STRINGSTRING
IFNE IFNE LAT2 LAT2 LOC102738024 LOC102738024 FLT3 FLT3 LOC102736516 LOC102736516 LOC102735415 LOC102735415 EXOSC6 EXOSC6 EXO1 EXO1 BCL3 BCL3 NOTCH2 NOTCH2 NTRK1 NTRK1 ABL1 ABL1 DLL1 DLL1 MEF2C MEF2C CD40LG CD40LG BANK1 BANK1 IFNA14 IFNA14 LOC102750030 LOC102750030 LOC102732263 LOC102732263 LOC102751021 LOC102751021 LOC102731864 LOC102731864 LOC102742177 LOC102742177 POU2AF1 POU2AF1 LOC102732741 LOC102732741 GPR97 GPR97 LOC102740348 LOC102740348 LOC102731636 LOC102731636 SP3 SP3 LRRC8A LRRC8A ITM2A ITM2A POU1F1 POU1F1 TPD52 TPD52 LEF1 LEF1 IL7 IL7 SWAP70 SWAP70 EXOSC3 EXOSC3 CDH17 CDH17 CARD11 CARD11 LFNG LFNG EP300 EP300 LYL1 LYL1 CD22 CD22 EZH2 EZH2 SKAP2 SKAP2 LAX1 LAX1 CD79A CD79A PTEN PTEN LOC102747757 LOC102747757 LOC102750324 LOC102750324 LOC102747471 LOC102747471 IFNB1 IFNB1 KIAA1841 KIAA1841 TSHR TSHR NKX2-3 NKX2-3 CD19 CD19 ST3GAL1 ST3GAL1 IL4 IL4 LOC102728733 LOC102728733 SASH3 SASH3 TRAF3IP2 TRAF3IP2 RAG2 RAG2 RAG1 RAG1 LOC102728321 LOC102728321 MSH6 MSH6 MSH2 MSH2 IFNK IFNK BCL6 BCL6 CD79B CD79B BTK BTK LOC102729240 LOC102729240 PHB2 PHB2 BAK1 BAK1 IL21 IL21 STAT5B STAT5B ERCC1 ERCC1 ZBTB1 ZBTB1 TP53 TP53 GPS2 GPS2 CD40 CD40 LIG4 LIG4 LGALS1 LGALS1 CXCR5 CXCR5 RNF168 RNF168 ITFG2 ITFG2 MFNG MFNG RASGRP1 RASGRP1 CD180 CD180 LOC102745380 LOC102745380 FOXP3 FOXP3 MS4A1 MS4A1 BATF BATF CLCF1 CLCF1 TBC1D10C TBC1D10C PTPN2 PTPN2 FZD9 FZD9 IRF8 IRF8 ATM ATM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNEInterferon epsilon. (208 aa)
LAT2Linker for activation of T-cells family member 2. (186 aa)
LOC102738024CTP synthase 1-like. (190 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (984 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
EXOSC6Exosome complex component MTR3. (195 aa)
EXO1LOW QUALITY PROTEIN: exonuclease 1. (793 aa)
BCL3B-cell lymphoma 3 protein. (407 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
BANK1LOW QUALITY PROTEIN: B-cell scaffold protein with ankyrin repeats 1. (634 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102732263Alpha-taxilin-like. (183 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
POU2AF1POU domain class 2-associating factor 1. (286 aa)
LOC102732741uracil-DNA glycosylase-like. (177 aa)
GPR97Probable G-protein coupled receptor 97; Belongs to the G-protein coupled receptor 2 family. (424 aa)
LOC102740348Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
LOC102731636Zinc finger protein Aiolos-like isoform X1. (262 aa)
SP3Transcription factor Sp3-like. (751 aa)
LRRC8ALeucine-rich repeat-containing protein 8A. (810 aa)
ITM2AIntegral membrane protein 2A isoform X1. (263 aa)
POU1F1POU domain protein. (317 aa)
TPD52Tumor protein D52 isoform X1. (245 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
SWAP70Switch-associated protein 70 isoform X1. (585 aa)
EXOSC3Exosome complex component RRP40 isoform X1. (275 aa)
CDH17Cadherin-17. (831 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
LFNGbeta-1,3-N-acetylglucosaminyltransferase lunatic fringe. (275 aa)
EP300Histone acetyltransferase p300. (2425 aa)
LYL1Protein lyl-1. (245 aa)
CD22B-cell receptor CD22 isoform X1. (844 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
SKAP2Src kinase-associated phosphoprotein 2. (359 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (432 aa)
CD79AB-cell antigen receptor complex-associated protein alpha chain isoform X1. (236 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
IFNB1Interferon beta. (182 aa)
KIAA1841Uncharacterized protein KIAA1841 homolog. (718 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
NKX2-3Homeobox protein Nkx-2.3. (307 aa)
CD19B-lymphocyte antigen CD19. (559 aa)
ST3GAL1CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (342 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
LOC102728733GON-4-like protein-like. (917 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (563 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (951 aa)
IFNKInterferon kappa. (208 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
CD79BB-cell antigen receptor complex-associated protein beta chain isoform X1. (222 aa)
BTKTyrosine-protein kinase. (659 aa)
LOC102729240CCAAT/enhancer-binding protein gamma-like. (145 aa)
PHB2Prohibitin. (299 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
ERCC1DNA excision repair protein ERCC-1. (293 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
GPS2G protein pathway suppressor 2 isoform X1. (327 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (272 aa)
LIG4DNA ligase. (911 aa)
LGALS1Galectin. (135 aa)
CXCR5c-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (377 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (472 aa)
ITFG2Integrin-alpha FG-GAP repeat-containing protein 2. (444 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
CD180CD180 antigen. (661 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
MS4A1B-lymphocyte antigen CD20. (297 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
TBC1D10CCarabin-like. (446 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
IRF8Interferon regulatory factor 8. (426 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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