(19 nodes) Animal organ formation network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	TBR1	T-box brain protein 1. (682 aa)
	LOC102727270	Uncharacterized protein. (122 aa)
	LOC102733867	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
	NTF4	Neurotrophin-4; Belongs to the NGF-beta family. (211 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	FOXH1	Forkhead box protein H1. (360 aa)
	MEF2C	Myocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	NKX3-2	Homeobox protein Nkx-3.2. (331 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SMARCD3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (435 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LOC102741200	Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	GATA6	Transcription factor GATA-6. (287 aa)
	HOXA3	Homeobox protein Hox-A3. (440 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR1A	LOC102740547	A0A2U3Y9P6	A0A2U3Z034	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4-like isoform X1.	0.994
BMPR1A	NOG	A0A2U3Y9P6	A0A2U3XEL8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.688
FGF10	LOC102740547	A0A2U3XE64	A0A2U3Z034	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4-like isoform X1.	0.769
FGF10	NOG	A0A2U3XE64	A0A2U3XEL8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.791
GATA6	LOC102740547	A0A2U3XNQ5	A0A2U3Z034	Transcription factor GATA-6.	Bone morphogenetic protein 4-like isoform X1.	0.593
GATA6	MEF2C	A0A2U3XNQ5	A0A2U3YMC3	Transcription factor GATA-6.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.455
LOC102740547	BMPR1A	A0A2U3Z034	A0A2U3Y9P6	Bone morphogenetic protein 4-like isoform X1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.994
LOC102740547	FGF10	A0A2U3Z034	A0A2U3XE64	Bone morphogenetic protein 4-like isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.769
LOC102740547	GATA6	A0A2U3Z034	A0A2U3XNQ5	Bone morphogenetic protein 4-like isoform X1.	Transcription factor GATA-6.	0.593
LOC102740547	MEF2C	A0A2U3Z034	A0A2U3YMC3	Bone morphogenetic protein 4-like isoform X1.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.400
LOC102740547	NOG	A0A2U3Z034	A0A2U3XEL8	Bone morphogenetic protein 4-like isoform X1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.992
LOC102740547	WNT11	A0A2U3Z034	A0A2U3YI94	Bone morphogenetic protein 4-like isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.427
MAPK1	MEF2C	A0A2U3YIW0	A0A2U3YMC3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Myocyte-specific enhancer factor 2C-like isoform X2.	0.614
MEF2C	GATA6	A0A2U3YMC3	A0A2U3XNQ5	Myocyte-specific enhancer factor 2C-like isoform X2.	Transcription factor GATA-6.	0.455
MEF2C	LOC102740547	A0A2U3YMC3	A0A2U3Z034	Myocyte-specific enhancer factor 2C-like isoform X2.	Bone morphogenetic protein 4-like isoform X1.	0.400
MEF2C	MAPK1	A0A2U3YMC3	A0A2U3YIW0	Myocyte-specific enhancer factor 2C-like isoform X2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.614
NOG	BMPR1A	A0A2U3XEL8	A0A2U3Y9P6	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.688
NOG	FGF10	A0A2U3XEL8	A0A2U3XE64	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.791
NOG	LOC102740547	A0A2U3XEL8	A0A2U3Z034	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Bone morphogenetic protein 4-like isoform X1.	0.992
WNT11	LOC102740547	A0A2U3YI94	A0A2U3Z034	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Bone morphogenetic protein 4-like isoform X1.	0.427