(17 nodes) Negative regulation of Rho protein signal transduction network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	ARHGAP42	Rho GTPase-activating protein 42. (874 aa)
	TNFAIP1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2. (316 aa)
	FAM65C	Protein FAM65C. (944 aa)
	LOC102742081	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-like. (186 aa)
	MYOC	Myocilin. (490 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	CCDC125	Coiled-coil domain-containing protein 125. (513 aa)
	LOC102733393	Protein FAM65B-like. (563 aa)
	KCTD10	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3. (317 aa)
	SCAI	Protein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. (606 aa)
	FLCN	Folliculin. (579 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	LOC102729692	Ras-interacting protein 1-like. (208 aa)
	ARAP3	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3. (1542 aa)
	LOC102728905	KN motif and ankyrin repeat domain-containing protein 1-like. (167 aa)
	LOC102725974	KN motif and ankyrin repeat domain-containing protein 1-like. (247 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCTD10	LOC102742081	A0A2U3YEX3	A0A2U3XRE4	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-like.	0.733
KCTD10	TNFAIP1	A0A2U3YEX3	A0A2U3XJL0	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	0.745
LOC102725974	LOC102728905	A0A2U3Z787	A0A2U3Z4X7	KN motif and ankyrin repeat domain-containing protein 1-like.	KN motif and ankyrin repeat domain-containing protein 1-like.	0.900
LOC102728905	LOC102725974	A0A2U3Z4X7	A0A2U3Z787	KN motif and ankyrin repeat domain-containing protein 1-like.	KN motif and ankyrin repeat domain-containing protein 1-like.	0.900
LOC102742081	KCTD10	A0A2U3XRE4	A0A2U3YEX3	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-like.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	0.733
LOC102742081	TNFAIP1	A0A2U3XRE4	A0A2U3XJL0	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-like.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	0.744
TNFAIP1	KCTD10	A0A2U3XJL0	A0A2U3YEX3	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3.	0.745
TNFAIP1	LOC102742081	A0A2U3XJL0	A0A2U3XRE4	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2.	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-like.	0.744