(24 nodes) Regulation of activated T cell proliferation network (Leptonychotes weddellii)

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Your Input:
	HHLA2	LOW QUALITY PROTEIN: HERV-H LTR-associating 2. (282 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (242 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (394 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	LOC102741183	Roquin-1-like. (688 aa)
	AGER	Advanced glycosylation end product-specific receptor. (397 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	STAT5B	Signal transducer and activator of transcription 5B. (508 aa)
	IL23A	Interleukin-23 subunit alpha. (210 aa)
	LOC102739213	High mobility group protein B1-like. (214 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
	SLAMF1	Signaling lymphocytic activation molecule. (312 aa)
	PRNP	Major prion protein; Belongs to the prion family. (257 aa)
	STAT5A	Signal transducer and activator of transcription 5A. (464 aa)
	LOC102731864	Signal transducer and activator of transcription 5B-like. (353 aa)
	IGF2	Insulin-like growth factor II. (138 aa)
	LOC102745732	Leucine-rich repeat-containing protein 1-like. (92 aa)
	TNFSF9	Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (177 aa)
	CRTAM	Cytotoxic and regulatory T-cell molecule. (366 aa)
	LRRC32	Leucine-rich repeat-containing protein 32. (663 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	LOC102739213	A0A2U3XY32	A0A2U3YCB6	Advanced glycosylation end product-specific receptor.	High mobility group protein B1-like.	0.720
HHLA2	TNFSF9	A0A2U3Z8Y2	A0A2U3YZM1	LOW QUALITY PROTEIN: HERV-H LTR-associating 2.	Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family.	0.507
IDO1	IL2	A0A2U3XKN7	A0A2U3Y3E4	Indoleamine 2,3-dioxygenase 1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.493
IL12B	IL2	A0A2U3YD60	A0A2U3Y3E4	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.841
IL12B	IL23A	A0A2U3YD60	A0A2U3YBV0	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	Interleukin-23 subunit alpha.	0.998
IL18	IL2	A0A2U3XPG8	A0A2U3Y3E4	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.661
IL18	LOC102739213	A0A2U3XPG8	A0A2U3YCB6	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	High mobility group protein B1-like.	0.561
IL18	PYCARD	A0A2U3XPG8	A0A2U3XEL1	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Apoptosis-associated speck-like protein containing a CARD isoform X1.	0.975
IL2	IDO1	A0A2U3Y3E4	A0A2U3XKN7	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Indoleamine 2,3-dioxygenase 1.	0.493
IL2	IL12B	A0A2U3Y3E4	A0A2U3YD60	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.841
IL2	IL18	A0A2U3Y3E4	A0A2U3XPG8	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.661
IL2	IL23A	A0A2U3Y3E4	A0A2U3YBV0	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin-23 subunit alpha.	0.809
IL2	LOC102731864	A0A2U3Y3E4	A0A2U3Z7Y1	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Signal transducer and activator of transcription 5B-like.	0.510
IL2	STAT5A	A0A2U3Y3E4	A0A2U3Z446	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Signal transducer and activator of transcription 5A.	0.739
IL2	STAT5B	A0A2U3Y3E4	A0A2U3Y4J7	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Signal transducer and activator of transcription 5B.	0.510
IL23A	IL12B	A0A2U3YBV0	A0A2U3YD60	Interleukin-23 subunit alpha.	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.	0.998
IL23A	IL2	A0A2U3YBV0	A0A2U3Y3E4	Interleukin-23 subunit alpha.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.809
LOC102731864	IL2	A0A2U3Z7Y1	A0A2U3Y3E4	Signal transducer and activator of transcription 5B-like.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.510
LOC102731864	STAT5A	A0A2U3Z7Y1	A0A2U3Z446	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 5A.	0.948
LOC102731864	STAT5B	A0A2U3Z7Y1	A0A2U3Y4J7	Signal transducer and activator of transcription 5B-like.	Signal transducer and activator of transcription 5B.	0.947