(27 nodes) Cellular response to vascular endothelial growth factor stimulus network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

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Your Input:
	VEGFB	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	LOC102737831	Serine/threonine-protein kinase D2-like. (246 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PGF	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
	SEMA6A	semaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	MYO1C	Unconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
	EGR3	Early growth response protein 3 isoform X1. (387 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1 isoform X1. (200 aa)
	LOC102738400	Annexin. (345 aa)
	LOC102732879	Disabled homolog 2-interacting protein-like. (454 aa)
	GAB1	GRB2-associated-binding protein 1 isoform X1. (724 aa)
	SHC1	SHC-transforming protein 1 isoform X2. (583 aa)
	NUS1	nogo-B receptor-like. (293 aa)
	HSPB1	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
	LOC102740025	Protein sprouty homolog 2-like isoform X1. (315 aa)
	MAP2K3	Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	LOC102735329	Vascular endothelial growth factor receptor 1-like. (351 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	LOC102743045	Disabled homolog 2-interacting protein-like. (326 aa)
	LOC102740057	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
	LOC102730108	Neuropilin-1-like. (465 aa)
	RAMP2	Receptor activity-modifying protein 2. (118 aa)
	LOC102731352	Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
	LOC102730129	Uncharacterized protein LOC102730129. (471 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL4	LOC102735329	A0A2U3YFQ8	A0A2U3YU32	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor receptor 1-like.	0.418
DLL4	VEGFC	A0A2U3YFQ8	A0A2U3Y8G6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.624
GAB1	LOC102735329	A0A2U3XU49	A0A2U3YU32	GRB2-associated-binding protein 1 isoform X1.	Vascular endothelial growth factor receptor 1-like.	0.575
GAB1	PDGFRA	A0A2U3XU49	A0A2U3YV07	GRB2-associated-binding protein 1 isoform X1.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.904
GAB1	PIK3CA	A0A2U3XU49	A0A2U3YQH7	GRB2-associated-binding protein 1 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.907
GAB1	PIK3CD	A0A2U3XU49	A0A2U3YPT2	GRB2-associated-binding protein 1 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.899
GAB1	SHC1	A0A2U3XU49	A0A2U3XTU7	GRB2-associated-binding protein 1 isoform X1.	SHC-transforming protein 1 isoform X2.	0.947
HSPB1	LOC102737831	A0A2U3XR88	A0A2U3YRJ6	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Serine/threonine-protein kinase D2-like.	0.426
LOC102730108	LOC102730129	A0A2U3Z2Y2	A0A2U3Z8I1	Neuropilin-1-like.	Uncharacterized protein LOC102730129.	0.637
LOC102730108	LOC102735329	A0A2U3Z2Y2	A0A2U3YU32	Neuropilin-1-like.	Vascular endothelial growth factor receptor 1-like.	0.883
LOC102730108	LOC102740057	A0A2U3Z2Y2	A0A2U3Z228	Neuropilin-1-like.	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.637
LOC102730108	PDGFRA	A0A2U3Z2Y2	A0A2U3YV07	Neuropilin-1-like.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.718
LOC102730108	PGF	A0A2U3Z2Y2	A0A2U3YQ46	Neuropilin-1-like.	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family.	0.774
LOC102730108	SEMA6A	A0A2U3Z2Y2	A0A2U3YNU9	Neuropilin-1-like.	semaphorin-6A isoform X1; Belongs to the semaphorin family.	0.702
LOC102730108	VEGFB	A0A2U3Z2Y2	A0A2U3YRT5	Neuropilin-1-like.	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.745
LOC102730108	VEGFC	A0A2U3Z2Y2	A0A2U3Y8G6	Neuropilin-1-like.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.541
LOC102730129	LOC102730108	A0A2U3Z8I1	A0A2U3Z2Y2	Uncharacterized protein LOC102730129.	Neuropilin-1-like.	0.637
LOC102730129	LOC102735329	A0A2U3Z8I1	A0A2U3YU32	Uncharacterized protein LOC102730129.	Vascular endothelial growth factor receptor 1-like.	0.961
LOC102730129	LOC102740057	A0A2U3Z8I1	A0A2U3Z228	Uncharacterized protein LOC102730129.	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.899
LOC102730129	PDGFRA	A0A2U3Z8I1	A0A2U3YV07	Uncharacterized protein LOC102730129.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.914