STRINGSTRING
LEF1 LEF1 IL7 IL7 SOX12 SOX12 NCKAP1L NCKAP1L FOXO3 FOXO3 PRKCZ PRKCZ ZAP70 ZAP70 IL10 IL10 ZMIZ1 ZMIZ1 SASH3 SASH3 ZBTB16 ZBTB16 CD83 CD83 LOC102738400 LOC102738400 BCL6 BCL6 NLRP12 NLRP12 IL2 IL2 MYB MYB STAT5B STAT5B ZBTB1 ZBTB1 GAS6 GAS6 TOX TOX IFNG IFNG LOC102736999 LOC102736999 EGR3 EGR3 IL23A IL23A CD74 CD74 GATA3 GATA3 CBFB CBFB RASGRP1 RASGRP1 LOC102743741 LOC102743741 FOXP3 FOXP3 HLX HLX MMP14 MMP14 AXL AXL SOCS5 SOCS5 AMBRA1 AMBRA1 TNFSF9 TNFSF9 STAT5A STAT5A IL4I1 IL4I1 LOC102745948 LOC102745948 PCK1 PCK1 SHH SHH WNT10B WNT10B LOC102731864 LOC102731864
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
SOX12Transcription factor SOX. (314 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
FOXO3Forkhead box protein O3. (672 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
IL10Interleukin-10. (178 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (957 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
CD83CD83 antigen isoform X1. (199 aa)
LOC102738400Annexin. (345 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
MYBTranscriptional activator Myb isoform X1. (761 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
TOXThymocyte selection-associated high mobility group box protein TOX. (487 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
CBFBCore-binding factor subunit beta isoform X1. (187 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
LOC102743741Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
HLXH2.0-like homeobox protein. (415 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
AXLTyrosine-protein kinase receptor UFO. (887 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1-like. (299 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (177 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
IL4I1L-amino-acid oxidase. (386 aa)
LOC102745948CD27 antigen-like. (261 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
SHHSonic hedgehog protein-like. (286 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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