(16 nodes) Regulation of T-helper cell differentiation network (Leptonychotes weddellii)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC102726900	Mothers against decapentaplegic homolog 7-like. (178 aa)
	LOC102738400	Annexin. (345 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	NLRP12	NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	MYB	Transcriptional activator Myb isoform X1. (761 aa)
	IL23A	Interleukin-23 subunit alpha. (210 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (456 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	HLX	H2.0-like homeobox protein. (415 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
	LOC102741183	Roquin-1-like. (688 aa)
	LOXL3	Lysyl oxidase homolog 3-like isoform X1. (392 aa)
	LOC102729738	Lysyl oxidase homolog 3-like. (231 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	FOXP3	A0A2U3Y0T0	A0A2U3YH69	B-cell lymphoma 6 protein.	Forkhead box protein P3 isoform X1.	0.786
BCL6	GATA3	A0A2U3Y0T0	A0A2U3YCA3	B-cell lymphoma 6 protein.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.582
BCL6	IL2	A0A2U3Y0T0	A0A2U3Y3E4	B-cell lymphoma 6 protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.525
BCL6	TBX21	A0A2U3Y0T0	A0A2U3YMK5	B-cell lymphoma 6 protein.	T-box transcription factor TBX21.	0.596
FOXP3	BCL6	A0A2U3YH69	A0A2U3Y0T0	Forkhead box protein P3 isoform X1.	B-cell lymphoma 6 protein.	0.786
FOXP3	GATA3	A0A2U3YH69	A0A2U3YCA3	Forkhead box protein P3 isoform X1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.793
FOXP3	IL2	A0A2U3YH69	A0A2U3Y3E4	Forkhead box protein P3 isoform X1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.908
FOXP3	TBX21	A0A2U3YH69	A0A2U3YMK5	Forkhead box protein P3 isoform X1.	T-box transcription factor TBX21.	0.609
GATA3	BCL6	A0A2U3YCA3	A0A2U3Y0T0	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	B-cell lymphoma 6 protein.	0.582
GATA3	FOXP3	A0A2U3YCA3	A0A2U3YH69	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Forkhead box protein P3 isoform X1.	0.793
GATA3	IL2	A0A2U3YCA3	A0A2U3Y3E4	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.591
GATA3	MYB	A0A2U3YCA3	A0A2U3Y3F7	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Transcriptional activator Myb isoform X1.	0.475
GATA3	TBX21	A0A2U3YCA3	A0A2U3YMK5	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	T-box transcription factor TBX21.	0.952
IL2	BCL6	A0A2U3Y3E4	A0A2U3Y0T0	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	B-cell lymphoma 6 protein.	0.525
IL2	FOXP3	A0A2U3Y3E4	A0A2U3YH69	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Forkhead box protein P3 isoform X1.	0.908
IL2	GATA3	A0A2U3Y3E4	A0A2U3YCA3	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.591
IL2	IL23A	A0A2U3Y3E4	A0A2U3YBV0	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin-23 subunit alpha.	0.809
IL2	TBX21	A0A2U3Y3E4	A0A2U3YMK5	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	T-box transcription factor TBX21.	0.455
IL23A	IL2	A0A2U3YBV0	A0A2U3Y3E4	Interleukin-23 subunit alpha.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.809
LOC102729738	LOXL3	A0A2U3XXJ3	A0A2U3XVA6	Lysyl oxidase homolog 3-like.	Lysyl oxidase homolog 3-like isoform X1.	0.900