STRINGSTRING
BACE2 BACE2 INPP5K INPP5K FOXK2 FOXK2 RAF1 RAF1 LOC102749673 LOC102749673 NCOA5 NCOA5 LOC102731486 LOC102731486 CARTPT CARTPT SLC2A4 SLC2A4 PLSCR3 PLSCR3 GAS6 GAS6 PCK2 PCK2 LOC102745161 LOC102745161 HIF1A HIF1A PTCH1 PTCH1 IGF1R IGF1R HNF1A HNF1A NUCKS1 NUCKS1 CAV3 CAV3 GCK GCK AGER AGER ADRA2A ADRA2A PTPN11 PTPN11 RFX6 RFX6 HNF4A HNF4A ZBTB20 ZBTB20 LOC102736357 LOC102736357 VGF VGF TRA2B TRA2B PRKAA1 PRKAA1 HK3 HK3 CRY1 CRY1 PYGL PYGL STXBP3 STXBP3 TRPV4 TRPV4 IL6 IL6 FFAR2 FFAR2 FFAR1 FFAR1 ADIPOR1 ADIPOR1 MBD5 MBD5 LOC102750844 LOC102750844 ASPSCR1 ASPSCR1 GCGR GCGR PTPN2 PTPN2 RPH3AL RPH3AL RMI1 RMI1 SESN3 SESN3 RAB11FIP2 RAB11FIP2 PIK3CA PIK3CA NR1D1 NR1D1 DBH DBH GNB2L1 GNB2L1 GCG GCG PARK7 PARK7 LOC102736516 LOC102736516 SLC39A14 SLC39A14 PRCP PRCP LOC102743139 LOC102743139 CNR1 CNR1 PDK2 PDK2 LOC102730307 LOC102730307 PDX1 PDX1 LRRC8A LRRC8A GPER1 GPER1 SLC37A4 SLC37A4 KLF7 KLF7 LOC102726566 LOC102726566 G6PC2 G6PC2 LOC102731850 LOC102731850 WFS1 WFS1 INS INS FOXA3 FOXA3 STAT3 STAT3 LOC102746665 LOC102746665 LOC102746964 LOC102746964 CRY2 CRY2 LOC102731352 LOC102731352 PCK1 PCK1 LOC102747944 LOC102747944 LOC102727190 LOC102727190 PDK4 PDK4 LOC102731463 LOC102731463 LOC102751021 LOC102751021 LOC102744936 LOC102744936 GCKR GCKR ALOX5 ALOX5 LOC102740749 LOC102740749 PAX6 PAX6 FOXO3 FOXO3 FOXA1 FOXA1 DHPS DHPS SLC12A6 SLC12A6 GPR116 GPR116 LOC102739837 LOC102739837 LRRC8D LRRC8D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (445 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (452 aa)
FOXK2Forkhead box protein K2. (540 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
NCOA5Nuclear receptor coactivator 5. (526 aa)
LOC102731486Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (116 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (287 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2. (640 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
PTCH1Protein patched homolog 1. (1301 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (631 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1. (243 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
GCKPhosphotransferase. (391 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
ADRA2Aalpha-2A adrenergic receptor. (350 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
RFX6DNA-binding protein RFX6. (928 aa)
HNF4AHepatocyte nuclear factor 4-alpha. (399 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X2. (668 aa)
LOC102736357Cytochrome b5 reductase 4-like isoform X1. (520 aa)
VGFNeurosecretory protein VGF. (617 aa)
TRA2BTransformer-2 protein homolog beta. (288 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
HK3Hexokinase-3. (954 aa)
CRY1Cryptochrome-1. (587 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (742 aa)
IL6Interleukin-6 isoform X1. (212 aa)
FFAR2Free fatty acid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (329 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
MBD5methyl-CpG-binding domain protein 5 isoform X1. (1733 aa)
LOC102750844Uncharacterized protein C10orf118 homolog. (907 aa)
ASPSCR1Tether containing UBX domain for GLUT4. (539 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (474 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (306 aa)
RMI1recQ-mediated genome instability protein 1. (638 aa)
SESN3Sestrin-3 isoform X1. (492 aa)
RAB11FIP2Rab11 family-interacting protein 2-like. (512 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
DBHDopamine beta-hydroxylase. (274 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
GCGGlucagon isoform X1. (180 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
SLC39A14Zinc transporter ZIP14 isoform X1. (490 aa)
PRCPLysosomal Pro-X carboxypeptidase. (497 aa)
LOC102743139SID1 transmembrane family member 2-like. (615 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
LOC102730307CUB and sushi domain-containing protein 1-like. (828 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
LRRC8ALeucine-rich repeat-containing protein 8A. (810 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
SLC37A4Glucose-6-phosphate translocase isoform X2. (429 aa)
KLF7Krueppel-like factor 7-like isoform X1. (302 aa)
LOC102726566Fibrillin-1-like. (1491 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
WFS1Wolframin-like. (882 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FOXA3Hepatocyte nuclear factor 3-gamma. (350 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
LOC102746665SID1 transmembrane family member 2-like. (244 aa)
LOC102746964Sodium/potassium/calcium exchanger 6, mitochondrial-like. (200 aa)
CRY2Cryptochrome-2. (527 aa)
LOC102731352Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
LOC102747944Potassium voltage-gated channel subfamily B member 1-like. (189 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
LOC102731463Transcription factor AP-2-beta-like. (180 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102744936Fatty acid-binding protein, epidermal-like. (81 aa)
GCKRLOW QUALITY PROTEIN: glucokinase (Hexokinase 4) regulator. (482 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
LOC102740749Phosphotransferase; Belongs to the hexokinase family. (82 aa)
PAX6Paired box protein Pax-6. (221 aa)
FOXO3Forkhead box protein O3. (672 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (473 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
SLC12A6Solute carrier family 12 member 6 isoform X1. (1150 aa)
GPR116Probable G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
LOC102739837Glucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
LRRC8DLeucine-rich repeat-containing protein 8D. (858 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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