(19 nodes) Vascular endothelial growth factor receptor signaling pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102735329	Vascular endothelial growth factor receptor 1-like. (351 aa)
	LOC102743045	Disabled homolog 2-interacting protein-like. (326 aa)
	LOC102740057	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
	LOC102730108	Neuropilin-1-like. (465 aa)
	LOC102726881	Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
	LOC102737672	C-type lectin domain family 14 member A-like. (489 aa)
	LOC102730129	Uncharacterized protein LOC102730129. (471 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
	HSPB1	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
	LOC102732879	Disabled homolog 2-interacting protein-like. (454 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	PDCD6	Programmed cell death protein 6 isoform X1. (189 aa)
	FGF18	Fibroblast growth factor 18. (116 aa)
	PGF	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	LOC102737831	Serine/threonine-protein kinase D2-like. (246 aa)
	VEGFB	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF10	FGF18	A0A2U3XE64	A0A2U3YP56	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18.	0.504
FGF10	LOC102730129	A0A2U3XE64	A0A2U3Z8I1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein LOC102730129.	0.442
FGF10	LOC102735329	A0A2U3XE64	A0A2U3YU32	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor receptor 1-like.	0.860
FGF10	LOC102740057	A0A2U3XE64	A0A2U3Z228	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.442
FGF10	PGF	A0A2U3XE64	A0A2U3YQ46	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family.	0.491
FGF10	VEGFC	A0A2U3XE64	A0A2U3Y8G6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.426
FGF18	FGF10	A0A2U3YP56	A0A2U3XE64	Fibroblast growth factor 18.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.504
FGF18	FGF9	A0A2U3YP56	A0A2U3X8U2	Fibroblast growth factor 18.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.482
FGF18	LOC102730129	A0A2U3YP56	A0A2U3Z8I1	Fibroblast growth factor 18.	Uncharacterized protein LOC102730129.	0.463
FGF18	LOC102735329	A0A2U3YP56	A0A2U3YU32	Fibroblast growth factor 18.	Vascular endothelial growth factor receptor 1-like.	0.866
FGF18	LOC102740057	A0A2U3YP56	A0A2U3Z228	Fibroblast growth factor 18.	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.463
FGF18	PGF	A0A2U3YP56	A0A2U3YQ46	Fibroblast growth factor 18.	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family.	0.491
FGF18	VEGFC	A0A2U3YP56	A0A2U3Y8G6	Fibroblast growth factor 18.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.414
FGF9	FGF18	A0A2U3X8U2	A0A2U3YP56	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18.	0.482
FGF9	LOC102730108	A0A2U3X8U2	A0A2U3Z2Y2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Neuropilin-1-like.	0.405
FGF9	LOC102730129	A0A2U3X8U2	A0A2U3Z8I1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein LOC102730129.	0.462
FGF9	LOC102735329	A0A2U3X8U2	A0A2U3YU32	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor receptor 1-like.	0.862
FGF9	LOC102740057	A0A2U3X8U2	A0A2U3Z228	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.462
FGF9	PGF	A0A2U3X8U2	A0A2U3YQ46	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family.	0.491
FGF9	VEGFB	A0A2U3X8U2	A0A2U3YRT5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family.	0.476