(37 nodes) Negative regulation of neuron differentiation network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	CNTF	Ciliary neurotrophic factor. (199 aa)
	GDF11	Growth/differentiation factor 11. (372 aa)
	PAX6	Paired box protein Pax-6. (221 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	HOXA2	Homeobox protein Hox-A2. (376 aa)
	LOC102729319	Insulin gene enhancer protein ISL-1-like. (349 aa)
	DLX1	Homeobox protein DLX-1 isoform X1. (255 aa)
	IRX3	Iroquois-class homeodomain protein IRX-3. (538 aa)
	DIXDC1	Dixin isoform X1. (683 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E transporter isoform X1. (987 aa)
	ISL2	LOW QUALITY PROTEIN: insulin gene enhancer protein ISL-2. (363 aa)
	TLX3	T-cell leukemia homeobox protein 3. (291 aa)
	PTCHD2	Patched domain-containing protein 2. (1393 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	CNTN2	Contactin-2. (903 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	SOX8	Transcription factor SOX-8. (412 aa)
	GPR37L1	Prosaposin receptor GPR37L1. (477 aa)
	DLX2	Homeobox protein DLX-2. (330 aa)
	POU4F2	POU domain protein. (408 aa)
	PHOX2B	Paired mesoderm homeobox protein 2B. (285 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	LOC102741508	Uncharacterized protein C3orf17 homolog. (562 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	LOC102726827	Eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	FEZF2	Fez family zinc finger protein 2. (464 aa)
	LOC102727345	Transcription factor SOX-9-like. (282 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein. (328 aa)
	HES3	Transcription factor HES-3. (178 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
	LOC102732425	Myelin-associated glycoprotein-like. (382 aa)
	CTDSP1	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2. (261 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2-like. (337 aa)
	LOC102750316	Hairy/enhancer-of-split related with YRPW motif protein 1-like isoform X2. (304 aa)
	LOC102731243	Zinc fingers and homeoboxes protein 2-like. (838 aa)
	LOC102731348	CDK5 regulatory subunit-associated protein 2-like. (233 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTN2	JAG1	A0A2U3Y064	A0A2U3XZY3	Contactin-2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.414
DLL1	DLX2	A0A2U3YLU9	A0A2U3Y9S8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Homeobox protein DLX-2.	0.411
DLL1	HEY2	A0A2U3YLU9	A0A2U3Z1Z4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 2-like.	0.411
DLL1	HEYL	A0A2U3YLU9	A0A2U3YQC3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.411
DLL1	JAG1	A0A2U3YLU9	A0A2U3XZY3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.490
DLL1	LOC102750316	A0A2U3YLU9	A0A2U3Z3H3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1-like isoform X2.	0.411
DLX1	DLX2	A0A2U3XK47	A0A2U3Y9S8	Homeobox protein DLX-1 isoform X1.	Homeobox protein DLX-2.	0.831
DLX1	FEZF2	A0A2U3XK47	A0A2U3YMR3	Homeobox protein DLX-1 isoform X1.	Fez family zinc finger protein 2.	0.444
DLX2	DLL1	A0A2U3Y9S8	A0A2U3YLU9	Homeobox protein DLX-2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.411
DLX2	DLX1	A0A2U3Y9S8	A0A2U3XK47	Homeobox protein DLX-2.	Homeobox protein DLX-1 isoform X1.	0.831
DLX2	FEZF2	A0A2U3Y9S8	A0A2U3YMR3	Homeobox protein DLX-2.	Fez family zinc finger protein 2.	0.642
DLX2	PAX6	A0A2U3Y9S8	A0A2U3XCB4	Homeobox protein DLX-2.	Paired box protein Pax-6.	0.457
EIF4ENIF1	LOC102726827	A0A2U3XQ25	A0A2U3YMQ7	Eukaryotic translation initiation factor 4E transporter isoform X1.	Eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family.	0.908
FEZF2	DLX1	A0A2U3YMR3	A0A2U3XK47	Fez family zinc finger protein 2.	Homeobox protein DLX-1 isoform X1.	0.444
FEZF2	DLX2	A0A2U3YMR3	A0A2U3Y9S8	Fez family zinc finger protein 2.	Homeobox protein DLX-2.	0.642
FEZF2	PAX6	A0A2U3YMR3	A0A2U3XCB4	Fez family zinc finger protein 2.	Paired box protein Pax-6.	0.604
HEY2	DLL1	A0A2U3Z1Z4	A0A2U3YLU9	Hairy/enhancer-of-split related with YRPW motif protein 2-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.411
HEY2	JAG1	A0A2U3Z1Z4	A0A2U3XZY3	Hairy/enhancer-of-split related with YRPW motif protein 2-like.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.489
HEYL	DLL1	A0A2U3YQC3	A0A2U3YLU9	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.411
HEYL	JAG1	A0A2U3YQC3	A0A2U3XZY3	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.489