STRINGSTRING
LOC102750752 LOC102750752 EHF EHF LOC102744116 LOC102744116 LOC102727190 LOC102727190 LOC102733867 LOC102733867 LOC102727297 LOC102727297 LOC102726484 LOC102726484 LOC102732257 LOC102732257 LOC102744110 LOC102744110 LOC102731352 LOC102731352 LOC102744822 LOC102744822 NCSTN NCSTN LOC102737660 LOC102737660 LOC102732446 LOC102732446 LOC102746665 LOC102746665 FGF2 FGF2 LOC102741558 LOC102741558 NF1 NF1 BCL2L2 BCL2L2 FERMT1 FERMT1 LOC102740547 LOC102740547 PDX1 PDX1 COL8A2 COL8A2 NOTCH2 NOTCH2 LOC102738536 LOC102738536 IFT57 IFT57 YAP1 YAP1 LOC102743139 LOC102743139 MED1 MED1 LOC102732116 LOC102732116 IGFBP4 IGFBP4 HLX HLX LOC102727345 LOC102727345 MEF2C MEF2C FLCN FLCN LGR5 LGR5 EYA1 EYA1 MAPK1 MAPK1 SDR16C5 SDR16C5 IL6 IL6 COL8A1 COL8A1 MTSS1 MTSS1 IFT80 IFT80 HSF4 HSF4 NKX2-8 NKX2-8 PHOX2B PHOX2B RB1 RB1 TRIM24 TRIM24 BMPR1A BMPR1A OVOL1 OVOL1 AGAP2 AGAP2 PROK2 PROK2 KLK8 KLK8 SFN SFN LOC102739902 LOC102739902 FST FST TNF TNF PTCH1 PTCH1 BAK1 BAK1 PRKX PRKX PHB2 PHB2 ITGB1BP1 ITGB1BP1 NRARP NRARP PPARD PPARD TEK TEK LOC102725913 LOC102725913 LOC102748554 LOC102748554 FGF7 FGF7 THAP1 THAP1 STK4 STK4 B4GALT1 B4GALT1 BMPR2 BMPR2 DLG2 DLG2 CDH13 CDH13 HMX2 HMX2 CDKN1B CDKN1B PROK1 PROK1 LOC102741366 LOC102741366 CLEC12B CLEC12B CEBPB CEBPB SAV1 SAV1 STK3 STK3 ESRP2 ESRP2 LOC102741253 LOC102741253 NOG NOG EREG EREG RETNLB RETNLB FGF10 FGF10 NKX2-6 NKX2-6 NKX3-1 NKX3-1 CAV1 CAV1 BMPER BMPER CD109 CD109 TGFA TGFA WNT16 WNT16 A4GNT A4GNT FGF9 FGF9 LOC102735317 LOC102735317 LGR4 LGR4 HGF HGF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102750752Lysyl oxidase homolog 2-like. (126 aa)
EHFLOW QUALITY PROTEIN: ets homologous factor. (228 aa)
LOC102744116Interferon regulatory factor 6-like. (227 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
LOC102733867Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
LOC102727297LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (336 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
LOC102732257Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (469 aa)
LOC102744110Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
LOC102731352Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
NCSTNNicastrin. (602 aa)
LOC102737660Leucine-rich repeat-containing G-protein coupled receptor 5-like. (315 aa)
LOC102732446ETS homologous factor-like. (118 aa)
LOC102746665SID1 transmembrane family member 2-like. (244 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102741558Bombesin receptor-activated protein C6orf89 homolog isoform X2. (181 aa)
NF1Neurofibromin-like. (1269 aa)
BCL2L2Bcl-2-like protein 2 isoform X1. (193 aa)
FERMT1Fermitin family homolog 1-like. (678 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
COL8A2Collagen alpha-2(VIII) chain. (699 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
LOC102738536Insulin-like growth factor-binding protein 3-like. (120 aa)
IFT57Intraflagellar transport protein 57 homolog. (429 aa)
YAP1Yorkie homolog. (326 aa)
LOC102743139SID1 transmembrane family member 2-like. (615 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
LOC102732116Follicle-stimulating hormone receptor-like. (181 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
HLXH2.0-like homeobox protein. (415 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
FLCNFolliculin. (579 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (598 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
SDR16C5Epidermal retinol dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (237 aa)
IL6Interleukin-6 isoform X1. (212 aa)
COL8A1Collagen alpha-1(VIII) chain isoform X1. (744 aa)
MTSS1Metastasis suppressor protein 1 isoform X3. (529 aa)
IFT80Intraflagellar transport protein 80 homolog. (777 aa)
HSF4Heat shock factor protein 4 isoform X1. (493 aa)
NKX2-8Homeobox protein Nkx-2.8. (239 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
RB1Retinoblastoma-associated protein. (846 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1050 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
OVOL1Putative transcription factor Ovo-like 1. (267 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1189 aa)
PROK2Prokineticin-2 isoform X2. (108 aa)
KLK8Kallikrein-8; Belongs to the peptidase S1 family. (273 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
LOC102739902Uncharacterized protein C1orf172 homolog. (397 aa)
FSTFollistatin isoform X1. (344 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PTCH1Protein patched homolog 1. (1301 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
PHB2Prohibitin. (299 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (200 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
LOC102725913Ras GTPase-activating-like protein IQGAP3-like. (699 aa)
LOC102748554Bombesin receptor-activated protein C6orf89 homolog. (142 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
THAP1THAP domain-containing protein 1. (213 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
B4GALT1Beta-1,4-galactosyltransferase 1-like. (258 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
CDH13Cadherin-13-like. (512 aa)
HMX2Homeobox protein HMX2. (273 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PROK1Prokineticin-1. (105 aa)
LOC102741366Methylosome protein 50-like. (169 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
SAV1Protein salvador homolog 1. (384 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
LOC102741253Amphiregulin-like. (253 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EREGProepiregulin. (292 aa)
RETNLBLOW QUALITY PROTEIN: resistin-like beta. (109 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
NKX2-6Homeobox protein Nkx-2.6. (302 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BMPERBMP-binding endothelial regulator protein-like. (446 aa)
CD109CD109 antigen. (1322 aa)
TGFAProtransforming growth factor alpha. (160 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
A4GNTalpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC102735317Dachshund homolog 1-like. (666 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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