STRINGSTRING
LOC102740025 LOC102740025 LOC102745703 LOC102745703 SFRP2 SFRP2 LOC102726446 LOC102726446 ALOX5 ALOX5 ECM1 ECM1 ITGA5 ITGA5 BMPER BMPER GLUL GLUL NR2E1 NR2E1 APOH APOH IL8 IL8 GREM1 GREM1 SULF1 SULF1 MAPK7 MAPK7 PROK1 PROK1 HOXA5 HOXA5 GATA6 GATA6 LOC102734862 LOC102734862 SERPINE1 SERPINE1 CCL24 CCL24 HSPB1 HSPB1 LOC102729529 LOC102729529 IL10 IL10 PDCL3 PDCL3 SYNJ2BP SYNJ2BP EMP2 EMP2 EFNA1 EFNA1 LOC102745146 LOC102745146 GAB1 GAB1 AGGF1 AGGF1 GADD45A GADD45A BTG1 BTG1 HIPK2 HIPK2 FKBPL FKBPL C5 C5 LOC102732879 LOC102732879 LOC102730452 LOC102730452 LOC102750159 LOC102750159 TEK TEK FOXO4 FOXO4 FASLG FASLG ITGB1 ITGB1 E2F2 E2F2 HTATIP2 HTATIP2 FOXJ2 FOXJ2 TGFB2 TGFB2 DDAH2 DDAH2 TNF TNF HIF1A HIF1A LOC102745161 LOC102745161 SIRT6 SIRT6 VASH1 VASH1 MECP2 MECP2 PAK4 PAK4 VEGFC VEGFC LOC102734979 LOC102734979 ETS1 ETS1 CHRNA7 CHRNA7 LOC102743414 LOC102743414 PML PML ANGPT2 ANGPT2 LECT1 LECT1 GPR124 GPR124 SP1 SP1 ISM1 ISM1 VASH2 VASH2 THBS1 THBS1 ATF2 ATF2 PDCD6 PDCD6 SARS SARS HSPB6 HSPB6 HGS HGS EMILIN1 EMILIN1 PDE3B PDE3B ACVRL1 ACVRL1 TNMD TNMD GTF2I GTF2I CXCL10 CXCL10 SMAD1 SMAD1 APOA1BP APOA1BP JUP JUP RRAS RRAS DLL1 DLL1 RHOJ RHOJ SEMA6A SEMA6A FGF18 FGF18 ENPP2 ENPP2 LRG1 LRG1 LOC102736811 LOC102736811 NODAL NODAL PGF PGF CTSH CTSH ANGPT4 ANGPT4 LOC102737831 LOC102737831 VEGFB VEGFB KIAA1024 KIAA1024 SFRP1 SFRP1 LOC102735329 LOC102735329 WISP3 WISP3 FUT1 FUT1 LEP LEP EPHA1 EPHA1 CREB3L1 CREB3L1 AQP1 AQP1 S100A1 S100A1 ECSCR ECSCR IL17F IL17F ABL1 ABL1 LOC102749531 LOC102749531 LOC102743045 LOC102743045 EMC10 EMC10 LOC102727675 LOC102727675 CXCR3 CXCR3 KIAA1462 KIAA1462 LOC102740157 LOC102740157 LOC102741947 LOC102741947 SASH1 SASH1 LOC102740057 LOC102740057 NF1 NF1 FGF2 FGF2 LOC102736544 LOC102736544 RAMP2 RAMP2 STAT3 STAT3 LOC102744822 LOC102744822 TIE1 TIE1 JMJD8 JMJD8 LOC102736146 LOC102736146 LOC102737563 LOC102737563 LOC102732559 LOC102732559 LOC102749847 LOC102749847 SEMA4A SEMA4A CHI3L1 CHI3L1 LOC102730129 LOC102730129 LOC102750030 LOC102750030 CLDN5 CLDN5 LOC102743174 LOC102743174
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102740025Protein sprouty homolog 2-like isoform X1. (315 aa)
LOC102745703Pyruvate kinase; Belongs to the pyruvate kinase family. (610 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
ECM1LOW QUALITY PROTEIN: extracellular matrix protein 1. (550 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
BMPERBMP-binding endothelial regulator protein-like. (446 aa)
GLULGlutamine synthetase. (413 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
GREM1Gremlin. (184 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PROK1Prokineticin-1. (105 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
GATA6Transcription factor GATA-6. (287 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
CCL24c-C motif chemokine 24. (119 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
LOC102729529Protein argonaute-2-like; Belongs to the argonaute family. (787 aa)
IL10Interleukin-10. (178 aa)
PDCL3Phosducin-like protein 3. (239 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1-like. (716 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
BTG1Protein BTG1. (171 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
FKBPLFK506-binding protein-like. (349 aa)
C5Complement C5. (1391 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
LOC102730452semaphorin-4A-like; Belongs to the semaphorin family. (436 aa)
LOC102750159Junction plakoglobin-like. (503 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
FOXO4Forkhead box protein O4 isoform X1. (506 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
E2F2Transcription factor E2F2. (440 aa)
HTATIP2Oxidoreductase HTATIP2. (204 aa)
FOXJ2Forkhead box protein J2. (572 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
DDAH2N(G),N(G)-dimethylarginine dimethylaminohydrolase 2. (285 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
VASH1Vasohibin-1. (363 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (499 aa)
PAK4Non-specific serine/threonine protein kinase. (441 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
LOC102734979Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family. (543 aa)
ETS1Protein C-ets-1-like isoform X1. (441 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7-like isoform X2. (499 aa)
LOC102743414Thrombospondin-2-like. (463 aa)
PMLProtein PML. (880 aa)
ANGPT2Angiopoietin-2 isoform X1. (495 aa)
LECT1Leukocyte cell-derived chemotaxin 1. (360 aa)
GPR124G-protein coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1332 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
ISM1Isthmin-1. (464 aa)
VASH2Vasohibin-2 isoform X1. (355 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
SARSserine--tRNA ligase, cytoplasmic. (265 aa)
HSPB6Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family. (156 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (781 aa)
EMILIN1EMILIN-1-like. (1013 aa)
PDE3BPhosphodiesterase. (1180 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TNMDTenomodulin. (217 aa)
GTF2IGeneral transcription factor II-I. (992 aa)
CXCL10C-X-C motif chemokine. (98 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
APOA1BPNAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (248 aa)
JUPJunction plakoglobin. (307 aa)
RRASRas-related protein R-Ras. (218 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
RHOJRho-related GTP-binding protein RhoJ. (214 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
FGF18Fibroblast growth factor 18. (116 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (915 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (354 aa)
LOC102736811UPF0556 protein C19orf10 homolog. (173 aa)
NODALNodal homolog. (348 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
ANGPT4Angiopoietin-4. (498 aa)
LOC102737831Serine/threonine-protein kinase D2-like. (246 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
KIAA1024UPF0258 protein KIAA1024 homolog. (832 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
WISP3WNT1-inducible-signaling pathway protein 3. (354 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (408 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
EPHA1Ephrin type-A receptor 1. (976 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
AQP1Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
ECSCREndothelial cell-specific chemotaxis regulator. (213 aa)
IL17Finterleukin-17F. (157 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (262 aa)
LOC102727675Decorin; May affect the rate of fibrils formation. (360 aa)
CXCR3c-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
KIAA1462Junctional protein associated with coronary artery disease-like. (1360 aa)
LOC102740157Cadherin-5-like; Cadherins are calcium-dependent cell adhesion proteins. (464 aa)
LOC102741947Tenomodulin-like. (164 aa)
SASH1SAM and SH3 domain-containing protein 1-like. (1070 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
NF1Neurofibromin-like. (1269 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102736544Thrombospondin-4-like. (685 aa)
RAMP2Receptor activity-modifying protein 2. (118 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (1015 aa)
JMJD8jmjC domain-containing protein 8. (296 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102737563Complement C5-like. (186 aa)
LOC102732559Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
SEMA4Asemaphorin-4A-like. (350 aa)
CHI3L1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (384 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (309 aa)
LOC102743174Oxidoreductase HTATIP2-like. (65 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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