(109 nodes) Protein stabilization network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COG3	Conserved oligomeric Golgi complex subunit 3. (886 aa)
	RASSF2	Ras association domain-containing protein 2. (271 aa)
	MCM8	DNA helicase MCM8 isoform X1; Belongs to the MCM family. (833 aa)
	FLNA	filamin-A-like. (1685 aa)
	CRYAB	Alpha-crystallin B chain isoform X1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	TMEM88	Transmembrane protein 88. (159 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	TAF9	Transcription initiation factor TFIID subunit 9-like isoform X1. (265 aa)
	BAG6	Large proline-rich protein BAG6 isoform X1. (1163 aa)
	PIM2	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
	PINK1	Serine/threonine-protein kinase PINK1, mitochondrial. (488 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
	MARCH7	E3 ubiquitin-protein ligase MARCH7. (695 aa)
	STK4	Serine/threonine-protein kinase 4. (487 aa)
	HPS4	Hermansky-Pudlak syndrome 4 protein. (715 aa)
	TSPAN1	Tetraspanin. (241 aa)
	CTNND1	Catenin delta-1 isoform X2. (1022 aa)
	NAA15	N-alpha-acetyltransferase 15, NatA auxiliary subunit. (866 aa)
	CLUL1	Clusterin-like protein 1. (288 aa)
	PHB2	Prohibitin. (299 aa)
	PDCL3	Phosducin-like protein 3. (239 aa)
	BAG1	BAG family molecular chaperone regulator 1. (395 aa)
	EFNA1	ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (266 aa)
	APOA2	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family. (100 aa)
	LOC102743697	Probable ubiquitin carboxyl-terminal hydrolase FAF-X-like. (164 aa)
	LOC102747171	Hsp90 co-chaperone Cdc37-like. (341 aa)
	LOC102751021	Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	LOC102739786	Huntingtin-interacting protein 1-like. (415 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	FBXW9	F-box/WD repeat-containing protein 9. (458 aa)
	LOC102730931	Prolyl 3-hydroxylase 1-like. (349 aa)
	LOC102730835	T-complex protein 1 subunit beta-like. (535 aa)
	WFS1	Wolframin-like. (882 aa)
	CRYAA	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
	LOC102726367	Heat shock protein HSP 90-alpha-like. (262 aa)
	BAG5	BAG family molecular chaperone regulator 5. (448 aa)
	LOC102749901	Gamma-interferon-inducible-lysosomal thiol reductase-like. (252 aa)
	PARK7	Protein DJ-1 isoform X1. (189 aa)
	LOC102736516	Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
	TBRG1	Transforming growth factor beta regulator 1. (411 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (464 aa)
	TTI2	TELO2-interacting protein 2. (508 aa)
	OTUD3	OTU domain-containing protein 3. (395 aa)
	GOLGA7	Golgin subfamily A member 7 isoform X1. (137 aa)
	LOC102740821	Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
	USP13	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
	MORC3	MORC family CW-type zinc finger protein 3. (900 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
	LOC102748459	Prorelaxin-like. (186 aa)
	SYVN1	E3 ubiquitin-protein ligase synoviolin. (612 aa)
	LOC102749952	Lysosomal protein NCU-G1 isoform X1. (406 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	PEX6	Peroxisome assembly factor 2 isoform X1. (980 aa)
	STXBP4	Syntaxin-binding protein 4. (558 aa)
	LOC102744979	DNL-type zinc finger protein-like. (102 aa)
	MSX1	Homeobox protein MSX-1. (303 aa)
	EPHA4	Ephrin type-A receptor 4-like isoform X2. (949 aa)
	PEX19	Peroxisomal biogenesis factor 19 isoform X1. (299 aa)
	SOX17	Transcription factor SOX-17-like. (406 aa)
	TELO2	Telomere length regulation protein TEL2 homolog. (822 aa)
	FAM154A	Protein FAM154A. (410 aa)
	CHEK2	Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
	BAG4	BAG family molecular chaperone regulator 4. (421 aa)
	WDR81	WD repeat-containing protein 81 isoform X1. (1943 aa)
	PIM1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
	LOC102728923	Activating transcription factor 7-interacting protein 1-like. (337 aa)
	LOC102729936	T-complex protein 1 subunit alpha-like. (556 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	PFN2	Profilin; Belongs to the profilin family. (140 aa)
	PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A. (313 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	USP33	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (904 aa)
	DVL1	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
	CCT2	T-complex protein 1 subunit beta. (543 aa)
	CCNH	cyclin-H-like; Belongs to the cyclin family. (344 aa)
	HYPK	Huntingtin-interacting protein K. (121 aa)
	TRIM61	Tripartite motif-containing protein 60. (470 aa)
	NLK	Serine/threonine-protein kinase NLK. (507 aa)
	IGF1	Insulin-like growth factor I isoform X1. (153 aa)
	SAV1	Protein salvador homolog 1. (384 aa)
	CAMLG	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
	COG7	Conserved oligomeric Golgi complex subunit 7. (731 aa)
	CALR	Calreticulin. (417 aa)
	STK3	Serine/threonine-protein kinase 3 isoform X1. (491 aa)
	EP300	Histone acetyltransferase p300. (2425 aa)
	AHSP	Alpha-hemoglobin-stabilizing protein. (92 aa)
	LOC102747519	Tripartite motif-containing protein 60-like. (474 aa)
	LOC102729474	Putative tripartite motif-containing protein 75-like. (469 aa)
	FBXW7	F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
	TAF9B	Transcription initiation factor TFIID subunit 9B. (250 aa)
	LOC102726900	Mothers against decapentaplegic homolog 7-like. (178 aa)
	WRB	Tail-anchored protein insertion receptor WRB. (174 aa)
	BAG2	BAG family molecular chaperone regulator 2. (211 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	NAA16	N-alpha-acetyltransferase 16, NatA auxiliary subunit. (832 aa)
	A1CF	APOBEC1 complementation factor. (592 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
	DSG1	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1052 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	LOC102740002	Glyceraldehyde-3-phosphate dehydrogenase. (290 aa)
	AFM	Afamin. (604 aa)
	CSN3	Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (182 aa)
	USP2	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
	PDCD10	Programmed cell death protein 10 isoform X1. (212 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFM	APOA2	A0A2U3XEI9	P0DM93	Afamin.	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	0.444
APOA1	APOA2	P0DMS4	P0DM93	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	0.999
APOA2	AFM	P0DM93	A0A2U3XEI9	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	Afamin.	0.444
APOA2	APOA1	P0DM93	P0DMS4	Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.999
ATP1B2	ATP1B3	A0A2U3Y5F4	A0A2U3Y1H0	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.934
ATP1B3	ATP1B2	A0A2U3Y1H0	A0A2U3Y5F4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.934
BAG1	BAG2	A0A2U3XT89	A0A2U3XY08	BAG family molecular chaperone regulator 1.	BAG family molecular chaperone regulator 2.	0.960
BAG1	BAG4	A0A2U3XT89	A0A2U3YCN8	BAG family molecular chaperone regulator 1.	BAG family molecular chaperone regulator 4.	0.470
BAG1	BAG5	A0A2U3XT89	A0A2U3YYD5	BAG family molecular chaperone regulator 1.	BAG family molecular chaperone regulator 5.	0.606
BAG2	BAG1	A0A2U3XY08	A0A2U3XT89	BAG family molecular chaperone regulator 2.	BAG family molecular chaperone regulator 1.	0.960
BAG2	BAG4	A0A2U3XY08	A0A2U3YCN8	BAG family molecular chaperone regulator 2.	BAG family molecular chaperone regulator 4.	0.681
BAG2	BAG5	A0A2U3XY08	A0A2U3YYD5	BAG family molecular chaperone regulator 2.	BAG family molecular chaperone regulator 5.	0.876
BAG4	BAG1	A0A2U3YCN8	A0A2U3XT89	BAG family molecular chaperone regulator 4.	BAG family molecular chaperone regulator 1.	0.470
BAG4	BAG2	A0A2U3YCN8	A0A2U3XY08	BAG family molecular chaperone regulator 4.	BAG family molecular chaperone regulator 2.	0.681
BAG5	BAG1	A0A2U3YYD5	A0A2U3XT89	BAG family molecular chaperone regulator 5.	BAG family molecular chaperone regulator 1.	0.606
BAG5	BAG2	A0A2U3YYD5	A0A2U3XY08	BAG family molecular chaperone regulator 5.	BAG family molecular chaperone regulator 2.	0.876
BAG5	TP53	A0A2U3YYD5	A0A2U3Y5G3	BAG family molecular chaperone regulator 5.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.430
CALR	HSP90AB1	A0A2U3XH12	A0A2U3YWF8	Calreticulin.	Heat shock protein HSP 90-beta.	0.715
CALR	LOC102726367	A0A2U3XH12	A0A2U3YZ27	Calreticulin.	Heat shock protein HSP 90-alpha-like.	0.715
CALR	LOC102740821	A0A2U3XH12	A0A2U3YR35	Calreticulin.	Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.	0.493