(18 nodes) Embryonic digestive tract development network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	IL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	NIPBL	Nipped-B protein. (2803 aa)
	RARRES2	Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
	FOXF2	Forkhead box protein F2. (263 aa)
	MSC	Musculin. (198 aa)
	RARB	Retinoic acid receptor beta. (172 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TCF21	Transcription factor 21. (179 aa)
	LOC102737096	Retinoic acid receptor beta-like. (262 aa)
	ALDH1A2	Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
	FOXF1	Forkhead box protein F1. (427 aa)
	HLX	H2.0-like homeobox protein. (415 aa)
	SALL1	Sal-like protein 1-like. (1314 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
	SHH	Sonic hedgehog protein-like. (286 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A2	TCF21	A0A2U3YKD4	A0A2U3Y9R6	Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family.	Transcription factor 21.	0.424
FGF10	IL8	A0A2U3XE64	A0A2U3XEG2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.451
FGF10	PDGFRA	A0A2U3XE64	A0A2U3YV07	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.913
FGF10	SHH	A0A2U3XE64	A0A2U3Z6V6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sonic hedgehog protein-like.	0.827
FGF10	TNF	A0A2U3XE64	A0A2U3Y499	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.491
FGF9	IL8	A0A2U3X8U2	A0A2U3XEG2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.463
FGF9	PDGFRA	A0A2U3X8U2	A0A2U3YV07	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.910
FGF9	SHH	A0A2U3X8U2	A0A2U3Z6V6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sonic hedgehog protein-like.	0.554
FGF9	TGFB2	A0A2U3X8U2	A0A2U3Y3M9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.454
FGF9	TNF	A0A2U3X8U2	A0A2U3Y499	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.491
FOXF1	SHH	A0A2U3YL06	A0A2U3Z6V6	Forkhead box protein F1.	Sonic hedgehog protein-like.	0.410
FOXF1	TCF21	A0A2U3YL06	A0A2U3Y9R6	Forkhead box protein F1.	Transcription factor 21.	0.402
IL8	FGF10	A0A2U3XEG2	A0A2U3XE64	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
IL8	FGF9	A0A2U3XEG2	A0A2U3X8U2	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.463
IL8	TGFB2	A0A2U3XEG2	A0A2U3Y3M9	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.480
IL8	TNF	A0A2U3XEG2	A0A2U3Y499	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.757
LOC102737096	RARB	A0A2U3YBE1	A0A2U3XWW1	Retinoic acid receptor beta-like.	Retinoic acid receptor beta.	0.899
PDGFRA	FGF10	A0A2U3YV07	A0A2U3XE64	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.913
PDGFRA	FGF9	A0A2U3YV07	A0A2U3X8U2	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.910
PDGFRA	SHH	A0A2U3YV07	A0A2U3Z6V6	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	Sonic hedgehog protein-like.	0.471