STRINGSTRING
ZBTB46 ZBTB46 CASP8 CASP8 RB1 RB1 TRIB1 TRIB1 FADD FADD HSF1 HSF1 CSF1 CSF1 PTPN2 PTPN2 TGFB1 TGFB1 IL34 IL34 C1QC C1QC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZBTB46Zinc finger and BTB domain-containing protein 46. (318 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
RB1Retinoblastoma-associated protein. (846 aa)
TRIB1Tribbles homolog 1. (292 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
HSF1Heat shock factor protein 1. (527 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
IL34Interleukin-34. (236 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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