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SEMA3D SEMA3D SEMA3A SEMA3A SEMA3C SEMA3C ALX1 ALX1 SFRP2 SFRP2 SEMA6D SEMA6D UFL1 UFL1 SNAI2 SNAI2 RET RET ALCAM ALCAM SEMA6C SEMA6C MTF2 MTF2 NOG NOG FOXA1 FOXA1 GREM1 GREM1 PUM1 PUM1 EZH2 EZH2 HMGA2 HMGA2 SEMA3G SEMA3G DMRTA2 DMRTA2 KBTBD8 KBTBD8 LOC102737670 LOC102737670 SETD6 SETD6 HOXA7 HOXA7 GATA6 GATA6 LRP6 LRP6 CORO1C CORO1C SEMA4C SEMA4C HTR2B HTR2B METTL5 METTL5 SMAD4 SMAD4 ACVR1 ACVR1 OSR1 OSR1 GPM6A GPM6A SRF SRF LOC102730452 LOC102730452 SHC4 SHC4 JAG1 JAG1 RDH10 RDH10 WNT8A WNT8A SEMA3F SEMA3F HESX1 HESX1 FOXO4 FOXO4 ITGB1 ITGB1 ECE2 ECE2 TGFB2 TGFB2 NANOG NANOG OTUD5 OTUD5 HIF1A HIF1A ERCC2 ERCC2 TP53 TP53 HOXB4 HOXB4 KITLG KITLG SOX8 SOX8 TBX3 TBX3 HOXD4 HOXD4 SLC9A1 SLC9A1 LOC102741200 LOC102741200 PHACTR4 PHACTR4 PHF5A PHF5A BMPR1A BMPR1A SEMA7A SEMA7A ZNF281 ZNF281 PHOX2B PHOX2B SP7 SP7 ZIC3 ZIC3 SOX17 SOX17 PDCD6 PDCD6 WNT10A WNT10A LOC102745380 LOC102745380 KLHL12 KLHL12 GSC GSC LOC102738010 LOC102738010 BATF BATF ZFP36 ZFP36 MAPK1 MAPK1 SEMA5A SEMA5A MSX1 MSX1 ALDH1A2 ALDH1A2 PSMD11 PSMD11 MEF2C MEF2C LOC102727345 LOC102727345 SEMA6A SEMA6A LOC102726140 LOC102726140 PWWP2A PWWP2A CDX2 CDX2 LOC102729478 LOC102729478 SEMA4G SEMA4G SFRP1 SFRP1 MED1 MED1 JARID2 JARID2 SOX10 SOX10 SEMA6B SEMA6B LOC102745526 LOC102745526 CITED2 CITED2 SOX18 SOX18 ANXA6 ANXA6 LOC102737253 LOC102737253 GBX2 GBX2 LOC102730108 LOC102730108 FGF2 FGF2 SEMA3B SEMA3B SEMA5B SEMA5B LOC102727186 LOC102727186 RADIL RADIL LOC102733867 LOC102733867 LOC102742177 LOC102742177 LOC102745028 LOC102745028 LOC102738078 LOC102738078 SEMA4A SEMA4A FRZB FRZB LOC102737270 LOC102737270
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3DLOW QUALITY PROTEIN: semaphorin-3D; Belongs to the semaphorin family. (781 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (696 aa)
ALX1ALX homeobox protein 1. (326 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SEMA6Dsemaphorin-6D-like isoform X3; Belongs to the semaphorin family. (1017 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (819 aa)
ALCAMCD166 antigen isoform X3. (133 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (963 aa)
MTF2Metal-response element-binding transcription factor 2 isoform X1. (593 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (473 aa)
GREM1Gremlin. (184 aa)
PUM1Pumilio homolog 1 isoform X1. (1188 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (144 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (770 aa)
DMRTA2Doublesex- and mab-3-related transcription factor A2. (540 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (601 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (474 aa)
HOXA7Homeobox protein Hox-A7. (235 aa)
GATA6Transcription factor GATA-6. (287 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CORO1Ccoronin-1C. (303 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
HTR2B5-hydroxytryptamine receptor 2B. (526 aa)
METTL5Methyltransferase-like protein 5 isoform X2. (209 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
OSR1Protein odd-skipped-related 1 isoform X1. (267 aa)
GPM6ANeuronal membrane glycoprotein M6-a. (278 aa)
SRFSerum response factor. (508 aa)
LOC102730452semaphorin-4A-like; Belongs to the semaphorin family. (436 aa)
SHC4SHC-transforming protein 4. (630 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (786 aa)
HESX1Homeobox expressed in ES cells 1. (185 aa)
FOXO4Forkhead box protein O4 isoform X1. (506 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ECE2Endothelin-converting enzyme 2-like isoform X2. (765 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NANOGHomeobox protein NANOG. (226 aa)
OTUD5OTU domain-containing protein 5 isoform X1. (376 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (661 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
HOXB4Homeobox protein Hox-B4. (107 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
SOX8Transcription factor SOX-8. (412 aa)
TBX3T-box transcription factor TBX3. (675 aa)
HOXD4Homeobox protein Hox-D4. (258 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
LOC102741200Exostosin-1-like; Belongs to the glycosyltransferase 47 family. (746 aa)
PHACTR4Phosphatase and actin regulator. (715 aa)
PHF5APHD finger-like domain-containing protein 5A. (110 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
ZNF281Zinc finger protein 281 isoform X1. (892 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
SP7Transcription factor Sp7 isoform X1. (431 aa)
ZIC3Zinc finger protein ZIC 3. (465 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
LOC102745380Histone-lysine N-methyltransferase EZH2-like. (556 aa)
KLHL12Kelch-like protein 12. (568 aa)
GSCHomeobox protein goosecoid. (122 aa)
LOC102738010Uncharacterized protein C17orf96 homolog. (379 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
ZFP36Tristetraprolin. (325 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
SEMA5Asemaphorin-5A-like. (1034 aa)
MSX1Homeobox protein MSX-1. (303 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1047 aa)
LOC102726140Frizzled-1-like; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
PWWP2APWWP domain-containing protein 2A. (755 aa)
CDX2Homeobox protein CDX-2. (311 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (840 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
JARID2Protein Jumonji. (1075 aa)
SOX10Transcription factor SOX-10. (469 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (673 aa)
LOC102745526Neurturin-like. (191 aa)
CITED2Cbp/p300-interacting transactivator 2. (271 aa)
SOX18Transcription factor SOX-18. (186 aa)
ANXA6Annexin. (673 aa)
LOC102737253Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
GBX2Homeobox protein GBX-2. (251 aa)
LOC102730108Neuropilin-1-like. (465 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
SEMA3Bsemaphorin-3B. (166 aa)
SEMA5Bsemaphorin-5B-like. (989 aa)
LOC102727186Heart- and neural crest derivatives-expressed protein 2-like. (217 aa)
RADILRas-associating and dilute domain-containing protein. (1054 aa)
LOC102733867Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102738078Cytochrome P450 26C1-like; Belongs to the cytochrome P450 family. (226 aa)
SEMA4Asemaphorin-4A-like. (350 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
LOC102737270Negative elongation factor B-like. (199 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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