STRINGSTRING
IL7 IL7 LEF1 LEF1 IFNA14 IFNA14 LOC102731864 LOC102731864 WNT10B WNT10B SEMA4A SEMA4A LOC102742177 LOC102742177 LOC102727190 LOC102727190 LOC102748045 LOC102748045 CCR9 CCR9 LOC102744509 LOC102744509 RAB44 RAB44 NCSTN NCSTN STAT3 STAT3 INS INS LOC102730318 LOC102730318 LOC102740348 LOC102740348 LOC102731636 LOC102731636 SP3 SP3 LOC102745732 LOC102745732 PKNOX1 PKNOX1 ABL1 ABL1 CRTAM CRTAM BCL3 BCL3 LOC102737749 LOC102737749 LEP LEP LCP1 LCP1 CD28 CD28 LOC102749512 LOC102749512 ZNF683 ZNF683 PSMB11 PSMB11 CCR7 CCR7 LOC102738024 LOC102738024 IFNE IFNE HLX HLX TBX21 TBX21 LY9 LY9 SLAMF7 SLAMF7 FCER1G FCER1G FKBP1B FKBP1B FOXP3 FOXP3 PTPN2 PTPN2 BATF BATF IRF4 IRF4 FZD7 FZD7 IRF1 IRF1 PRKCQ PRKCQ GBA GBA LOC102741183 LOC102741183 ELF4 ELF4 SASH3 SASH3 PREX1 PREX1 F2RL1 F2RL1 TRAF3IP2 TRAF3IP2 MTOR MTOR TNFSF8 TNFSF8 CD83 CD83 RAG2 RAG2 RAG1 RAG1 CRIP3 CRIP3 SRF SRF LOC102730452 LOC102730452 FADD FADD LOC102738400 LOC102738400 P2RX7 P2RX7 IFNK IFNK RAB7L1 RAB7L1 EGR1 EGR1 BCL6 BCL6 NRARP NRARP FUT7 FUT7 IL18R1 IL18R1 LAG3 LAG3 CD4 CD4 ITGAL ITGAL IL2 IL2 IL21 IL21 CLEC4A CLEC4A WAS WAS LOC102745161 LOC102745161 STAT5B STAT5B ZBTB1 ZBTB1 LOC102727326 LOC102727326 TP53 TP53 KITLG KITLG STOML2 STOML2 CCL21 CCL21 RSAD2 RSAD2 LOC102743949 LOC102743949 NLRC3 NLRC3 ATG5 ATG5 ZFP36L1 ZFP36L1 TOX TOX NDFIP1 NDFIP1 NKG7 NKG7 EOMES EOMES CXADR CXADR LIG4 LIG4 IL23A IL23A CD8A CD8A CD74 CD74 ENTPD7 ENTPD7 GATA3 GATA3 LOC102739213 LOC102739213 IL12B IL12B AMICA1 AMICA1 AZI2 AZI2 CD3D CD3D ATF2 ATF2 DLL4 DLL4 ZFP36L2 ZFP36L2 SLA2 SLA2 RASGRP1 RASGRP1 IL6 IL6 LOC102743741 LOC102743741 DLG2 DLG2 CORO1A CORO1A ZAP70 ZAP70 CLEC4G CLEC4G NKX2-3 NKX2-3 PATZ1 PATZ1 PTGER4 PTGER4 MSN MSN PRR7 PRR7 IFNB1 IFNB1 LOC102750324 LOC102750324 LOC102747757 LOC102747757 PTEN PTEN LOC102737670 LOC102737670 RAB27A RAB27A IDO1 IDO1 FGL2 FGL2 GPR18 GPR18 FOXN1 FOXN1 LOC102749335 LOC102749335 ITK ITK PSMB10 PSMB10 LFNG LFNG CARD11 CARD11 ARMC5 ARMC5 CHD7 CHD7 WNT1 WNT1 TREML2 TREML2 CCND3 CCND3 PTPN22 PTPN22 TNFAIP8L2 TNFAIP8L2 CBLB CBLB LRRC1 LRRC1 HSPD1 HSPD1 JMJD6 JMJD6 NCK1 NCK1 B2M B2M
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SEMA4Asemaphorin-4A-like. (350 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
CCR9c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
LOC102744509Autophagy protein 5-like. (78 aa)
RAB44Ras-related protein Rab-44. (795 aa)
NCSTNNicastrin. (602 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102740348Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
LOC102731636Zinc finger protein Aiolos-like isoform X1. (262 aa)
SP3Transcription factor Sp3-like. (751 aa)
LOC102745732Leucine-rich repeat-containing protein 1-like. (92 aa)
PKNOX1Homeobox protein PKNOX1 isoform X1. (436 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
CRTAMCytotoxic and regulatory T-cell molecule. (366 aa)
BCL3B-cell lymphoma 3 protein. (407 aa)
LOC102737749Transcription factor RelB-like. (167 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
LCP1Plastin-2-like. (507 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
LOC102749512Protein NLRC3-like. (756 aa)
ZNF683LOW QUALITY PROTEIN: zinc finger protein 683. (472 aa)
PSMB11Proteasome subunit beta. (285 aa)
CCR7c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
LOC102738024CTP synthase 1-like. (190 aa)
IFNEInterferon epsilon. (208 aa)
HLXH2.0-like homeobox protein. (415 aa)
TBX21T-box transcription factor TBX21. (535 aa)
LY9T-lymphocyte surface antigen Ly-9. (642 aa)
SLAMF7SLAM family member 7 isoform X1. (338 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
IRF4Interferon regulatory factor 4 isoform X1. (451 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
IRF1Interferon regulatory factor. (322 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
GBAGlucosylceramidase. (536 aa)
LOC102741183Roquin-1-like. (688 aa)
ELF4ETS-related transcription factor Elf-4. (657 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1642 aa)
F2RL1Proteinase-activated receptor 2. (415 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (563 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
TNFSF8Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
CD83CD83 antigen isoform X1. (199 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
CRIP3Cysteine-rich protein 3. (204 aa)
SRFSerum response factor. (508 aa)
LOC102730452semaphorin-4A-like; Belongs to the semaphorin family. (436 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
LOC102738400Annexin. (345 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
IFNKInterferon kappa. (208 aa)
RAB7L1Ras-related protein Rab-7L1 isoform X1. (203 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
FUT7Alpha-(1,3)-fucosyltransferase 7. (342 aa)
IL18R1Interleukin-18 receptor 1. (540 aa)
LAG3Lymphocyte activation gene 3 protein. (389 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
CLEC4ALOW QUALITY PROTEIN: C-type lectin domain family 4 member A. (236 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa)
LOC102727326Cathepsin L1-like isoform X1; Belongs to the peptidase C1 family. (334 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (356 aa)
CCL21c-C motif chemokine 21. (137 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (245 aa)
LOC102743949Plastin-2-like. (119 aa)
NLRC3Protein NLRC3. (330 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1 isoform X1. (338 aa)
TOXThymocyte selection-associated high mobility group box protein TOX. (487 aa)
NDFIP1NEDD4 family-interacting protein 1 isoform X1. (221 aa)
NKG7Protein NKG7. (165 aa)
EOMESEomesodermin homolog isoform X2. (571 aa)
CXADRCoxsackievirus and adenovirus receptor homolog isoform X1. (365 aa)
LIG4DNA ligase. (911 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (213 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7-like; Belongs to the GDA1/CD39 NTPase family. (413 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
AMICA1Junctional adhesion molecule-like. (322 aa)
AZI25-azacytidine-induced protein 2. (393 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
ZFP36L2Zinc finger protein 36, C3H1 type-like 2-like. (491 aa)
SLA2Src-like-adapter 2. (276 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC102743741Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
NKX2-3Homeobox protein Nkx-2.3. (307 aa)
PATZ1POZ-, AT hook-, and zinc finger-containing protein 1 isoform X1. (687 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
MSNLOW QUALITY PROTEIN: moesin. (546 aa)
PRR7Proline-rich protein 7 isoform X2. (269 aa)
IFNB1Interferon beta. (182 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
RAB27ARas-related protein Rab-27A. (221 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (394 aa)
FGL2Fibroleukin. (440 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (331 aa)
FOXN1Forkhead box protein N1 isoform X1. (641 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
ITKTyrosine-protein kinase. (486 aa)
PSMB10Proteasome subunit beta. (273 aa)
LFNGbeta-1,3-N-acetylglucosaminyltransferase lunatic fringe. (275 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
ARMC5Armadillo repeat-containing protein 5. (943 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2429 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TREML2Trem-like transcript 2 protein. (332 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (805 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2. (184 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
LRRC1Leucine-rich repeat-containing protein 1. (242 aa)
HSPD160 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (573 aa)
JMJD6Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X1. (414 aa)
NCK1Cytoplasmic protein. (377 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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