STRINGSTRING
AIMP1 AIMP1 SFRP2 SFRP2 PEX2 PEX2 INTU INTU B2M B2M SNAI2 SNAI2 A4GNT A4GNT ALOX5 ALOX5 CDC73 CDC73 CD109 CD109 BRCA2 BRCA2 CAV2 CAV2 PAX6 PAX6 CAV1 CAV1 VDR VDR APOH APOH NKX3-1 NKX3-1 STK3 STK3 SAV1 SAV1 SULF1 SULF1 LOC102743690 LOC102743690 LOC102737670 LOC102737670 PTEN PTEN LOC102741366 LOC102741366 CDKN1B CDKN1B NUPR1 NUPR1 DLG2 DLG2 SYNJ2BP SYNJ2BP B4GALT1 B4GALT1 STK4 STK4 PDCD10 PDCD10 LOC102732879 LOC102732879 FGFR3 FGFR3 PPARD PPARD ATOH8 ATOH8 PHB2 PHB2 TGFB2 TGFB2 PTCH1 PTCH1 WDR13 WDR13 TNF TNF GHRL GHRL VASH1 VASH1 AQP11 AQP11 LOC102739902 LOC102739902 SFN SFN TINF2 TINF2 IL26 IL26 OVOL1 OVOL1 LOC102736999 LOC102736999 TRIM24 TRIM24 RB1 RB1 PHOX2B PHOX2B NKX2-8 NKX2-8 LECT1 LECT1 GATA3 GATA3 KRT4 KRT4 THBS1 THBS1 IFT80 IFT80 MTSS1 MTSS1 LOC102744863 LOC102744863 DLL4 DLL4 ACVRL1 ACVRL1 TNMD TNMD LOC102749599 LOC102749599 FLCN FLCN MEF2C MEF2C LOC102727345 LOC102727345 LOC102742614 LOC102742614 EPPK1 EPPK1 CDKN2B CDKN2B CDKN2A CDKN2A SLURP1 SLURP1 SFRP1 SFRP1 GDF5 GDF5 MED1 MED1 LOC102735329 LOC102735329 TGFB1 TGFB1 IFT57 IFT57 LOC102731623 LOC102731623 MMRN2 MMRN2 LOC102740250 LOC102740250 PDX1 PDX1 LOC102749531 LOC102749531 LOC102743045 LOC102743045 LOC102740547 LOC102740547 LOC102741947 LOC102741947 NF1 NF1 LOC102727297 LOC102727297 LOC102727190 LOC102727190 LOC102744116 LOC102744116 WNT10B WNT10B LOC102741471 LOC102741471 LOC102736354 LOC102736354
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIMP1Aminoacyl tRNA synthase complex-interacting multifunctional protein 1. (310 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
PEX2Peroxisome biogenesis factor 2 isoform X1. (305 aa)
INTUProtein inturned. (943 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
A4GNTalpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
CDC73Parafibromin. (418 aa)
CD109CD109 antigen. (1322 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog. (2818 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PAX6Paired box protein Pax-6. (221 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
VDRVitamin D3 receptor. (427 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
SAV1Protein salvador homolog 1. (384 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
LOC102743690Aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like. (319 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102741366Methylosome protein 50-like. (169 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
NUPR1Nuclear protein 1 isoform X1. (82 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
B4GALT1Beta-1,4-galactosyltransferase 1-like. (258 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
PDCD10Programmed cell death protein 10 isoform X1. (212 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
ATOH8Protein atonal homolog 8. (318 aa)
PHB2Prohibitin. (299 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTCH1Protein patched homolog 1. (1301 aa)
WDR13WD repeat-containing protein 13 isoform X1. (485 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GHRLAppetite-regulating hormone isoform X1. (117 aa)
VASH1Vasohibin-1. (363 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (272 aa)
LOC102739902Uncharacterized protein C1orf172 homolog. (397 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
TINF2LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (481 aa)
IL26Interleukin-26. (171 aa)
OVOL1Putative transcription factor Ovo-like 1. (267 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1050 aa)
RB1Retinoblastoma-associated protein. (846 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (285 aa)
NKX2-8Homeobox protein Nkx-2.8. (239 aa)
LECT1Leukocyte cell-derived chemotaxin 1. (360 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
KRT4Keratin, type II cytoskeletal 4; Belongs to the intermediate filament family. (530 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
IFT80Intraflagellar transport protein 80 homolog. (777 aa)
MTSS1Metastasis suppressor protein 1 isoform X3. (529 aa)
LOC102744863Uncharacterized protein LOC102744863. (211 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TNMDTenomodulin. (217 aa)
LOC102749599Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (420 aa)
FLCNFolliculin. (579 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
LOC102742614Peripheral plasma membrane protein CASK-like. (818 aa)
EPPK1Epiplakin. (1715 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
SLURP1Secreted Ly-6/uPAR-related protein 1. (126 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
GDF5Growth/differentiation factor 5. (499 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
LOC102735329Vascular endothelial growth factor receptor 1-like. (351 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
IFT57Intraflagellar transport protein 57 homolog. (429 aa)
LOC102731623Serine protease hepsin-like. (82 aa)
MMRN2Multimerin-2-like. (799 aa)
LOC102740250Melanoma-associated antigen D1-like isoform X2. (781 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
LOC102749531Growth/differentiation factor 2-like. (260 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102741947Tenomodulin-like. (164 aa)
NF1Neurofibromin-like. (1269 aa)
LOC102727297LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (336 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
LOC102744116Interferon regulatory factor 6-like. (227 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102741471Parafibromin-like. (141 aa)
LOC102736354ATP synthase subunit alpha, mitochondrial-like. (189 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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