(15 nodes) Inositol phosphate-mediated signaling network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	NMUR1	neuromedin-U receptor 1; Belongs to the G-protein coupled receptor 1 family. (429 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
	TBC1D10C	Carabin-like. (446 aa)
	INPP5A	Type I inositol 1,4,5-trisphosphate 5-phosphatase. (364 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
	LOC102725943	Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
	LOC102748949	Calcipressin-1-like. (140 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
	NFAT5	Nuclear factor of activated T-cells 5 isoform X1. (1545 aa)
	PPP3R1	Calcineurin subunit B type 1 isoform X1. (170 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
	NMUR2	neuromedin-U receptor 2; Belongs to the G-protein coupled receptor 1 family. (402 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ITPR1	ITPR2	A0A2U3YEA6	A0A2U3Y2Z3	Inositol 1,4,5-trisphosphate receptor type 1.	Inositol 1,4,5-trisphosphate receptor type 2-like.	0.837
ITPR1	ITPR3	A0A2U3YEA6	A0A2U3YJ50	Inositol 1,4,5-trisphosphate receptor type 1.	Inositol 1,4,5-trisphosphate receptor type 3.	0.873
ITPR2	ITPR1	A0A2U3Y2Z3	A0A2U3YEA6	Inositol 1,4,5-trisphosphate receptor type 2-like.	Inositol 1,4,5-trisphosphate receptor type 1.	0.837
ITPR3	ITPR1	A0A2U3YJ50	A0A2U3YEA6	Inositol 1,4,5-trisphosphate receptor type 3.	Inositol 1,4,5-trisphosphate receptor type 1.	0.873
LOC102725943	LOC102748949	A0A2U3YQY8	A0A2U3Z6U4	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Calcipressin-1-like.	0.493
LOC102725943	MAPK7	A0A2U3YQY8	A0A2U3XK88	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.494
LOC102725943	NFATC1	A0A2U3YQY8	A0A2U3YQR5	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Nuclear factor of activated T-cells, cytoplasmic 1.	0.923
LOC102725943	NFATC3	A0A2U3YQY8	A0A2U3XF88	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1.	0.915
LOC102725943	PPP3R1	A0A2U3YQY8	A0A2U3XF20	Nuclear factor of activated T-cells, cytoplasmic 2-like.	Calcineurin subunit B type 1 isoform X1.	0.879
LOC102748949	LOC102725943	A0A2U3Z6U4	A0A2U3YQY8	Calcipressin-1-like.	Nuclear factor of activated T-cells, cytoplasmic 2-like.	0.493
LOC102748949	NFATC3	A0A2U3Z6U4	A0A2U3XF88	Calcipressin-1-like.	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1.	0.482
LOC102748949	PPP3R1	A0A2U3Z6U4	A0A2U3XF20	Calcipressin-1-like.	Calcineurin subunit B type 1 isoform X1.	0.762
MAPK7	LOC102725943	A0A2U3XK88	A0A2U3YQY8	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Nuclear factor of activated T-cells, cytoplasmic 2-like.	0.494
MAPK7	NFATC1	A0A2U3XK88	A0A2U3YQR5	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Nuclear factor of activated T-cells, cytoplasmic 1.	0.507
MAPK7	NFATC3	A0A2U3XK88	A0A2U3XF88	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1.	0.516
MAPK7	PPP3R1	A0A2U3XK88	A0A2U3XF20	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Calcineurin subunit B type 1 isoform X1.	0.407
NFATC1	LOC102725943	A0A2U3YQR5	A0A2U3YQY8	Nuclear factor of activated T-cells, cytoplasmic 1.	Nuclear factor of activated T-cells, cytoplasmic 2-like.	0.923
NFATC1	MAPK7	A0A2U3YQR5	A0A2U3XK88	Nuclear factor of activated T-cells, cytoplasmic 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.507
NFATC1	NFATC3	A0A2U3YQR5	A0A2U3XF88	Nuclear factor of activated T-cells, cytoplasmic 1.	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1.	0.907
NFATC1	PPP3R1	A0A2U3YQR5	A0A2U3XF20	Nuclear factor of activated T-cells, cytoplasmic 1.	Calcineurin subunit B type 1 isoform X1.	0.977