STRINGSTRING
LOC102730129 LOC102730129 LOC102740025 LOC102740025 HGF HGF DKK2 DKK2 SFRP2 SFRP2 NCK1 NCK1 RET RET STOX1 STOX1 CAV1 CAV1 DDIT4 DDIT4 AXIN1 AXIN1 PTEN PTEN DOCK7 DOCK7 LOC102747757 LOC102747757 LOC102750324 LOC102750324 LOC102747471 LOC102747471 IFNB1 IFNB1 PFN2 PFN2 PRKAA1 PRKAA1 INPP5J INPP5J LOC102731771 LOC102731771 SH2D3A SH2D3A STK4 STK4 GADD45A GADD45A RASSF2 RASSF2 PTGER2 PTGER2 PDCD10 PDCD10 LATS1 LATS1 BDKRB2 BDKRB2 NTF3 NTF3 RAMP3 RAMP3 LOC102726900 LOC102726900 MTCP1 MTCP1 IFNK IFNK BAK1 BAK1 PINK1 PINK1 TNF TNF LOC102728326 LOC102728326 IFNE IFNE PAQR3 PAQR3 DMTN DMTN MAPKAP1 MAPKAP1 IFNA14 IFNA14 PIK3CA PIK3CA LOC102737831 LOC102737831 GNB2L1 GNB2L1 PARK7 PARK7 GGNBP2 GGNBP2 TGFB1 TGFB1 NCK2 NCK2 LOC102730920 LOC102730920 IL11 IL11 LOC102740057 LOC102740057 TCL1B TCL1B GSK3A GSK3A TXN TXN UCN UCN PPM1F PPM1F RICTOR RICTOR LOC102729555 LOC102729555 BAG4 BAG4 INPP5K INPP5K RAF1 RAF1 IFNG IFNG PAK1 PAK1 LOC102741496 LOC102741496 NTRK2 NTRK2 NGF NGF SMYD3 SMYD3 GAS6 GAS6 NTF4 NTF4 OPRD1 OPRD1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
DKK2Dickkopf-related protein 2. (259 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
NCK1Cytoplasmic protein. (377 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
STOX1Storkhead-box protein 1. (881 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
AXIN1Axin-1 isoform X1. (867 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2129 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
IFNB1Interferon beta. (182 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
INPP5JPhosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1. (1004 aa)
LOC102731771Telomeric repeat-binding factor 2-interacting protein 1-like. (122 aa)
SH2D3ASH2 domain-containing protein 3A. (577 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
RASSF2Ras association domain-containing protein 2. (271 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PDCD10Programmed cell death protein 10 isoform X1. (212 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
RAMP3Receptor activity-modifying protein 3. (116 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
MTCP1Protein p13 MTCP-1. (107 aa)
IFNKInterferon kappa. (208 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (488 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102728326Breast cancer anti-estrogen resistance protein 3-like. (176 aa)
IFNEInterferon epsilon. (208 aa)
PAQR3Progestin and adipoQ receptor family member 3 isoform X2. (311 aa)
DMTNDematin isoform X1. (405 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (122 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
GGNBP2Gametogenetin-binding protein 2 isoform X1. (740 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
NCK2Cytoplasmic protein. (380 aa)
LOC102730920Periodic tryptophan protein 1 homolog. (166 aa)
IL11Interleukin-11. (120 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
TCL1BT-cell leukemia/lymphoma protein 1B. (127 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
UCNUrocortin. (126 aa)
PPM1FProtein phosphatase 1F. (287 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
LOC102729555oncostatin-M-like. (214 aa)
BAG4BAG family molecular chaperone regulator 4. (421 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LOC102741496BDNF/NT-3 growth factors receptor-like. (97 aa)
NTRK2BDNF/NT-3 growth factors receptor-like. (420 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
SMYD3Histone-lysine N-methyltransferase SMYD3. (190 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (211 aa)
OPRD1Delta-type opioid receptor-like; Belongs to the G-protein coupled receptor 1 family. (288 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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