STRINGSTRING
FBXW7 FBXW7 LOC102739837 LOC102739837 MAP1LC3A MAP1LC3A HM13 HM13 DNM1L DNM1L RNF20 RNF20 SPOPL SPOPL SUMO2 SUMO2 UBE2L6 UBE2L6 ERBB3 ERBB3 SNCAIP SNCAIP GLMN GLMN PA2G4 PA2G4 FANCL FANCL PAX6 PAX6 RTN1 RTN1 JKAMP JKAMP TXNIP TXNIP LAPTM5 LAPTM5 UBXN1 UBXN1 ASB4 ASB4 TMEM173 TMEM173 KCNH2 KCNH2 CUL1 CUL1 CAMLG CAMLG UBE2B UBE2B SPG20 SPG20 LOC102728200 LOC102728200 NLK NLK CEBPB CEBPB AXIN1 AXIN1 PRKAR2B PRKAR2B NFKBIA NFKBIA DDRGK1 DDRGK1 GABARAPL1 GABARAPL1 UBOX5 UBOX5 UBE2K UBE2K CCT2 CCT2 UBE2J2 UBE2J2 ISG15 ISG15 LOC102750322 LOC102750322 APBB1 APBB1 SMC6 SMC6 DET1 DET1 PRKAR2A PRKAR2A PRR7 PRR7 CACYBP CACYBP FZD5 FZD5 VCL VCL LOC102741278 LOC102741278 PATZ1 PATZ1 LOC102728823 LOC102728823 LOC102729936 LOC102729936 UBE2J1 UBE2J1 PACRGL PACRGL LOC102734657 LOC102734657 LOC102729636 LOC102729636 BAG1 BAG1 SUMO1 SUMO1 SCAMP3 SCAMP3 TRIP4 TRIP4 LOC102730138 LOC102730138 EGR2 EGR2 UBE2C UBE2C AUP1 AUP1 LOC102748670 LOC102748670 UBASH3A UBASH3A TANK TANK LTBR LTBR BAG2 BAG2 SLC22A18 SLC22A18 CACUL1 CACUL1 STAM STAM LOC102726900 LOC102726900 RALA RALA TRAF6 TRAF6 RAD18 RAD18 PRKACB PRKACB UBE2W UBE2W PRKAR1B PRKAR1B ANAPC2 ANAPC2 ARRDC1 ARRDC1 DLG3 DLG3 MUL1 MUL1 PINK1 PINK1 HSPA1L HSPA1L BAG6 BAG6 RTN2 RTN2 HIF1A HIF1A LOC102734190 LOC102734190 RNF31 RNF31 PIAS4 PIAS4 TP53 TP53 WRAP53 WRAP53 GABARAP GABARAP LOC102737997 LOC102737997 JUN JUN TRIB1 TRIB1 USP2 USP2 BLZF1 BLZF1 HSPA9 HSPA9 LOC102737595 LOC102737595 KDM4A KDM4A LOC102736082 LOC102736082 MDM2 MDM2 LOC102745369 LOC102745369 RB1 RB1 PIAS2 PIAS2 BCL10 BCL10 PML PML STAT2 STAT2 LOC102729663 LOC102729663 CRK CRK BAG4 BAG4 CHEK2 CHEK2 UBE2A UBE2A LOC102738314 LOC102738314 LOC102748381 LOC102748381 MFHAS1 MFHAS1 PRKAR1A PRKAR1A GSK3B GSK3B LOC102747594 LOC102747594 USP25 USP25 ANKRD32 ANKRD32 LAPTM4B LAPTM4B LOC102740715 LOC102740715 LOC102729256 LOC102729256 LOC102728857 LOC102728857 HGS HGS FAM162A FAM162A DTX3L DTX3L UBE2L3 UBE2L3 LOC102750756 LOC102750756 LOC102740611 LOC102740611 RFFL RFFL PSMA3 PSMA3 LOC102730789 LOC102730789 HSPA5 HSPA5 NDUFS2 NDUFS2 LOC102742823 LOC102742823 RTN3 RTN3 LOC102742022 LOC102742022 USP13 USP13 PPARGC1A PPARGC1A MC1R MC1R OTUB1 OTUB1 LOC102731310 LOC102731310 TNFRSF14 TNFRSF14 SPOP SPOP LOC102729387 LOC102729387 TSG101 TSG101 LOC102742137 LOC102742137 LOC102741529 LOC102741529 FZD4 FZD4 SUMO3 SUMO3 LOC102746625 LOC102746625 UBA52 UBA52 LOC102737840 LOC102737840 FAF2 FAF2 AMBRA1 AMBRA1 LOC102747337 LOC102747337 LOC102730703 LOC102730703 UBE2G1 UBE2G1 DERL1 DERL1 HSPBP1 HSPBP1 BAG5 BAG5 NEK6 NEK6 RNF34 RNF34 CBS CBS PIAS1 PIAS1 CASP8 CASP8 UBE2T UBE2T LOC102750596 LOC102750596 LOC102750017 LOC102750017 WFS1 WFS1 LOC102730318 LOC102730318 LOC102730835 LOC102730835 LOC102726381 LOC102726381 LOC102728901 LOC102728901 FBXW9 FBXW9 LOC102730420 LOC102730420 BOK BOK LOC102732749 LOC102732749 FOXO1 FOXO1 MYOD1 MYOD1 RNF40 RNF40 LOC102736958 LOC102736958 CDKN1A CDKN1A LOC102733647 LOC102733647 LOC102749847 LOC102749847 LOC102746862 LOC102746862 LOC102750518 LOC102750518 LOC102734169 LOC102734169 LOC102734861 LOC102734861 LOC102749739 LOC102749739 CUL4A CUL4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
LOC102739837Glucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
MAP1LC3AMicrotubule-associated proteins 1A/1B light chain 3A isoform X1. (121 aa)
HM13Minor histocompatibility antigen H13 isoform X1. (427 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
SPOPLSpeckle-type POZ protein-like isoform X1. (392 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
UBE2L6ubiquitin/ISG15-conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
SNCAIPSynphilin-1 isoform X1. (966 aa)
GLMNGlomulin. (521 aa)
PA2G4Proliferation-associated protein 2G4. (394 aa)
FANCLE3 ubiquitin-protein ligase FANCL isoform X1. (375 aa)
PAX6Paired box protein Pax-6. (221 aa)
RTN1Reticulon. (777 aa)
JKAMPJNK1/MAPK8-associated membrane protein isoform X3. (311 aa)
TXNIPThioredoxin-interacting protein-like. (391 aa)
LAPTM5Lysosomal-associated transmembrane protein 5. (263 aa)
UBXN1UBX domain-containing protein 1 isoform X2. (295 aa)
ASB4Ankyrin repeat and SOCS box protein 4. (426 aa)
TMEM173Stimulator of interferon genes protein. (378 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (819 aa)
CUL1Cullin-1; Belongs to the cullin family. (327 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
UBE2BUbiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SPG20Spartin isoform X1. (691 aa)
LOC102728200ubiquitin-40S ribosomal protein S27a-like. (154 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
AXIN1Axin-1 isoform X1. (867 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (417 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
DDRGK1DDRGK domain-containing protein 1. (315 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1. (117 aa)
UBOX5RING finger protein 37 isoform X1. (541 aa)
UBE2KUbiquitin-conjugating enzyme E2 K isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
CCT2T-complex protein 1 subunit beta. (543 aa)
UBE2J2Ubiquitin-conjugating enzyme E2 J2. (259 aa)
ISG15Ubiquitin-like protein ISG15. (169 aa)
LOC102750322polyubiquitin-B-like. (153 aa)
APBB1Amyloid beta A4 precursor protein-binding family B member 1 isoform X1. (710 aa)
SMC6Structural maintenance of chromosomes protein 6. (1097 aa)
DET1DET1 homolog. (550 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (391 aa)
PRR7Proline-rich protein 7 isoform X2. (269 aa)
CACYBPCalcyclin-binding protein. (230 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
VCLVinculin isoform X1. (1134 aa)
LOC102741278Sodium channel protein type 5 subunit alpha-like. (920 aa)
PATZ1POZ-, AT hook-, and zinc finger-containing protein 1 isoform X1. (687 aa)
LOC102728823Ubiquitin-conjugating enzyme E2 L3-like isoform X1. (153 aa)
LOC102729936T-complex protein 1 subunit alpha-like. (556 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (318 aa)
PACRGLPACRG-like protein. (290 aa)
LOC10273465726S proteasome non-ATPase regulatory subunit 1-like. (279 aa)
LOC102729636polyubiquitin-B-like. (77 aa)
BAG1BAG family molecular chaperone regulator 1. (395 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
SCAMP3Secretory carrier-associated membrane protein. (347 aa)
TRIP4Activating signal cointegrator 1. (581 aa)
LOC102730138Microtubule-associated proteins 1A/1B light chain 3 beta 2-like isoform X2. (125 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (469 aa)
UBE2CUbiquitin-conjugating enzyme E2 C isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
AUP1LOW QUALITY PROTEIN: ancient ubiquitous protein 1. (438 aa)
LOC102748670Lysosomal-associated transmembrane protein 4A-like. (233 aa)
UBASH3AUbiquitin-associated and SH3 domain-containing protein A. (337 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
LTBRTumor necrosis factor receptor superfamily member 3 isoform X1. (421 aa)
BAG2BAG family molecular chaperone regulator 2. (211 aa)
SLC22A18Solute carrier family 22 member 18. (424 aa)
CACUL1CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family. (246 aa)
STAMSignal transducing adapter molecule 1 isoform X1. (486 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
RALARas-related protein Ral-A. (206 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RAD18E3 ubiquitin-protein ligase RAD18. (500 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
UBE2WUbiquitin-conjugating enzyme E2 W. (196 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit. (145 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (818 aa)
ARRDC1Arrestin domain-containing protein 1. (431 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (512 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (488 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1163 aa)
RTN2Reticulon. (474 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
LOC102734190Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1080 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (503 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
WRAP53Telomerase Cajal body protein 1. (532 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
LOC102737997Gametogenetin-like. (153 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
TRIB1Tribbles homolog 1. (292 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
BLZF1Golgin-45. (401 aa)
HSPA9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
LOC102737595Small ubiquitin-related modifier. (95 aa)
KDM4ALysine-specific demethylase 4A. (480 aa)
LOC102736082Sorting nexin-9-like. (218 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
LOC102745369Arrestin domain-containing protein 5-like. (186 aa)
RB1Retinoblastoma-associated protein. (846 aa)
PIAS2E3 SUMO-protein ligase PIAS2-like. (612 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
PMLProtein PML. (880 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
LOC102729663Uncharacterized protein C14orf142 homolog. (100 aa)
CRKAdapter molecule crk. (92 aa)
BAG4BAG family molecular chaperone regulator 4. (421 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
UBE2AUbiquitin-conjugating enzyme E2 A isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC102738314Parkin coregulated gene protein-like. (206 aa)
LOC102748381Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like. (618 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1-like. (1052 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC102747594c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
USP25Ubiquitin carboxyl-terminal hydrolase 25-like isoform X1; Belongs to the peptidase C19 family. (1123 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X1. (1057 aa)
LAPTM4BLysosomal-associated transmembrane protein 4B. (226 aa)
LOC102740715Bis(5'-adenosyl)-triphosphatase-like. (163 aa)
LOC102729256TNF receptor-associated factor 3-like. (283 aa)
LOC102728857Probable ATP-dependent RNA helicase DDX58-like. (294 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (781 aa)
FAM162AProtein FAM162A. (155 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (692 aa)
UBE2L3Ubiquitin-conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
LOC10275075614-3-3 protein epsilon-like; Belongs to the 14-3-3 family. (233 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (298 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
LOC102730789TNF receptor-associated factor 3-like. (295 aa)
HSPA578 kDa glucose-regulated protein isoform X2; Belongs to the heat shock protein 70 family. (654 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial. (242 aa)
LOC102742823Cullin-5-like; Belongs to the cullin family. (239 aa)
RTN3Reticulon. (1041 aa)
LOC10274202214-3-3 protein zeta/delta-like isoform X1; Belongs to the 14-3-3 family. (245 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (317 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
LOC102731310Leucine-rich PPR motif-containing protein, mitochondrial-like. (962 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14. (272 aa)
SPOPSpeckle-type POZ protein isoform X1. (374 aa)
LOC102729387F-box only protein 7-like. (300 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (391 aa)
LOC102742137Leucine-rich PPR motif-containing protein, mitochondrial-like. (112 aa)
LOC102741529Leucine-rich PPR motif-containing protein, mitochondrial-like. (231 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SUMO3Small ubiquitin-related modifier. (111 aa)
LOC102746625Lysine-specific demethylase 4A-like. (404 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X3. (128 aa)
LOC102737840NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like. (212 aa)
FAF2FAS-associated factor 2. (445 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1-like. (299 aa)
LOC102747337ubiquitin-40S ribosomal protein S27a-like. (154 aa)
LOC102730703Ubiquitin-associated and SH3 domain-containing protein A-like. (311 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (99 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
HSPBP1Hsp70-binding protein 1 isoform X1. (421 aa)
BAG5BAG family molecular chaperone regulator 5. (448 aa)
NEK6Serine/threonine-protein kinase Nek6. (100 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (373 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (572 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (653 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
UBE2TUbiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
LOC102750596E3 ubiquitin-protein ligase Midline-1-like isoform X1. (338 aa)
LOC102750017Mothers against decapentaplegic homolog 6-like. (181 aa)
WFS1Wolframin-like. (882 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102730835T-complex protein 1 subunit beta-like. (535 aa)
LOC10272638126S proteasome non-ATPase regulatory subunit 1-like. (574 aa)
LOC102728901Gametogenetin-like. (441 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
LOC102730420Cytochrome b-c1 complex subunit 1, mitochondrial-like isoform X1. (481 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
LOC102732749Lysosomal-associated transmembrane protein 4A-like. (197 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (962 aa)
LOC102736958Fetal and adult testis-expressed transcript protein-like. (105 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102733647Tribbles homolog 2-like. (188 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
LOC102746862ubiquitin-40S ribosomal protein S27a-like isoform X1. (156 aa)
LOC102750518Tribbles homolog 3-like. (215 aa)
LOC102734169Gamma-aminobutyric acid receptor-associated protein-like 2-like. (117 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
LOC102749739Ankyrin repeat family A protein 2-like. (135 aa)
CUL4ALOW QUALITY PROTEIN: cullin 4A; Belongs to the cullin family. (326 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (22%) [HD]