(7 nodes) ERBB2 signaling pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFA	Protransforming growth factor alpha. (160 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3. (1339 aa)
	EREG	Proepiregulin. (292 aa)
	LOC102741253	Amphiregulin-like. (253 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (208 aa)
	PTPRR	Receptor-type tyrosine-protein phosphatase R isoform X1. (655 aa)
	MYOC	Myocilin. (490 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERBB3	EREG	A0A2U3XBG8	A0A2U3XEH8	Receptor tyrosine-protein kinase erbB-3.	Proepiregulin.	0.977
ERBB3	HBEGF	A0A2U3XBG8	A0A2U3XJ45	Receptor tyrosine-protein kinase erbB-3.	Proheparin-binding EGF-like growth factor.	0.869
ERBB3	LOC102741253	A0A2U3XBG8	A0A2U3XEW8	Receptor tyrosine-protein kinase erbB-3.	Amphiregulin-like.	0.941
ERBB3	TGFA	A0A2U3XBG8	A0A2U3X9B7	Receptor tyrosine-protein kinase erbB-3.	Protransforming growth factor alpha.	0.966
EREG	ERBB3	A0A2U3XEH8	A0A2U3XBG8	Proepiregulin.	Receptor tyrosine-protein kinase erbB-3.	0.977
EREG	HBEGF	A0A2U3XEH8	A0A2U3XJ45	Proepiregulin.	Proheparin-binding EGF-like growth factor.	0.846
EREG	LOC102741253	A0A2U3XEH8	A0A2U3XEW8	Proepiregulin.	Amphiregulin-like.	0.897
EREG	TGFA	A0A2U3XEH8	A0A2U3X9B7	Proepiregulin.	Protransforming growth factor alpha.	0.800
HBEGF	ERBB3	A0A2U3XJ45	A0A2U3XBG8	Proheparin-binding EGF-like growth factor.	Receptor tyrosine-protein kinase erbB-3.	0.869
HBEGF	EREG	A0A2U3XJ45	A0A2U3XEH8	Proheparin-binding EGF-like growth factor.	Proepiregulin.	0.846
HBEGF	LOC102741253	A0A2U3XJ45	A0A2U3XEW8	Proheparin-binding EGF-like growth factor.	Amphiregulin-like.	0.668
HBEGF	TGFA	A0A2U3XJ45	A0A2U3X9B7	Proheparin-binding EGF-like growth factor.	Protransforming growth factor alpha.	0.710
LOC102741253	ERBB3	A0A2U3XEW8	A0A2U3XBG8	Amphiregulin-like.	Receptor tyrosine-protein kinase erbB-3.	0.941
LOC102741253	EREG	A0A2U3XEW8	A0A2U3XEH8	Amphiregulin-like.	Proepiregulin.	0.897
LOC102741253	HBEGF	A0A2U3XEW8	A0A2U3XJ45	Amphiregulin-like.	Proheparin-binding EGF-like growth factor.	0.668
LOC102741253	TGFA	A0A2U3XEW8	A0A2U3X9B7	Amphiregulin-like.	Protransforming growth factor alpha.	0.770
TGFA	ERBB3	A0A2U3X9B7	A0A2U3XBG8	Protransforming growth factor alpha.	Receptor tyrosine-protein kinase erbB-3.	0.966
TGFA	EREG	A0A2U3X9B7	A0A2U3XEH8	Protransforming growth factor alpha.	Proepiregulin.	0.800
TGFA	HBEGF	A0A2U3X9B7	A0A2U3XJ45	Protransforming growth factor alpha.	Proheparin-binding EGF-like growth factor.	0.710
TGFA	LOC102741253	A0A2U3X9B7	A0A2U3XEW8	Protransforming growth factor alpha.	Amphiregulin-like.	0.770