(5 nodes) alphav-beta3 integrin-IGF-1-IGF1R complex network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (852 aa)
	IGF1R	Insulin-like growth factor 1 receptor-like. (291 aa)
	LOC102749673	Insulin-like growth factor 1 receptor-like. (143 aa)
	LOC102731850	Tyrosine-protein kinase receptor. (757 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IGF1	IGF1R	A0A2U3XIR6	A0A2U3Y3Q9	Insulin-like growth factor I isoform X1.	Insulin-like growth factor 1 receptor-like.	0.484
IGF1	LOC102731850	A0A2U3XIR6	A0A2U3Z205	Insulin-like growth factor I isoform X1.	Tyrosine-protein kinase receptor.	0.484
IGF1	LOC102749673	A0A2U3XIR6	A0A2U3Y821	Insulin-like growth factor I isoform X1.	Insulin-like growth factor 1 receptor-like.	0.484
IGF1R	IGF1	A0A2U3Y3Q9	A0A2U3XIR6	Insulin-like growth factor 1 receptor-like.	Insulin-like growth factor I isoform X1.	0.484
IGF1R	LOC102731850	A0A2U3Y3Q9	A0A2U3Z205	Insulin-like growth factor 1 receptor-like.	Tyrosine-protein kinase receptor.	0.900
IGF1R	LOC102749673	A0A2U3Y3Q9	A0A2U3Y821	Insulin-like growth factor 1 receptor-like.	Insulin-like growth factor 1 receptor-like.	0.899
LOC102731850	IGF1	A0A2U3Z205	A0A2U3XIR6	Tyrosine-protein kinase receptor.	Insulin-like growth factor I isoform X1.	0.484
LOC102731850	IGF1R	A0A2U3Z205	A0A2U3Y3Q9	Tyrosine-protein kinase receptor.	Insulin-like growth factor 1 receptor-like.	0.900
LOC102731850	LOC102749673	A0A2U3Z205	A0A2U3Y821	Tyrosine-protein kinase receptor.	Insulin-like growth factor 1 receptor-like.	0.900
LOC102749673	IGF1	A0A2U3Y821	A0A2U3XIR6	Insulin-like growth factor 1 receptor-like.	Insulin-like growth factor I isoform X1.	0.484
LOC102749673	IGF1R	A0A2U3Y821	A0A2U3Y3Q9	Insulin-like growth factor 1 receptor-like.	Insulin-like growth factor 1 receptor-like.	0.899
LOC102749673	LOC102731850	A0A2U3Y821	A0A2U3Z205	Insulin-like growth factor 1 receptor-like.	Tyrosine-protein kinase receptor.	0.900