(30 nodes) Regulation of muscle adaptation network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	FOXO3	Forkhead box protein O3. (672 aa)
	TWF1	Twinfilin-1 isoform X2. (357 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	MYOG	Myogenin. (224 aa)
	TNNC1	Troponin C, slow skeletal and cardiac muscles. (161 aa)
	LOC102734862	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	LOC102735672	Myotrophin-like. (118 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	LOC102751226	Peptidase inhibitor 16-like. (304 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	LMCD1	LIM and cysteine-rich domains protein 1. (290 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	LOC102732685	Glutaredoxin-3-like; Belongs to the universal ribosomal protein uL11 family. (355 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (358 aa)
	LOC102744643	Short transient receptor potential channel 3-like. (453 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
	TRPC3	Short transient receptor potential channel 3-like. (592 aa)
	SGCA	Alpha-sarcoglycan. (386 aa)
	HDAC4	Histone deacetylase 4-like. (667 aa)
	NOL3	Nucleolar protein 3. (212 aa)
	TMEM8C	Protein myomaker. (221 aa)
	PARP1	Poly [ADP-ribose] polymerase. (686 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform X1. (487 aa)
	LOC102749794	Glutaredoxin-3-like. (288 aa)
	LOC102743250	Transcription factor GATA-5-like. (300 aa)
	GSK3A	Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
	LOC102727186	Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
	LOC102730732	Sarcalumenin-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (379 aa)
	LMNA	prelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
	LOC102730020	Myosin-7-like. (703 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV3	MYOG	A0A2U3XYT3	A0A2U3XJX0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myogenin.	0.522
CAV3	SGCA	A0A2U3XYT3	A0A2U3YAQ5	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Alpha-sarcoglycan.	0.665
FOXO3	SMAD4	A0A2U3XDW8	A0A2U3XTK1	Forkhead box protein O3.	Mothers against decapentaplegic homolog.	0.898
HDAC4	MEF2A	A0A2U3YBV8	A0A2U3YQ65	Histone deacetylase 4-like.	Myocyte-specific enhancer factor 2A isoform X1.	0.650
HDAC4	MYOG	A0A2U3YBV8	A0A2U3XJX0	Histone deacetylase 4-like.	Myogenin.	0.573
LMCD1	LOC102743250	A0A2U3XYX6	A0A2U3Z0L8	LIM and cysteine-rich domains protein 1.	Transcription factor GATA-5-like.	0.558
LMNA	LOC102730020	A0A2U3Z6T9	A0A2U3Z8B7	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Myosin-7-like.	0.455
LMNA	MYOG	A0A2U3Z6T9	A0A2U3XJX0	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Myogenin.	0.403
LMNA	SGCA	A0A2U3Z6T9	A0A2U3YAQ5	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	Alpha-sarcoglycan.	0.492
LOC102727186	LOC102730020	A0A2U3Z5T9	A0A2U3Z8B7	Heart- and neural crest derivatives-expressed protein 2-like.	Myosin-7-like.	0.472
LOC102727186	LOC102743250	A0A2U3Z5T9	A0A2U3Z0L8	Heart- and neural crest derivatives-expressed protein 2-like.	Transcription factor GATA-5-like.	0.593
LOC102730020	LMNA	A0A2U3Z8B7	A0A2U3Z6T9	Myosin-7-like.	prelamin-A/C isoform X1; Belongs to the intermediate filament family.	0.455
LOC102730020	LOC102727186	A0A2U3Z8B7	A0A2U3Z5T9	Myosin-7-like.	Heart- and neural crest derivatives-expressed protein 2-like.	0.472
LOC102730020	MYOG	A0A2U3Z8B7	A0A2U3XJX0	Myosin-7-like.	Myogenin.	0.672
LOC102730020	TNNC1	A0A2U3Z8B7	A0A2U3XKD1	Myosin-7-like.	Troponin C, slow skeletal and cardiac muscles.	0.475
LOC102734862	SLC9A1	A0A2U3XNQ7	A0A2U3Y7C1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.946
LOC102735672	TWF1	A0A2U3XSG3	A0A2U3XFT0	Myotrophin-like.	Twinfilin-1 isoform X2.	0.424
LOC102743250	LMCD1	A0A2U3Z0L8	A0A2U3XYX6	Transcription factor GATA-5-like.	LIM and cysteine-rich domains protein 1.	0.558
LOC102743250	LOC102727186	A0A2U3Z0L8	A0A2U3Z5T9	Transcription factor GATA-5-like.	Heart- and neural crest derivatives-expressed protein 2-like.	0.593
LOC102744643	TRPC3	A0A2U3Y3E8	A0A2U3Y9Q8	Short transient receptor potential channel 3-like.	Short transient receptor potential channel 3-like.	0.929