STRINGSTRING
GPR149 GPR149 LGR4 LGR4 LOC102725945 LOC102725945 GAS2 GAS2 ID1 ID1 DNM1L DNM1L BHLHE41 BHLHE41 AANAT AANAT CIART CIART DHX9 DHX9 LOC102750498 LOC102750498 FOXO3 FOXO3 AHR AHR NR5A2 NR5A2 MAPK10 MAPK10 AFP AFP ATF4 ATF4 EP300 EP300 EZH2 EZH2 CRY1 CRY1 PTEN PTEN PRKAA1 PRKAA1 NFIL3 NFIL3 CREB1 CREB1 LOC102728212 LOC102728212 BMPR1B BMPR1B LOC102730550 LOC102730550 TNFAIP6 TNFAIP6 LOC102733670 LOC102733670 GPR157 GPR157 SUV39H2 SUV39H2 NRIP1 NRIP1 KLF10 KLF10 TYRO3 TYRO3 THRAP3 THRAP3 LOC102728321 LOC102728321 LOC102738400 LOC102738400 LOC102729647 LOC102729647 EGR1 EGR1 LOC102745977 LOC102745977 HTR7 HTR7 PER1 PER1 MAPK8 MAPK8 SUV39H1 SUV39H1 KCND1 KCND1 STAT5B STAT5B BTBD9 BTBD9 TP53 TP53 CARTPT CARTPT NTRK2 NTRK2 LOC102741496 LOC102741496 NDUFA9 NDUFA9 NR0B2 NR0B2 USP2 USP2 KDM5B KDM5B PROK2 PROK2 ROCK2 ROCK2 CSNK1D CSNK1D PML PML TIMELESS TIMELESS KCND3 KCND3 PRMT5 PRMT5 LOC102749081 LOC102749081 PPP1CB PPP1CB GPR176 GPR176 GSK3B GSK3B LOC102733902 LOC102733902 KCND2 KCND2 PSPC1 PSPC1 LOC102745380 LOC102745380 NHLH1 NHLH1 ATF5 ATF5 NHLH2 NHLH2 ID2 ID2 NR1D2 NR1D2 ENPP2 ENPP2 ARNTL ARNTL ZNF830 ZNF830 LOC102729383 LOC102729383 PPARGC1A PPARGC1A NR1D1 NR1D1 ASS1 ASS1 LOC102732116 LOC102732116 LOC102730998 LOC102730998 GNB2L1 GNB2L1 MTTP MTTP CREBBP CREBBP RAI1 RAI1 FZD4 FZD4 DYRK1A DYRK1A MYBBP1A MYBBP1A SGPL1 SGPL1 PDGFRA PDGFRA PRKCDBP PRKCDBP LOC102729992 LOC102729992 AXL AXL INHBA INHBA RBM4B RBM4B CSNK1E CSNK1E TP73 TP73 LOC102728272 LOC102728272 LOC102737749 LOC102737749 LOC102740250 LOC102740250 NTRK1 NTRK1 CCDC90B CCDC90B KDM8 KDM8 LOC102746542 LOC102746542 KDM2A KDM2A PPP1CA PPP1CA LOC102728894 LOC102728894 OGT OGT PPARA PPARA FBXW9 FBXW9 HNRNPU HNRNPU STAT5A STAT5A LOC102742564 LOC102742564 CRY2 CRY2 LOC102742767 LOC102742767 LOC102735556 LOC102735556 IMPDH2 IMPDH2 LOC102732257 LOC102732257 LOC102733867 LOC102733867 CDK5 CDK5 LOC102729222 LOC102729222 LOC102731864 LOC102731864 CLOCK CLOCK LHCGR LHCGR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR149Probable G-protein coupled receptor 149. (734 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
GAS2Growth arrest-specific protein 2 isoform X1. (313 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (376 aa)
AANATSerotonin N-acetyltransferase. (209 aa)
CIARTLOW QUALITY PROTEIN: uncharacterized protein C1orf51 homolog. (385 aa)
DHX9ATP-dependent RNA helicase A. (1276 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
FOXO3Forkhead box protein O3. (672 aa)
AHRAryl hydrocarbon receptor. (843 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2-like isoform X1. (541 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
AFPAlpha-fetoprotein. (609 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
EP300Histone acetyltransferase p300. (2425 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
CRY1Cryptochrome-1. (587 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
NFIL3Nuclear factor interleukin-3-regulated protein. (462 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LOC102728212UPF0524 protein C3orf70 homolog. (250 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC102730550Coiled-coil domain-containing protein 90B, mitochondrial-like. (175 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
LOC102733670Probable helicase senataxin-like. (227 aa)
GPR157LOW QUALITY PROTEIN: probable G-protein coupled receptor 157. (328 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
NRIP1Nuclear receptor-interacting protein 1 isoform X1. (1156 aa)
KLF10Krueppel-like factor 10 isoform X1. (480 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (845 aa)
THRAP3Thyroid hormone receptor-associated protein 3 isoform X2. (957 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
LOC102738400Annexin. (345 aa)
LOC102729647BTB/POZ domain-containing protein 9-like. (184 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
LOC102745977non-POU domain-containing octamer-binding protein-like. (115 aa)
HTR75-hydroxytryptamine receptor 7. (435 aa)
PER1Period circadian protein homolog 1. (1287 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
BTBD9BTB/POZ domain-containing protein 9-like. (391 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (116 aa)
NTRK2BDNF/NT-3 growth factors receptor-like. (420 aa)
LOC102741496BDNF/NT-3 growth factors receptor-like. (97 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (377 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (279 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
KDM5BLysine-specific demethylase 5B. (872 aa)
PROK2Prokineticin-2 isoform X2. (108 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
CSNK1DCasein kinase I isoform delta isoform X2. (399 aa)
PMLProtein PML. (880 aa)
TIMELESSProtein timeless homolog. (1212 aa)
KCND3Potassium voltage-gated channel subfamily D member 3. (283 aa)
PRMT5Protein arginine N-methyltransferase 5-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (467 aa)
LOC102749081Nuclear receptor corepressor 2-like. (252 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GPR176Probable G-protein coupled receptor 176 isoform X1. (510 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC102733902Paraspeckle component 1-like. (133 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (629 aa)
PSPC1Paraspeckle component 1. (391 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
NHLH1Helix-loop-helix protein 1. (133 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (280 aa)
NHLH2Helix-loop-helix protein 2. (135 aa)
ID2DNA-binding protein inhibitor ID-2 isoform X2. (134 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (576 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (915 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X5. (583 aa)
ZNF830Zinc finger protein 830. (371 aa)
LOC102729383Class E basic helix-loop-helix protein 40-like isoform X1. (412 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ASS1Argininosuccinate synthase. (294 aa)
LOC102732116Follicle-stimulating hormone receptor-like. (181 aa)
LOC102730998Protein arginine N-methyltransferase 5-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (138 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (894 aa)
CREBBPCREB-binding protein-like. (1411 aa)
RAI1Retinoic acid-induced protein 1. (1885 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A-like isoform X1. (762 aa)
MYBBP1AMyb-binding protein 1A isoform X1. (1332 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
PRKCDBPProtein kinase C delta-binding protein. (135 aa)
LOC102729992D site-binding protein-like. (175 aa)
AXLTyrosine-protein kinase receptor UFO. (887 aa)
INHBAInhibin beta A chain. (424 aa)
RBM4BRNA-binding protein 4B isoform X1. (359 aa)
CSNK1ECasein kinase I isoform epsilon isoform X2. (359 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
LOC102728272Neuronal PAS domain-containing protein 2-like. (395 aa)
LOC102737749Transcription factor RelB-like. (167 aa)
LOC102740250Melanoma-associated antigen D1-like isoform X2. (781 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
CCDC90BCoiled-coil domain-containing protein 90B, mitochondrial. (139 aa)
KDM8Lysine-specific demethylase 8. (414 aa)
LOC102746542Transient receptor potential cation channel subfamily M member 2-like. (677 aa)
KDM2ALysine-specific demethylase 2A. (349 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102728894Period circadian protein homolog 3-like. (155 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
CRY2Cryptochrome-2. (527 aa)
LOC102742767E3 ubiquitin-protein ligase HUWE1-like. (1184 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
LOC102732257Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (469 aa)
LOC102733867Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
LOC102729222Schwannomin-interacting protein 1-like. (146 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
CLOCKLOW QUALITY PROTEIN: clock circadian regulator. (846 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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