STRINGSTRING
MDM2 MDM2 GCKR GCKR LOC102751021 LOC102751021 CDK5 CDK5 LOC102727190 LOC102727190 LOC102745331 LOC102745331 LMNA LMNA LOC102735151 LOC102735151 LOC102726875 LOC102726875 CDKN1A CDKN1A IPO13 IPO13 CRY2 CRY2 TOR1B TOR1B STAT3 STAT3 HNRNPU HNRNPU TNPO2 TNPO2 NF1 NF1 CSE1L CSE1L RRS1 RRS1 FAM53B FAM53B LOC102740547 LOC102740547 LOC102736637 LOC102736637 TOR1A TOR1A NUP188 NUP188 NUP214 NUP214 LOC102750113 LOC102750113 ARL2BP ARL2BP BCL3 BCL3 NUP88 NUP88 SHISA4 SHISA4 TBRG1 TBRG1 E2F3 E2F3 LOC102736516 LOC102736516 PTTG1IP PTTG1IP PARK7 PARK7 MED1 MED1 LOC102735609 LOC102735609 AKIRIN2 AKIRIN2 TNPO3 TNPO3 MORC3 MORC3 NUP93 NUP93 LOC102727345 LOC102727345 KPNB1 KPNB1 SNUPN SNUPN NUP62 NUP62 CIZ1 CIZ1 TXN TXN NUP54 NUP54 MSX1 MSX1 LOC102750756 LOC102750756 PAF1 PAF1 KPNA1 KPNA1 NUP50 NUP50 NXT1 NXT1 XPA XPA BMP7 BMP7 NOL8 NOL8 RANBP6 RANBP6 ATF2 ATF2 TAF3 TAF3 PML PML RAN RAN NUP133 NUP133 NUP107 NUP107 LOC102744037 LOC102744037 GPN2 GPN2 IPO4 IPO4 WRAP53 WRAP53 CTDNEP1 CTDNEP1 TP53 TP53 LOC102745161 LOC102745161 ASUN ASUN PHB2 PHB2 OSBPL8 OSBPL8 RPL11 RPL11 POLA2 POLA2 SUN1 SUN1 FAM53C FAM53C NXT2 NXT2 KPNA3 KPNA3 ARL2 ARL2 GPN3 GPN3 SIX2 SIX2 TOR1AIP2 TOR1AIP2 LOC102729442 LOC102729442 LMNB1 LMNB1 POM121L2 POM121L2 TRAF3IP2 TRAF3IP2 RPF2 RPF2 STK4 STK4 LOC102731875 LOC102731875 KPNA5 KPNA5 IPO5 IPO5 HHEX HHEX ELAVL1 ELAVL1 DIEXF DIEXF EIF4ENIF1 EIF4ENIF1 XPO1 XPO1 LOC102743906 LOC102743906 DVL1 DVL1 RRP7A RRP7A NFKBIA NFKBIA PYGO1 PYGO1 ABRA ABRA TMCO6 TMCO6 TPR TPR PLK1 PLK1 CNEP1R1 CNEP1R1 NUP155 NUP155 HEATR3 HEATR3 IPO8 IPO8 STK3 STK3 LOC102730522 LOC102730522 SIX4 SIX4 TXNIP TXNIP RANGAP1 RANGAP1 SIX1 SIX1 PPP3R1 PPP3R1 NR5A2 NR5A2 LOC102738950 LOC102738950 KPNA2 KPNA2 RAP1GDS1 RAP1GDS1 RANBP2 RANBP2 IPO7 IPO7 CLDN18 CLDN18 FGF9 FGF9 LRRK2 LRRK2 PLRG1 PLRG1 NUP35 NUP35
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
GCKRLOW QUALITY PROTEIN: glucokinase (Hexokinase 4) regulator. (482 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
LOC102745331Transcription initiation factor TFIID subunit 8-like. (269 aa)
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
LOC102735151Bone morphogenetic protein 7-like. (139 aa)
LOC102726875POM121-like protein 2-like. (247 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
IPO13Importin-13. (963 aa)
CRY2Cryptochrome-2. (527 aa)
TOR1BTorsin. (341 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
TNPO2Transportin-2. (897 aa)
NF1Neurofibromin-like. (1269 aa)
CSE1LExportin-2 isoform X1. (971 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (371 aa)
FAM53BProtein FAM53B. (426 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102736637Nuclear pore complex protein Nup93-like. (163 aa)
TOR1Atorsin-1A. (272 aa)
NUP188Nucleoporin NUP188 homolog. (1750 aa)
NUP214Nuclear pore complex protein Nup214-like. (1002 aa)
LOC102750113Importin subunit alpha; Functions in nuclear protein import. (523 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (163 aa)
BCL3B-cell lymphoma 3 protein. (407 aa)
NUP88Nuclear pore complex protein Nup88. (738 aa)
SHISA4Protein shisa-4. (197 aa)
TBRG1Transforming growth factor beta regulator 1. (411 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
PTTG1IPPituitary tumor-transforming gene 1 protein-interacting protein. (199 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
LOC102735609Nuclear envelope pore membrane protein POM 121-like. (409 aa)
AKIRIN2Akirin-2. (115 aa)
TNPO3Transportin-3. (751 aa)
MORC3MORC family CW-type zinc finger protein 3. (900 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (662 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
KPNB1Importin subunit beta-1 isoform X3. (876 aa)
SNUPNSnurportin-1 isoform X1. (368 aa)
NUP62Nuclear pore glycoprotein p62. (525 aa)
CIZ1Cip1-interacting zinc finger protein. (834 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
NUP54Nucleoporin p54 isoform X1. (562 aa)
MSX1Homeobox protein MSX-1. (303 aa)
LOC10275075614-3-3 protein epsilon-like; Belongs to the 14-3-3 family. (233 aa)
PAF1RNA polymerase II-associated factor 1 homolog isoform X2. (528 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (538 aa)
NUP50Nuclear pore complex protein Nup50. (461 aa)
NXT1NTF2-related export protein 1. (140 aa)
XPADNA repair protein complementing XP-A cells. (273 aa)
BMP7Bone morphogenetic protein 7-like. (312 aa)
NOL8Nucleolar protein 8. (1126 aa)
RANBP6Ran-binding protein 6 isoform X1. (1105 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
TAF3Transcription initiation factor TFIID subunit 3. (774 aa)
PMLProtein PML. (880 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
NUP133Nuclear pore complex protein Nup133. (707 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
LOC102744037Importin subunit alpha-3-like. (241 aa)
GPN2GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (310 aa)
IPO4Importin-4. (1080 aa)
WRAP53Telomerase Cajal body protein 1. (532 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
ASUNProtein asunder homolog isoform X3. (605 aa)
PHB2Prohibitin. (299 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
RPL1160S ribosomal protein L11 isoform X2; Belongs to the universal ribosomal protein uL5 family. (178 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (595 aa)
SUN1SUN domain-containing protein 1. (471 aa)
FAM53CProtein FAM53C isoform X1. (392 aa)
NXT2NTF2-related export protein 2 isoform X1. (142 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (497 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (284 aa)
SIX2Homeobox protein SIX2. (294 aa)
TOR1AIP2torsin-1A-interacting protein 2-like. (457 aa)
LOC102729442Protein Hikeshi. (197 aa)
LMNB1lamin-B1; Belongs to the intermediate filament family. (547 aa)
POM121L2POM121-like protein 2. (1025 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (563 aa)
RPF2Ribosome production factor 2 homolog. (306 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
LOC102731875Nuclear pore complex protein Nup214-like. (223 aa)
KPNA5Importin subunit alpha; Functions in nuclear protein import. (539 aa)
IPO5Importin-5 isoform X1. (1097 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (270 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
DIEXFDigestive organ expansion factor homolog. (757 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E transporter isoform X1. (987 aa)
XPO1Exportin-1. (384 aa)
LOC102743906Nuclear transport factor 2-like. (127 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
RRP7ARibosomal RNA-processing protein 7 homolog A. (280 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
PYGO1Pygopus homolog 1. (419 aa)
ABRAActin-binding Rho-activating protein. (380 aa)
TMCO6Transmembrane and coiled-coil domain-containing protein 6. (493 aa)
TPRNucleoprotein TPR-like isoform X1. (2439 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
CNEP1R1Nuclear envelope phosphatase-regulatory subunit 1. (125 aa)
NUP155Nuclear pore complex protein Nup155 isoform X1. (1391 aa)
HEATR3HEAT repeat-containing protein 3. (680 aa)
IPO8Importin-8 isoform X1. (1036 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
LOC102730522POM121-like protein 12-like. (267 aa)
SIX4Homeobox protein SIX4. (778 aa)
TXNIPThioredoxin-interacting protein-like. (391 aa)
RANGAP1Ran GTPase-activating protein 1. (549 aa)
SIX1Homeobox protein SIX1. (284 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2-like isoform X1. (541 aa)
LOC102738950GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (215 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1 isoform X1. (607 aa)
RANBP2E3 SUMO-protein ligase RanBP2. (3100 aa)
IPO7Importin-7 isoform X1. (1038 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
PLRG1Pleiotropic regulator 1 isoform X1. (515 aa)
NUP35Nucleoporin NUP53. (237 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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