STRINGSTRING
HGF HGF LRFN5 LRFN5 FABP4 FABP4 DUOXA1 DUOXA1 UFL1 UFL1 DUOXA2 DUOXA2 ALOX5 ALOX5 LOC102748411 LOC102748411 TNFAIP8L2 TNFAIP8L2 FAM19A3 FAM19A3 PLA2G10 PLA2G10 TREM2 TREM2 LOC102741936 LOC102741936 NT5E NT5E STAP1 STAP1 PYCARD PYCARD RABGEF1 RABGEF1 NR1H3 NR1H3 PDE2A PDE2A LACC1 LACC1 TMEM173 TMEM173 PTGS2 PTGS2 IGF1 IGF1 BAP1 BAP1 SPATA2 SPATA2 CEBPB CEBPB NAPEPLD NAPEPLD IDO1 IDO1 NFKBIA NFKBIA FAM132A FAM132A SETD6 SETD6 AOAH AOAH MAS1 MAS1 FAM105B FAM105B IL18 IL18 PTGER4 PTGER4 PLA2G3 PLA2G3 GHSR GHSR CCL24 CCL24 ZP3 ZP3 NUPR1 NUPR1 IL10 IL10 SOCS3 SOCS3 NMI NMI TNFAIP6 TNFAIP6 LOC102731157 LOC102731157 IL13 IL13 ASH1L ASH1L TNFSF4 TNFSF4 TNFAIP3 TNFAIP3 IL22RA2 IL22RA2 LETMD1 LETMD1 CCDC142 CCDC142 AKNA AKNA PGLYRP2 PGLYRP2 GPSM3 GPSM3 AGER AGER TYRO3 TYRO3 LOC102738400 LOC102738400 LOC102744024 LOC102744024 PPARD PPARD BCL6 BCL6 NLRP12 NLRP12 FUT7 FUT7 LPCAT3 LPCAT3 TNFRSF1A TNFRSF1A IL2 IL2 CAMK2N1 CAMK2N1 LTA LTA TNF TNF GPR4 GPR4 STAT5B STAT5B GPS2 GPS2 LOC102745783 LOC102745783 GHRL GHRL FANCD2 FANCD2 NDFIP1 NDFIP1 SIGLEC10 SIGLEC10 NLRX1 NLRX1 NKG7 NKG7 IFNG IFNG FEM1A FEM1A LOC102736999 LOC102736999 MKRN2 MKRN2 SEMA7A SEMA7A ETS1 ETS1 RB1 RB1 LGALS2 LGALS2 LGALS1 LGALS1 LOC102725830 LOC102725830 CST7 CST7 GATA3 GATA3 VIMP VIMP TRADD TRADD BST1 BST1 LOC102727117 LOC102727117 MFHAS1 MFHAS1 NLRP6 NLRP6 FFAR4 FFAR4 TRPV4 TRPV4 LOC102729555 LOC102729555 LOC102749969 LOC102749969 NOD2 NOD2 NLRP10 NLRP10 RICTOR RICTOR FFAR2 FFAR2 FOXP3 FOXP3 BCL6B BCL6B NLRC3 NLRC3 AHSG AHSG KARS KARS ZFP36 ZFP36 PTPN2 PTPN2 LDLR LDLR LOC102735415 LOC102735415 FOXF1 FOXF1 NR1D2 NR1D2 AREL1 AREL1 NR1D1 NR1D1 CCR7 CCR7 FANCA FANCA SHARPIN SHARPIN DAGLB DAGLB PROC PROC LOC102749512 LOC102749512 CD28 CD28 PARK7 PARK7 SOCS5 SOCS5 CD47 CD47 S100A9 S100A9 NLRP13 NLRP13 NLRP5 NLRP5 RHBDD3 RHBDD3 PTGES PTGES GPER1 GPER1 LOC102740157 LOC102740157 PIK3AP1 PIK3AP1 PPARA PPARA LOC102730318 LOC102730318 LOC102730527 LOC102730527 MYD88 MYD88 INS INS ADORA2A ADORA2A LOC102734950 LOC102734950 TREX1 TREX1 VPS35 VPS35 STAT5A STAT5A GPR31 GPR31 LOC102744819 LOC102744819 MMP8 MMP8 TWF2 TWF2 LOC102748833 LOC102748833 LOC102744110 LOC102744110 LOC102741358 LOC102741358 DNASE1L3 DNASE1L3 LOC102726994 LOC102726994 LOC102731864 LOC102731864 NLRP9 NLRP9
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
LRFN5Leucine-rich repeat and fibronectin type-III domain-containing protein 5-like. (719 aa)
FABP4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
DUOXA1Dual oxidase maturation factor 1 isoform X1. (342 aa)
UFL1E3 UFM1-protein ligase 1. (792 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
LOC102748411UNC119-binding protein C5orf30 homolog isoform X1. (207 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2. (184 aa)
FAM19A3Protein FAM19A3. (133 aa)
PLA2G10Phospholipase A(2). (163 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
NT5E5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (574 aa)
STAP1Signal-transducing adaptor protein 1. (332 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
RABGEF1Rab5 GDP/GTP exchange factor. (491 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (456 aa)
PDE2APhosphodiesterase. (943 aa)
LACC1Laccase domain-containing protein 1. (118 aa)
TMEM173Stimulator of interferon genes protein. (378 aa)
PTGS2Prostaglandin G/H synthase 2. (470 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
SPATA2Spermatogenesis-associated protein 2. (520 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
NAPEPLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (394 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (394 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
FAM132AProtein FAM132A. (310 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (474 aa)
AOAHLOW QUALITY PROTEIN: acyloxyacyl hydrolase. (533 aa)
MAS1Proto-oncogene Mas isoform X1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
FAM105BUbiquitin thioesterase otulin. (298 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
PLA2G3Group 3 secretory phospholipase A2. (522 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCL24c-C motif chemokine 24. (119 aa)
ZP3Zona pellucida sperm-binding protein 3. (427 aa)
NUPR1Nuclear protein 1 isoform X1. (82 aa)
IL10Interleukin-10. (178 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
NMIN-myc-interactor. (314 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
LOC102731157ARF GTPase-activating protein GIT1-like. (191 aa)
IL13Interleukin-13. (133 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L. (2965 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (231 aa)
LETMD1LETM1 domain-containing protein 1. (360 aa)
CCDC142Coiled-coil domain-containing protein 142. (766 aa)
AKNAAT-hook-containing transcription factor. (789 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase. (605 aa)
GPSM3G-protein-signaling modulator 3 isoform X1. (162 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (845 aa)
LOC102738400Annexin. (345 aa)
LOC102744024Vesicle-associated membrane protein 7-like isoform X1; Belongs to the synaptobrevin family. (220 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
FUT7Alpha-(1,3)-fucosyltransferase 7. (342 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
CAMK2N1Calcium/calmodulin-dependent protein kinase II inhibitor 1. (78 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GPR4G-protein coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
GPS2G protein pathway suppressor 2 isoform X1. (327 aa)
LOC102745783Monoglyceride lipase-like. (113 aa)
GHRLAppetite-regulating hormone isoform X1. (117 aa)
FANCD2Fanconi anemia group D2 protein. (511 aa)
NDFIP1NEDD4 family-interacting protein 1 isoform X1. (221 aa)
SIGLEC10Sialic acid-binding Ig-like lectin 10. (692 aa)
NLRX1NLR family member X1. (975 aa)
NKG7Protein NKG7. (165 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FEM1AProtein fem-1 homolog A isoform X1. (664 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2 isoform X1. (416 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
ETS1Protein C-ets-1-like isoform X1. (441 aa)
RB1Retinoblastoma-associated protein. (846 aa)
LGALS2Galectin. (130 aa)
LGALS1Galectin. (135 aa)
LOC102725830C2 calcium-dependent domain-containing protein 4B-like. (225 aa)
CST7cystatin-F. (153 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
VIMPSelenoprotein S. (188 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
BST1ADP-ribosyl cyclase 2. (312 aa)
LOC102727117Toll-like receptor 10-like; Belongs to the Toll-like receptor family. (809 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1-like. (1052 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (893 aa)
FFAR4Free fatty acid receptor 4. (254 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (742 aa)
LOC102729555oncostatin-M-like. (214 aa)
LOC102749969Interleukin-33-like. (267 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (640 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
FFAR2Free fatty acid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (329 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
BCL6BB-cell CLL/lymphoma 6 member B protein. (476 aa)
NLRC3Protein NLRC3. (330 aa)
AHSGalpha-2-HS-glycoprotein isoform X1. (364 aa)
KARSLysine--tRNA ligase. (625 aa)
ZFP36Tristetraprolin. (325 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
LDLRLow-density lipoprotein receptor. (861 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
FOXF1Forkhead box protein F1. (427 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (576 aa)
AREL1Apoptosis-resistant E3 ubiquitin protein ligase 1. (825 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CCR7c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
FANCAFanconi anemia group A protein. (1453 aa)
SHARPINSharpin isoform X1. (283 aa)
DAGLBSn1-specific diacylglycerol lipase beta. (671 aa)
PROCVitamin K-dependent protein C; Belongs to the peptidase S1 family. (203 aa)
LOC102749512Protein NLRC3-like. (756 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
PARK7Protein DJ-1 isoform X1. (189 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CD47Leukocyte surface antigen CD47. (317 aa)
S100A9Protein S100; Belongs to the S-100 family. (140 aa)
NLRP13NACHT, LRR and PYD domains-containing protein 13. (991 aa)
NLRP5LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 5. (1173 aa)
RHBDD3Rhomboid domain-containing protein 3. (384 aa)
PTGESProstaglandin E synthase. (153 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC102740157Cadherin-5-like; Cadherins are calcium-dependent cell adhesion proteins. (464 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1-like. (410 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102730527Breakpoint cluster region protein-like. (172 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
LOC102734950Forkhead box protein P1-like. (351 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
VPS35Vacuolar protein sorting-associated protein 35. (509 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
GPR3112-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; Belongs to the G-protein coupled receptor 1 family. (313 aa)
LOC102744819Mevalonate kinase-like. (230 aa)
MMP8Neutrophil collagenase. (400 aa)
TWF2Toll-like receptor 9-like isoform X1. (1331 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102744110Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
LOC102741358Protein S100; Belongs to the S-100 family. (89 aa)
DNASE1L3Deoxyribonuclease gamma. (178 aa)
LOC102726994Uracil nucleotide/cysteinyl leukotriene receptor-like; Belongs to the G-protein coupled receptor 1 family. (339 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
NLRP9LOW QUALITY PROTEIN: NLR family, pyrin domain containing 9. (667 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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