(29 nodes) Cellular response to glucose starvation network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

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Your Input:
	FOXO3	Forkhead box protein O3. (672 aa)
	NIM1K	Serine/threonine-protein kinase NIM1; Belongs to the protein kinase superfamily. (436 aa)
	ATF4	Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	SESN3	Sestrin-3 isoform X1. (492 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform X1. (590 aa)
	MYBBP1A	Myb-binding protein 1A isoform X1. (1332 aa)
	TBL2	Transducin beta-like protein 2. (351 aa)
	PRKAG1	5'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	SIK2	Serine/threonine-protein kinase SIK2. (914 aa)
	SH3GLB1	endophilin-B1 isoform X1. (393 aa)
	KPTN	Kaptin. (435 aa)
	SESN2	Sestrin-2. (481 aa)
	LOC102747943	UPF0536 protein C12orf66 homolog. (445 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	ATG14	Beclin 1-associated autophagy-related key regulator. (492 aa)
	NUAK2	NUAK family SNF1-like kinase 2. (633 aa)
	IMPACT	Protein IMPACT isoform X1. (318 aa)
	LOC102738608	Asparagine synthetase [glutamine-hydrolyzing]-like isoform X1. (561 aa)
	HSPA5	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1114 aa)
	ITFG2	Integrin-alpha FG-GAP repeat-containing protein 2. (444 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (437 aa)
	PRKAG2	5'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
	LOC102748583	5'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
	SESN1	Sestrin-1 isoform X1. (551 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	EIF2AK3	A0A2U3XET2	A0A2U3YBY0	Cyclic AMP-dependent transcription factor ATF-4.	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	0.943
ATF4	HSPA5	A0A2U3XET2	A0A2U3YKM0	Cyclic AMP-dependent transcription factor ATF-4.	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family.	0.860
ATF4	LOC102738608	A0A2U3XET2	A0A2U3YIY7	Cyclic AMP-dependent transcription factor ATF-4.	Asparagine synthetase [glutamine-hydrolyzing]-like isoform X1.	0.693
ATF4	NFE2L2	A0A2U3XET2	A0A2U3YSZ9	Cyclic AMP-dependent transcription factor ATF-4.	Nuclear factor erythroid 2-related factor 2 isoform X1.	0.484
ATG14	PIK3C3	A0A2U3XYI3	A0A2U3XF68	Beclin 1-associated autophagy-related key regulator.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PRKAA1	A0A2U3XYI3	A0A2U3XPK0	Beclin 1-associated autophagy-related key regulator.	Non-specific serine/threonine protein kinase.	0.587
ATG14	SH3GLB1	A0A2U3XYI3	A0A2U3Y6D7	Beclin 1-associated autophagy-related key regulator.	endophilin-B1 isoform X1.	0.400
EIF2AK3	ATF4	A0A2U3YBY0	A0A2U3XET2	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	Cyclic AMP-dependent transcription factor ATF-4.	0.943
EIF2AK3	HSPA5	A0A2U3YBY0	A0A2U3YKM0	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family.	0.984
EIF2AK3	NFE2L2	A0A2U3YBY0	A0A2U3YSZ9	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	Nuclear factor erythroid 2-related factor 2 isoform X1.	0.931
FOXO3	PRKAA1	A0A2U3XDW8	A0A2U3XPK0	Forkhead box protein O3.	Non-specific serine/threonine protein kinase.	0.922
FOXO3	TP53	A0A2U3XDW8	A0A2U3Y5G3	Forkhead box protein O3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.707
HSPA5	ATF4	A0A2U3YKM0	A0A2U3XET2	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family.	Cyclic AMP-dependent transcription factor ATF-4.	0.860
HSPA5	EIF2AK3	A0A2U3YKM0	A0A2U3YBY0	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family.	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	0.984
HSPA5	NFE2L2	A0A2U3YKM0	A0A2U3YSZ9	78 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family.	Nuclear factor erythroid 2-related factor 2 isoform X1.	0.402
ITFG2	KPTN	A0A2U3YDV3	A0A2U3Y6Y8	Integrin-alpha FG-GAP repeat-containing protein 2.	Kaptin.	0.999
ITFG2	LOC102747943	A0A2U3YDV3	A0A2U3XKI8	Integrin-alpha FG-GAP repeat-containing protein 2.	UPF0536 protein C12orf66 homolog.	0.999
ITFG2	SESN1	A0A2U3YDV3	A0A2U3XDH2	Integrin-alpha FG-GAP repeat-containing protein 2.	Sestrin-1 isoform X1.	0.555
ITFG2	SESN2	A0A2U3YDV3	A0A2U3Y886	Integrin-alpha FG-GAP repeat-containing protein 2.	Sestrin-2.	0.731
ITFG2	SESN3	A0A2U3YDV3	A0A2U3YMZ8	Integrin-alpha FG-GAP repeat-containing protein 2.	Sestrin-3 isoform X1.	0.423