(7 nodes) CD4-positive, alpha-beta T cell proliferation network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD28	T-cell-specific surface glycoprotein CD28. (209 aa)
	NDFIP1	NEDD4 family-interacting protein 1 isoform X1. (221 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	LOC102749335	E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
	CARD11	Caspase recruitment domain-containing protein 11. (1146 aa)
	CBLB	E3 ubiquitin-protein ligase CBL-B-like. (832 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (456 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD11	PRKCQ	A0A2U3XF29	A0A2U3XTI0	Caspase recruitment domain-containing protein 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.972
CBLB	LOC102749335	A0A2U3XA16	A0A2U3XH17	E3 ubiquitin-protein ligase CBL-B-like.	E3 ubiquitin-protein ligase CBL-B-like.	0.939
CD28	FOXP3	A0A2U3YTM8	A0A2U3YH69	T-cell-specific surface glycoprotein CD28.	Forkhead box protein P3 isoform X1.	0.433
CD28	PRKCQ	A0A2U3YTM8	A0A2U3XTI0	T-cell-specific surface glycoprotein CD28.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.936
FOXP3	CD28	A0A2U3YH69	A0A2U3YTM8	Forkhead box protein P3 isoform X1.	T-cell-specific surface glycoprotein CD28.	0.433
LOC102749335	CBLB	A0A2U3XH17	A0A2U3XA16	E3 ubiquitin-protein ligase CBL-B-like.	E3 ubiquitin-protein ligase CBL-B-like.	0.939
PRKCQ	CARD11	A0A2U3XTI0	A0A2U3XF29	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Caspase recruitment domain-containing protein 11.	0.972
PRKCQ	CD28	A0A2U3XTI0	A0A2U3YTM8	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	T-cell-specific surface glycoprotein CD28.	0.936