(34 nodes) Defense response to Gram-positive bacterium network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
	STAB2	Stabilin-2. (335 aa)
	DEFB1	Beta-defensin 1 isoform X1. (69 aa)
	NLRP6	NACHT, LRR and PYD domains-containing protein 6. (893 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
	CARD9	Caspase recruitment domain-containing protein 9-like. (536 aa)
	PLA2G1B	Phospholipase A(2). (146 aa)
	LOC102727255	Nucleoporin SEH1-like; Belongs to the WD repeat SEC13 family. (468 aa)
	TNFRSF14	Tumor necrosis factor receptor superfamily member 14. (272 aa)
	PGLYRP4	Peptidoglycan recognition protein 4. (371 aa)
	IL17A	interleukin-17A. (155 aa)
	IL17F	interleukin-17F. (157 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	ROMO1	Reactive oxygen species modulator 1 isoform X1. (79 aa)
	DEFB119	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (83 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (280 aa)
	RARRES2	Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
	RNASE10	Inactive ribonuclease-like protein 10; Belongs to the pancreatic ribonuclease family. (215 aa)
	RNASE12	Probable inactive ribonuclease-like protein 12; Belongs to the pancreatic ribonuclease family. (145 aa)
	RNASE7	Ribonuclease 7; Belongs to the pancreatic ribonuclease family. (171 aa)
	RNASE11	Probable ribonuclease 11; Belongs to the pancreatic ribonuclease family. (199 aa)
	RNASE9	Inactive ribonuclease-like protein 9; Belongs to the pancreatic ribonuclease family. (201 aa)
	RNASE4	Ribonuclease 4 isoform X1; Belongs to the pancreatic ribonuclease family. (147 aa)
	KLRK1	NKG2-D type II integral membrane protein. (216 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	LYG2	Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (212 aa)
	LYG1	Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (197 aa)
	TNFSF8	Tumor necrosis factor ligand superfamily member 8; Belongs to the tumor necrosis factor family. (234 aa)
	PGLYRP2	N-acetylmuramoyl-L-alanine amidase. (605 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
	HMGB2	High mobility group protein B2 isoform X1. (210 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD9	IL17A	A0A2U3YN36	A0A2U3YYK4	Caspase recruitment domain-containing protein 9-like.	interleukin-17A.	0.467
CARD9	MYD88	A0A2U3YN36	A0A2U3Z302	Caspase recruitment domain-containing protein 9-like.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.601
CARD9	NOD2	A0A2U3YN36	A0A2U3YF51	Caspase recruitment domain-containing protein 9-like.	Nucleotide-binding oligomerization domain-containing protein 2.	0.684
CARD9	TNF	A0A2U3YN36	A0A2U3Y499	Caspase recruitment domain-containing protein 9-like.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.461
DEFB1	DEFB119	A0A2U3YBZ6	A0A2U3X7V8	Beta-defensin 1 isoform X1.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.717
DEFB119	DEFB1	A0A2U3X7V8	A0A2U3YBZ6	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin 1 isoform X1.	0.717
IL17A	CARD9	A0A2U3YYK4	A0A2U3YN36	interleukin-17A.	Caspase recruitment domain-containing protein 9-like.	0.467
IL17A	IL17F	A0A2U3YYK4	A0A2U3YYK8	interleukin-17A.	interleukin-17F.	0.982
IL17A	IL18	A0A2U3YYK4	A0A2U3XPG8	interleukin-17A.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.656
IL17A	KLRK1	A0A2U3YYK4	A0A2U3XL39	interleukin-17A.	NKG2-D type II integral membrane protein.	0.426
IL17A	LTA	A0A2U3YYK4	A0A2U3Y496	interleukin-17A.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.551
IL17A	MYD88	A0A2U3YYK4	A0A2U3Z302	interleukin-17A.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.507
IL17A	NOD2	A0A2U3YYK4	A0A2U3YF51	interleukin-17A.	Nucleotide-binding oligomerization domain-containing protein 2.	0.487
IL17A	TNF	A0A2U3YYK4	A0A2U3Y499	interleukin-17A.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.770
IL17F	IL17A	A0A2U3YYK8	A0A2U3YYK4	interleukin-17F.	interleukin-17A.	0.982
IL17F	IL18	A0A2U3YYK8	A0A2U3XPG8	interleukin-17F.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.404
IL17F	LTA	A0A2U3YYK8	A0A2U3Y496	interleukin-17F.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.454
IL17F	TNF	A0A2U3YYK8	A0A2U3Y499	interleukin-17F.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.560
IL18	IL17A	A0A2U3XPG8	A0A2U3YYK4	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	interleukin-17A.	0.656
IL18	IL17F	A0A2U3XPG8	A0A2U3YYK8	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	interleukin-17F.	0.404