 LOC102730741 LOC102730741 YTHDF3 YTHDF3 C1QTNF6 C1QTNF6 SEMA5B SEMA5B LOC102744819 LOC102744819 SEMA3B SEMA3B GPR31 GPR31 VPS35 VPS35 TREX1 TREX1 LYAR LYAR ADORA2A ADORA2A INS INS FGF2 FGF2 LOC102730527 LOC102730527 LOC102730318 LOC102730318 PPARA PPARA LOC102740157 LOC102740157 CLDN19 CLDN19 GPER1 GPER1 BBS2 BBS2 LOC102747249 LOC102747249 DRD3 DRD3 SEMA6B SEMA6B UBASH3B UBASH3B LOC102726250 LOC102726250 LEP LEP AJAP1 AJAP1 SOCS5 SOCS5 PDGFRA PDGFRA LOC102748609 LOC102748609 ADAMTS18 ADAMTS18 OTOP1 OTOP1 CPB2 CPB2 NOV NOV LOC102749512 LOC102749512 PROC PROC PDGFB PDGFB RIN3 RIN3 SEMA4G SEMA4G RTN4R RTN4R SHARPIN SHARPIN NR1D1 NR1D1 C1QTNF1 C1QTNF1 EPPK1 EPPK1 SEMA6A SEMA6A LOC102742614 LOC102742614 NR1D2 NR1D2 CNOT7 CNOT7 FOXF1 FOXF1 LDLR LDLR NENF NENF SEMA5A SEMA5A PTPN2 PTPN2 WNT3 WNT3 FNDC4 FNDC4 UCN UCN CORO1B CORO1B EPHA4 EPHA4 WNT3A WNT3A ZFP36 ZFP36 CXCL13 CXCL13 ALOX12 ALOX12 TARBP2 TARBP2 PLA2G10 PLA2G10 IL13 IL13 RIOK3 RIOK3 LOC102731157 LOC102731157 TNFAIP6 TNFAIP6 NMI NMI LOC102744421 LOC102744421 SOCS3 SOCS3 SERPING1 SERPING1 KNG1 KNG1 SEMA6C SEMA6C FAM19A3 FAM19A3 TNFAIP8L2 TNFAIP8L2 IL10 IL10 SEMA4C SEMA4C SERPINE1 SERPINE1 SAMHD1 SAMHD1 GHSR GHSR GRID2 GRID2 PTGER4 PTGER4 FAM105B FAM105B VSIG4 VSIG4 AOAH AOAH PTEN PTEN SPINK5 SPINK5 ISG15 ISG15 FAM132A FAM132A DVL1 DVL1 TTLL12 TTLL12 TRIM21 TRIM21 KLRK1 KLRK1 CLEC12B CLEC12B FGL2 FGL2 GPR18 GPR18 SEMA3G SEMA3G IGF1 IGF1 MYOZ1 MYOZ1 HAVCR2 HAVCR2 GREM1 GREM1 NR1H3 NR1H3 RABGEF1 RABGEF1 APOH APOH STAP1 STAP1 NT5E NT5E LOC102741936 LOC102741936 NLRC3 NLRC3 FOXP3 FOXP3 NOD2 NOD2 FFAR4 FFAR4 THBS1 THBS1 KLKB1 KLKB1 NLRP6 NLRP6 MFHAS1 MFHAS1 CRK CRK VIMP VIMP RTN4RL1 RTN4RL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102748411UNC119-binding protein C5orf30 homolog isoform X1. (207 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
LOC102738237SEC14-like protein 1-like. (239 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A. (1115 aa)
SEMA6Dsemaphorin-6D-like isoform X3; Belongs to the semaphorin family. (1017 aa)
LOC102726335Glutamate receptor ionotropic, delta-2-like isoform X1. (787 aa)
LRFN5Leucine-rich repeat and fibronectin type-III domain-containing protein 5-like. (719 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (696 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
SEMA3DLOW QUALITY PROTEIN: semaphorin-3D; Belongs to the semaphorin family. (781 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
PRKG1cGMP-dependent protein kinase 1. (193 aa)
CST7cystatin-F. (153 aa)
ANGPT2Angiopoietin-2 isoform X1. (495 aa)
THBDThrombomodulin. (577 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
SUSD4Sushi domain-containing protein 4. (295 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
RB1Retinoblastoma-associated protein. (846 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2 isoform X1. (416 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
FEM1AProtein fem-1 homolog A isoform X1. (664 aa)
NLRX1NLR family member X1. (975 aa)
KLK8Kallikrein-8; Belongs to the peptidase S1 family. (273 aa)
SIGLEC10Sialic acid-binding Ig-like lectin 10. (692 aa)
RNF26RING finger protein 26. (434 aa)
NDFIP1NEDD4 family-interacting protein 1 isoform X1. (221 aa)
TRIB1Tribbles homolog 1. (292 aa)
GPATCH3G patch domain-containing protein 3. (519 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2. (337 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PLXNA3plexin-A3. (1452 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
GHRLAppetite-regulating hormone isoform X1. (117 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (116 aa)
GPS2G protein pathway suppressor 2 isoform X1. (327 aa)
CACTINCactin. (749 aa)
ARG2Arginase. (354 aa)
DHX58Probable ATP-dependent RNA helicase DHX58 isoform X1. (678 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102742895NF-kappa-B inhibitor-like protein 1-like. (255 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
ADTRPAndrogen-dependent TFPI-regulating protein. (260 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (786 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
RYKTyrosine-protein kinase RYK. (475 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
LOC102730452semaphorin-4A-like; Belongs to the semaphorin family. (436 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (845 aa)
C5Complement C5. (1391 aa)
CD9Tetraspanin. (226 aa)
IRG1Cis-aconitate decarboxylase. (481 aa)
LOC102735085semaphorin-4F-like; Belongs to the semaphorin family. (449 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (231 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1145 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L. (2965 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
LOC102734924Spexin. (115 aa)
CD109CD109 antigen. (1322 aa)
LOC102744509Autophagy protein 5-like. (78 aa)
LOC102737563Complement C5-like. (186 aa)
LOC102726994Uracil nucleotide/cysteinyl leukotriene receptor-like; Belongs to the G-protein coupled receptor 1 family. (339 aa)
SEMA4Asemaphorin-4A-like. (350 aa)
LOC102736765Interleukin-1 receptor-associated kinase 3-like. (125 aa)
LOC102739972Reticulon-4 receptor-like 1-like. (435 aa)
LOC102730741Natural killer cells antigen CD94-like. (162 aa)
YTHDF3YTH domain family protein 3-like isoform X1. (531 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (265 aa)
SEMA5Bsemaphorin-5B-like. (989 aa)
LOC102744819Mevalonate kinase-like. (230 aa)
SEMA3Bsemaphorin-3B. (166 aa)
GPR3112-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)
VPS35Vacuolar protein sorting-associated protein 35. (509 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
LYARCell growth-regulating nucleolar protein-like. (394 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102730527Breakpoint cluster region protein-like. (172 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
LOC102740157Cadherin-5-like; Cadherins are calcium-dependent cell adhesion proteins. (464 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
BBS2Bardet-Biedl syndrome 2 protein-like. (603 aa)
LOC102747249Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (271 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (673 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B. (592 aa)
LOC102726250Ubiquitin fusion degradation protein 1 homolog. (117 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
AJAP1Adherens junction-associated protein 1-like. (401 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
LOC102748609Sodium-dependent dopamine transporter-like. (364 aa)
ADAMTS18A disintegrin and metalloproteinase with thrombospondin motifs 18. (1021 aa)
OTOP1Otopetrin-1. (418 aa)
CPB2Carboxypeptidase B2. (423 aa)
NOVProtein NOV homolog. (353 aa)
LOC102749512Protein NLRC3-like. (756 aa)
PROCVitamin K-dependent protein C; Belongs to the peptidase S1 family. (203 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RIN3Ras and Rab interactor 3. (588 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (840 aa)
RTN4RReticulon-4 receptor. (528 aa)
SHARPINSharpin isoform X1. (283 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (279 aa)
EPPK1Epiplakin. (1715 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
LOC102742614Peripheral plasma membrane protein CASK-like. (818 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (576 aa)
CNOT7CCR4-NOT transcription complex subunit 7 isoform X1. (285 aa)
FOXF1Forkhead box protein F1. (427 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (146 aa)
SEMA5Asemaphorin-5A-like. (1034 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FNDC4Fibronectin type III domain-containing protein 4 isoform X1. (226 aa)
UCNUrocortin. (126 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (489 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ZFP36Tristetraprolin. (325 aa)
CXCL13c-X-C motif chemokine 13. (110 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
PLA2G10Phospholipase A(2). (163 aa)
IL13Interleukin-13. (133 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
LOC102731157ARF GTPase-activating protein GIT1-like. (191 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
NMIN-myc-interactor. (314 aa)
LOC102744421Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (476 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (963 aa)
FAM19A3Protein FAM19A3. (133 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2. (184 aa)
IL10Interleukin-10. (178 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
SAMHD1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (627 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GRID2Glutamate receptor ionotropic, delta-2. (211 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
FAM105BUbiquitin thioesterase otulin. (298 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4 isoform X1. (399 aa)
AOAHLOW QUALITY PROTEIN: acyloxyacyl hydrolase. (533 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SPINK5Serine protease inhibitor Kazal-type 5-like. (1068 aa)
ISG15Ubiquitin-like protein ISG15. (169 aa)
FAM132AProtein FAM132A. (310 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
TTLL12Tubulin--tyrosine ligase-like protein 12. (645 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
KLRK1NKG2-D type II integral membrane protein. (216 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
FGL2Fibroleukin. (440 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (770 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
MYOZ1Myozenin-1 isoform X2. (221 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
GREM1Gremlin. (184 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (456 aa)
RABGEF1Rab5 GDP/GTP exchange factor. (491 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
STAP1Signal-transducing adaptor protein 1. (332 aa)
NT5E5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (574 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
NLRC3Protein NLRC3. (330 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
FFAR4Free fatty acid receptor 4. (254 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
KLKB1Plasma kallikrein; Belongs to the peptidase S1 family. (634 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (893 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1-like. (1052 aa)
CRKAdapter molecule crk. (92 aa)
VIMPSelenoprotein S. (188 aa)
RTN4RL1Reticulon-4 receptor-like 1. (477 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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