(70 nodes) Regulation of fat cell differentiation network (Leptonychotes weddellii)

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second shell of interactors

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Predicted Interactions

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Your Input:
	LGALS12	Galectin. (314 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B. (1155 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	MMP11	Stromelysin-3. (489 aa)
	SFRP1	Secreted frizzled-related protein 1. (303 aa)
	CDS1	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	YAP1	Yorkie homolog. (326 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	LOC102741543	Zinc finger protein ZFPM2-like. (827 aa)
	LOC102748816	5-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
	TPH1	Tryptophan 5-hydroxylase 1. (444 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	DKKL1	Dickkopf-like protein 1 isoform X3. (237 aa)
	LOC102744093	WW domain-containing transcription regulator protein 1-like. (286 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	LOC102729711	Protein FAM57B-like. (186 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
	FOXO1	Forkhead box protein O1-like. (418 aa)
	LOC102735151	Bone morphogenetic protein 7-like. (139 aa)
	C1QL4	Complement C1q-like protein 4. (238 aa)
	LOC102745331	Transcription initiation factor TFIID subunit 8-like. (269 aa)
	FRZB	Secreted frizzled-related protein 3-like. (306 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	LOC102750518	Tribbles homolog 3-like. (215 aa)
	ADIG	LOW QUALITY PROTEIN: adipogenin. (109 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	MEDAG	Mesenteric estrogen-dependent adipogenesis protein. (303 aa)
	ALOX5	Arachidonate 5-lipoxygenase isoform X1. (674 aa)
	ZNF385A	Zinc finger protein 385A isoform X1. (386 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	VSTM2A	V-set and transmembrane domain-containing protein 2A. (236 aa)
	STK3	Serine/threonine-protein kinase 3 isoform X1. (491 aa)
	RARRES2	Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
	SAV1	Protein salvador homolog 1. (384 aa)
	CEBPB	CCAAT/enhancer-binding protein. (345 aa)
	NAPEPLD	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (394 aa)
	WIF1	Wnt inhibitory factor 1. (379 aa)
	AXIN1	Axin-1 isoform X1. (867 aa)
	ASXL2	Putative Polycomb group protein ASXL2. (1452 aa)
	TRIO	Triple functional domain protein. (747 aa)
	WWTR1	WW domain-containing transcription regulator protein 1. (144 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
	LOC102735764	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (185 aa)
	MEX3C	RNA-binding E3 ubiquitin-protein ligase MEX3C. (465 aa)
	STK4	Serine/threonine-protein kinase 4. (487 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
	FERMT2	Fermitin family homolog 2 isoform X1. (687 aa)
	DLK2	Protein delta homolog 2 isoform X1. (383 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (441 aa)
	TFE3	Transcription factor E3 isoform X1. (571 aa)
	GPS2	G protein pathway suppressor 2 isoform X1. (327 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	ZFP36L1	Zinc finger protein 36, C3H1 type-like 1 isoform X1. (338 aa)
	CCDC85B	Coiled-coil domain-containing protein 85B. (202 aa)
	LOC102736999	Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
	ADIRF	Adipogenesis regulatory factor. (75 aa)
	WDFY2	WD repeat and FYVE domain-containing protein 2-like. (389 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	FFAR4	Free fatty acid receptor 4. (254 aa)
	LOC102730779	Coiled-coil domain-containing protein 71L-like. (112 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (742 aa)
	ZFP36L2	Zinc finger protein 36, C3H1 type-like 2-like. (491 aa)
	BMP7	Bone morphogenetic protein 7-like. (312 aa)
	ZFP36	Tristetraprolin. (325 aa)
	FLCN	Folliculin. (579 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIG	MEDAG	A0A2U3Z8U4	A0A2U3X976	LOW QUALITY PROTEIN: adipogenin.	Mesenteric estrogen-dependent adipogenesis protein.	0.476
AXIN1	FOXO1	A0A2U3XKZ5	A0A2U3Z4M9	Axin-1 isoform X1.	Forkhead box protein O1-like.	0.625
AXIN1	SFRP1	A0A2U3XKZ5	A0A2U3YST4	Axin-1 isoform X1.	Secreted frizzled-related protein 1.	0.416
AXIN1	SFRP2	A0A2U3XKZ5	A0A2U3X789	Axin-1 isoform X1.	Secreted frizzled-related protein 2.	0.436
AXIN1	WNT1	A0A2U3XKZ5	A0A2U3XCV6	Axin-1 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.703
BMP2	BMP7	A0A2U3Z3S1	A0A2U3YG58	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.592
BMP2	LOC102730318	A0A2U3Z3S1	A0A2U3Z2G6	Bone morphogenetic protein 2-like.	Mothers against decapentaplegic homolog.	0.621
BMP2	LOC102735151	A0A2U3Z3S1	A0A2U3Z6A5	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.582
BMP2	TGFB1	A0A2U3Z3S1	A0A2U3YVA3	Bone morphogenetic protein 2-like.	Transforming growth factor beta-1.	0.479
BMP7	BMP2	A0A2U3YG58	A0A2U3Z3S1	Bone morphogenetic protein 7-like.	Bone morphogenetic protein 2-like.	0.592
BMP7	LOC102730318	A0A2U3YG58	A0A2U3Z2G6	Bone morphogenetic protein 7-like.	Mothers against decapentaplegic homolog.	0.547
BMP7	LOC102735151	A0A2U3YG58	A0A2U3Z6A5	Bone morphogenetic protein 7-like.	Bone morphogenetic protein 7-like.	0.900
BMP7	TGFB1	A0A2U3YG58	A0A2U3YVA3	Bone morphogenetic protein 7-like.	Transforming growth factor beta-1.	0.552
CEBPB	CREB1	A0A2U3XKB7	A0A2U3XPQ5	CCAAT/enhancer-binding protein.	Cyclic AMP-responsive element-binding protein 1 isoform X1.	0.618
CEBPB	DDIT3	A0A2U3XKB7	A0A2U3Z433	CCAAT/enhancer-binding protein.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.764
CEBPB	FOXO1	A0A2U3XKB7	A0A2U3Z4M9	CCAAT/enhancer-binding protein.	Forkhead box protein O1-like.	0.723
CEBPB	GATA3	A0A2U3XKB7	A0A2U3YCA3	CCAAT/enhancer-binding protein.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.418
CEBPB	LEP	A0A2U3XKB7	A0A2U3YW34	CCAAT/enhancer-binding protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.535
CEBPB	LOC102730318	A0A2U3XKB7	A0A2U3Z2G6	CCAAT/enhancer-binding protein.	Mothers against decapentaplegic homolog.	0.432
CEBPB	LOC102750518	A0A2U3XKB7	A0A2U3Z826	CCAAT/enhancer-binding protein.	Tribbles homolog 3-like.	0.487