(54 nodes) Regulation of fibroblast proliferation network (Leptonychotes weddellii)

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second shell of interactors

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Predicted Interactions

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Your Input:
	EREG	Proepiregulin. (292 aa)
	LOC102731342	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	LOC102737670	Cyclin-dependent kinase 6-like. (322 aa)
	NUPR1	Nuclear protein 1 isoform X1. (82 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (852 aa)
	DDR2	Discoidin domain-containing receptor 2-like. (367 aa)
	PAWR	PRKC apoptosis WT1 regulator protein. (290 aa)
	ZMIZ1	Zinc finger MIZ domain-containing protein 1. (957 aa)
	B4GALT7	Beta-1,4-galactosyltransferase 7-like. (327 aa)
	LOC102732879	Disabled homolog 2-interacting protein-like. (454 aa)
	FBXO4	F-box only protein 4. (387 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	FBRS	Probable fibrosin-1. (357 aa)
	CTC1	CST complex subunit CTC1. (1218 aa)
	GAS6	Growth arrest-specific protein 6. (646 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	NDUFS4	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. (175 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (335 aa)
	CD248	Endosialin. (774 aa)
	LIG4	DNA ligase. (911 aa)
	PML	Protein PML. (880 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	WAPAL	Wings apart-like protein homolog. (1154 aa)
	INCA1	Protein INCA1. (251 aa)
	PLA2G1B	Phospholipase A(2). (146 aa)
	MORC3	MORC family CW-type zinc finger protein 3. (900 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B. (1155 aa)
	LOC102749901	Gamma-interferon-inducible-lysosomal thiol reductase-like. (252 aa)
	SFRP1	Secreted frizzled-related protein 1. (303 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	MED31	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	TRIM32	E3 ubiquitin-protein ligase TRIM32-like isoform X1. (655 aa)
	LOC102734131	Fos-related antigen 2-like. (241 aa)
	AQP1	Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	ABL1	Tyrosine-protein kinase ABL1-like. (312 aa)
	LOC102743045	Disabled homolog 2-interacting protein-like. (326 aa)
	NF1	Neurofibromin-like. (1269 aa)
	LOC102750901	Mediator of RNA polymerase II transcription subunit 25-like. (746 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
	EMD	Emerin. (260 aa)
	C1QL4	Complement C1q-like protein 4. (238 aa)
	LOC102741471	Parafibromin-like. (141 aa)
	PEX2	Peroxisome biogenesis factor 2 isoform X1. (305 aa)
	LOC102735317	Dachshund homolog 1-like. (666 aa)
	CD300A	CMRF35-like molecule 8. (309 aa)
	CDC73	Parafibromin. (418 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	DHX9	ATP-dependent RNA helicase A. (1276 aa)
	PDGFC	Platelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	BMI1	Polycomb complex protein BMI-1 isoform X1. (326 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDKN1A	A0A2U3YZ15	A0A2U3Z5P5	Tyrosine-protein kinase ABL1-like.	Cyclin-dependent kinase inhibitor 1 isoform X1.	0.585
ABL1	TP53	A0A2U3YZ15	A0A2U3Y5G3	Tyrosine-protein kinase ABL1-like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.503
BMI1	TP53	A0A2U3XEE7	A0A2U3Y5G3	Polycomb complex protein BMI-1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.644
CAV1	ITGB3	A0A2U3XCN0	A0A2U3XSL7	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.857
CD300A	GAS6	A0A2U3X9N2	A0A2U3Y4W6	CMRF35-like molecule 8.	Growth arrest-specific protein 6.	0.402
CDC73	LOC102741471	A0A2U3XAJ4	A0A2U3Z805	Parafibromin.	Parafibromin-like.	0.949
CDKN1A	ABL1	A0A2U3Z5P5	A0A2U3YZ15	Cyclin-dependent kinase inhibitor 1 isoform X1.	Tyrosine-protein kinase ABL1-like.	0.585
CDKN1A	JUN	A0A2U3Z5P5	A0A2U3Y748	Cyclin-dependent kinase inhibitor 1 isoform X1.	Transcription factor AP-1; Belongs to the bZIP family.	0.521
CDKN1A	LOC102737670	A0A2U3Z5P5	A0A2U3XML5	Cyclin-dependent kinase inhibitor 1 isoform X1.	Cyclin-dependent kinase 6-like.	0.996
CDKN1A	PDGFRA	A0A2U3Z5P5	A0A2U3YV07	Cyclin-dependent kinase inhibitor 1 isoform X1.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.429
CDKN1A	TP53	A0A2U3Z5P5	A0A2U3Y5G3	Cyclin-dependent kinase inhibitor 1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.993
EMD	ZMPSTE24	A0A2U3Z6Y5	A0A2U3Y1L9	Emerin.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.542
EREG	PDGFRA	A0A2U3XEH8	A0A2U3YV07	Proepiregulin.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.808
FBRS	LOC102737670	A0A2U3Y2Z9	A0A2U3XML5	Probable fibrosin-1.	Cyclin-dependent kinase 6-like.	0.403
FGF10	PDGFRA	A0A2U3XE64	A0A2U3YV07	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.913
GAS6	CD300A	A0A2U3Y4W6	A0A2U3X9N2	Growth arrest-specific protein 6.	CMRF35-like molecule 8.	0.402
ITGB3	CAV1	A0A2U3XSL7	A0A2U3XCN0	Integrin beta; Belongs to the integrin beta chain family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.857
JUN	CDKN1A	A0A2U3Y748	A0A2U3Z5P5	Transcription factor AP-1; Belongs to the bZIP family.	Cyclin-dependent kinase inhibitor 1 isoform X1.	0.521
JUN	LOC102734131	A0A2U3Y748	A0A2U3YV46	Transcription factor AP-1; Belongs to the bZIP family.	Fos-related antigen 2-like.	0.994
JUN	LOC102737670	A0A2U3Y748	A0A2U3XML5	Transcription factor AP-1; Belongs to the bZIP family.	Cyclin-dependent kinase 6-like.	0.487