STRINGSTRING
KIF18A KIF18A PAG1 PAG1 DLC1 DLC1 LOC102736511 LOC102736511 LRRK2 LRRK2 ADD2 ADD2 CBLB CBLB RET RET RTN4RL2 RTN4RL2 LOC102740749 LOC102740749 CAV2 CAV2 CAV1 CAV1 TREM2 TREM2 LOC102741936 LOC102741936 FAIM2 FAIM2 SMPD2 SMPD2 STX4 STX4 CARD11 CARD11 CDH1 CDH1 RAB5A RAB5A LOC102726679 LOC102726679 LOC102749335 LOC102749335 MALL MALL CLIP3 CLIP3 SULF1 SULF1 TEX101 TEX101 LYPD4 LYPD4 OLR1 OLR1 TLR6 TLR6 TLR1 TLR1 PACSIN2 PACSIN2 PPAP2A PPAP2A LAMTOR5 LAMTOR5 LRP6 LRP6 PRKAR2A PRKAR2A CORO1C CORO1C LOC102741278 LOC102741278 GHSR GHSR SRC SRC LAMTOR4 LAMTOR4 ZAP70 ZAP70 TGFBR2 TGFBR2 TRPC4 TRPC4 CDH15 CDH15 LCK LCK NPHS2 NPHS2 CDH13 CDH13 LOC102751218 LOC102751218 LOC102732272 LOC102732272 EMP2 EMP2 SLC6A4 SLC6A4 BMPR2 BMPR2 LAMTOR3 LAMTOR3 F2R F2R LCP2 LCP2 KCNQ1 KCNQ1 STOML3 STOML3 CAV3 CAV3 LAMTOR2 LAMTOR2 ADRA1A ADRA1A TEK TEK ITGB1 ITGB1 BTK BTK LOC102743402 LOC102743402 TNFRSF1A TNFRSF1A CD4 CD4 ADTRP ADTRP PTCH1 PTCH1 PI4K2A PI4K2A KCND1 KCND1 TNF TNF AKAP5 AKAP5 SLC2A4 SLC2A4 ARID3C ARID3C STOML2 STOML2 EHD2 EHD2 SLC9A1 SLC9A1 KCNA5 KCNA5 CBL CBL THY1 THY1 BMPR1A BMPR1A CXADR CXADR SGCA SGCA BCL10 BCL10 FLOT2 FLOT2 LOC102746703 LOC102746703 LOC102738309 LOC102738309 KCND3 KCND3 ASAH2B ASAH2B MYO1C MYO1C PRKAR1A PRKAR1A HPSE HPSE KCND2 KCND2 PSEN2 PSEN2 HTR2A HTR2A MAPK1 MAPK1 KCNE1 KCNE1 IKBKB IKBKB APP APP PRNP PRNP DAG1 DAG1 BAALC BAALC DLL1 DLL1 SDPR SDPR SERPINH1 SERPINH1 ADRA1B ADRA1B GP2 GP2 LAT2 LAT2 STIM1 STIM1 HCK HCK ARC ARC LOC102744262 LOC102744262 PARK7 PARK7 MAL2 MAL2 LOC102748609 LOC102748609 SMPD1 SMPD1 PRKCDBP PRKCDBP MAL MAL GPM6B GPM6B AQP1 AQP1 CDHR2 CDHR2 FXYD1 FXYD1 LOC102732425 LOC102732425 CBLC CBLC LOC102748816 LOC102748816 LOC102747249 LOC102747249 ORAI1 ORAI1 LOC102727281 LOC102727281 KCNE3 KCNE3 GPR56 GPR56 GPC1 GPC1 MLC1 MLC1 PTRF PTRF NEU2 NEU2 LOC102748833 LOC102748833 LOC102740078 LOC102740078 LOC102740880 LOC102740880 PPAP2C PPAP2C LOC102740770 LOC102740770 CAPN8 CAPN8 LOC102735756 LOC102735756 LOC102727300 LOC102727300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (898 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (434 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1527 aa)
LOC102736511Muscle-related coiled-coil protein-like. (150 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2150 aa)
ADD2Beta-adducin isoform X1. (727 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
RTN4RL2Reticulon-4 receptor-like 2. (420 aa)
LOC102740749Phosphotransferase; Belongs to the hexokinase family. (82 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (315 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (422 aa)
STX4Syntaxin-4; Belongs to the syntaxin family. (297 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (879 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
LOC102726679Protein S100-A10-like; Belongs to the S-100 family. (97 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
MALLMAL-like protein. (153 aa)
CLIP3CAP-Gly domain-containing linker protein 3. (547 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
TEX101Testis-expressed sequence 101 protein. (244 aa)
LYPD4ly6/PLAUR domain-containing protein 4. (246 aa)
OLR1Oxidized low-density lipoprotein receptor 1. (278 aa)
TLR6Toll-like receptor. (794 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons protein 2. (486 aa)
PPAP2ALipid phosphate phosphohydrolase 1 isoform X1. (286 aa)
LAMTOR5Ragulator complex protein LAMTOR5. (91 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (391 aa)
CORO1Ccoronin-1C. (303 aa)
LOC102741278Sodium channel protein type 5 subunit alpha-like. (920 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SRCTyrosine-protein kinase. (536 aa)
LAMTOR4Ragulator complex protein LAMTOR4. (99 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
TRPC4Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
CDH15Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. (169 aa)
LCKTyrosine-protein kinase. (509 aa)
NPHS2Podocin. (377 aa)
CDH13Cadherin-13-like. (512 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
LOC102732272Ragulator complex protein LAMTOR1-like. (152 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
LAMTOR3Ragulator complex protein LAMTOR3. (111 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
STOML3Stomatin-like protein 3. (357 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LAMTOR2Ragulator complex protein LAMTOR2 isoform X1. (125 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
BTKTyrosine-protein kinase. (659 aa)
LOC102743402Annexin. (173 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
ADTRPAndrogen-dependent TFPI-regulating protein. (260 aa)
PTCH1Protein patched homolog 1. (1301 aa)
PI4K2APhosphatidylinositol 4-kinase type 2-alpha. (382 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKAP5A-kinase anchor protein 5. (429 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ARID3CAT-rich interactive domain-containing protein 3C. (413 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (356 aa)
EHD2EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CXADRCoxsackievirus and adenovirus receptor homolog isoform X1. (365 aa)
SGCAAlpha-sarcoglycan. (386 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
LOC102746703Unconventional myosin-Ia-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (619 aa)
LOC102738309Muscle-related coiled-coil protein-like. (242 aa)
KCND3Potassium voltage-gated channel subfamily D member 3. (283 aa)
ASAH2BNeutral ceramidase. (423 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
HPSEHeparanase-like. (376 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (629 aa)
PSEN2Presenilin-2. (115 aa)
HTR2A5-hydroxytryptamine receptor 2A. (263 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1 isoform X2. (124 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
APPAmyloid beta A4 protein. (753 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
DAG1Dystroglycan isoform X1. (891 aa)
BAALCBrain and acute leukemia cytoplasmic protein. (145 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
SDPRSerum deprivation-response protein. (425 aa)
SERPINH1Serpin H1 isoform X3; Belongs to the serpin family. (418 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
GP2Pancreatic secretory granule membrane major glycoprotein GP2. (502 aa)
LAT2Linker for activation of T-cells family member 2. (186 aa)
STIM1Stromal interaction molecule 1. (215 aa)
HCKTyrosine-protein kinase. (504 aa)
ARCActivity-regulated cytoskeleton-associated protein. (400 aa)
LOC102744262Heparanase-like. (166 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
MAL2Protein MAL2. (176 aa)
LOC102748609Sodium-dependent dopamine transporter-like. (364 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
PRKCDBPProtein kinase C delta-binding protein. (135 aa)
MALMyelin and lymphocyte protein. (197 aa)
GPM6BNeuronal membrane glycoprotein M6-b. (153 aa)
AQP1Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
CDHR2Cadherin-related family member 2. (1308 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
LOC102732425Myelin-associated glycoprotein-like. (382 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (496 aa)
LOC1027488165-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
LOC102747249Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (271 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC102727281Annexin. (187 aa)
KCNE3Potassium voltage-gated channel subfamily E member 3. (99 aa)
GPR56G-protein coupled receptor 56 isoform X3; Belongs to the G-protein coupled receptor 2 family. (687 aa)
GPC1Glypican-1-like; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
MLC1Membrane protein MLC1. (373 aa)
PTRFPolymerase I and transcript release factor isoform X1. (390 aa)
NEU2Sialidase-2-like. (379 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102740078Ragulator complex protein LAMTOR1-like. (98 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
PPAP2CLipid phosphate phosphohydrolase 2-like. (288 aa)
LOC102740770Tripeptidyl-peptidase 1-like. (572 aa)
CAPN8LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
LOC102727300Battenin-like. (109 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: medium (42%) [HD]