(24 nodes) Defense response to Gram-negative bacterium network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102740172	Lipopolysaccharide-binding protein-like. (97 aa)
	ROMO1	Reactive oxygen species modulator 1 isoform X1. (79 aa)
	LOC102740077	Optineurin-like. (123 aa)
	IL22RA1	Interleukin-22 receptor subunit alpha-1-like. (379 aa)
	IL17F	interleukin-17F. (157 aa)
	IL17A	interleukin-17A. (155 aa)
	AQP1	Aquaporin-1 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	TNFRSF14	Tumor necrosis factor receptor superfamily member 14. (272 aa)
	CST11	Cystatin-11. (137 aa)
	DEFB1	Beta-defensin 1 isoform X1. (69 aa)
	IL23A	Interleukin-23 subunit alpha. (210 aa)
	ELANE	LOW QUALITY PROTEIN: neutrophil elastase; Belongs to the peptidase S1 family. (284 aa)
	HMGB2	High mobility group protein B2 isoform X1. (210 aa)
	TUSC2	Tumor suppressor candidate 2. (110 aa)
	RNASE7	Ribonuclease 7; Belongs to the pancreatic ribonuclease family. (171 aa)
	RARRES2	Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
	LYPD8	ly6/PLAUR domain-containing protein 8. (256 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	LOC102749618	Toll-like receptor 4-like; Belongs to the Toll-like receptor family. (793 aa)
	LOC102741936	Trem-like transcript 1 protein-like. (128 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	LOC102749211	60S ribosomal protein L30-like. (147 aa)
	DEFB127	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (100 aa)
	DEFB119	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (83 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEFB1	DEFB119	A0A2U3YBZ6	A0A2U3X7V8	Beta-defensin 1 isoform X1.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.717
DEFB119	DEFB1	A0A2U3X7V8	A0A2U3YBZ6	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin 1 isoform X1.	0.717
DEFB119	DEFB127	A0A2U3X7V8	A0A2U3X7X1	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.696
DEFB127	DEFB119	A0A2U3X7X1	A0A2U3X7V8	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.696
HMGB2	LOC102749618	A0A2U3Y1X1	A0A2U3XD09	High mobility group protein B2 isoform X1.	Toll-like receptor 4-like; Belongs to the Toll-like receptor family.	0.498
IL17A	IL17F	A0A2U3YYK4	A0A2U3YYK8	interleukin-17A.	interleukin-17F.	0.982
IL17A	IL22RA1	A0A2U3YYK4	A0A2U3Z0D2	interleukin-17A.	Interleukin-22 receptor subunit alpha-1-like.	0.420
IL17A	IL23A	A0A2U3YYK4	A0A2U3YBV0	interleukin-17A.	Interleukin-23 subunit alpha.	0.579
IL17F	IL17A	A0A2U3YYK8	A0A2U3YYK4	interleukin-17F.	interleukin-17A.	0.982
IL17F	IL23A	A0A2U3YYK8	A0A2U3YBV0	interleukin-17F.	Interleukin-23 subunit alpha.	0.409
IL22RA1	IL17A	A0A2U3Z0D2	A0A2U3YYK4	Interleukin-22 receptor subunit alpha-1-like.	interleukin-17A.	0.420
IL22RA1	IL23A	A0A2U3Z0D2	A0A2U3YBV0	Interleukin-22 receptor subunit alpha-1-like.	Interleukin-23 subunit alpha.	0.866
IL23A	IL17A	A0A2U3YBV0	A0A2U3YYK4	Interleukin-23 subunit alpha.	interleukin-17A.	0.579
IL23A	IL17F	A0A2U3YBV0	A0A2U3YYK8	Interleukin-23 subunit alpha.	interleukin-17F.	0.409
IL23A	IL22RA1	A0A2U3YBV0	A0A2U3Z0D2	Interleukin-23 subunit alpha.	Interleukin-22 receptor subunit alpha-1-like.	0.866
LOC102740172	LOC102749618	A0A2U3Z8B9	A0A2U3XD09	Lipopolysaccharide-binding protein-like.	Toll-like receptor 4-like; Belongs to the Toll-like receptor family.	0.471
LOC102741936	TREM2	A0A2U3XCU2	A0A2U3XCQ7	Trem-like transcript 1 protein-like.	Triggering receptor expressed on myeloid cells 2.	0.742
LOC102749618	HMGB2	A0A2U3XD09	A0A2U3Y1X1	Toll-like receptor 4-like; Belongs to the Toll-like receptor family.	High mobility group protein B2 isoform X1.	0.498
LOC102749618	LOC102740172	A0A2U3XD09	A0A2U3Z8B9	Toll-like receptor 4-like; Belongs to the Toll-like receptor family.	Lipopolysaccharide-binding protein-like.	0.471
TREM2	LOC102741936	A0A2U3XCQ7	A0A2U3XCU2	Triggering receptor expressed on myeloid cells 2.	Trem-like transcript 1 protein-like.	0.742