STRINGSTRING
SOCS6 SOCS6 LEF1 LEF1 KIAA0922 KIAA0922 PAG1 PAG1 IL7 IL7 B2M B2M HSPD1 HSPD1 CD300A CD300A FOXJ1 FOXJ1 NCK1 NCK1 TNFRSF21 TNFRSF21 SOX12 SOX12 LOC102741827 LOC102741827 HLX HLX CD40LG CD40LG TBX21 TBX21 PRNP PRNP PTPN2 PTPN2 SLAMF1 SLAMF1 LOC102726821 LOC102726821 FOXP3 FOXP3 LOC102743741 LOC102743741 RASGRP1 RASGRP1 TWSG1 TWSG1 RAC2 RAC2 NOD2 NOD2 PRKAR1A PRKAR1A TFRC TFRC IL12B IL12B CBFB CBFB LOC102739213 LOC102739213 GATA3 GATA3 CD74 CD74 IL23A IL23A EGR3 EGR3 FLOT2 FLOT2 LGALS1 LGALS1 BCL10 BCL10 LOC102739819 LOC102739819 LOC102736999 LOC102736999 IFNG IFNG THY1 THY1 NDFIP1 NDFIP1 TOX TOX LOC102733393 LOC102733393 PRDM1 PRDM1 KITLG KITLG FANCD2 FANCD2 EFNB3 EFNB3 ZBTB1 ZBTB1 ARG2 ARG2 STAT5B STAT5B KAT2A KAT2A AIF1 AIF1 MYB MYB IL21 IL21 IL2 IL2 LOC102750166 LOC102750166 LOC102750454 LOC102750454 LOC102748462 LOC102748462 LOC102747485 LOC102747485 FAM49B FAM49B CD4 CD4 LAG3 LAG3 NRARP NRARP ZC3H8 ZC3H8 PDCD1LG2 PDCD1LG2 NLRP12 NLRP12 BCL6 BCL6 LOC102738400 LOC102738400 FADD FADD TRAF6 TRAF6 CD83 CD83 LOC102726900 LOC102726900 LGALS3 LGALS3 AGER AGER BTNL2 BTNL2 LOC102741082 LOC102741082 LOC102740784 LOC102740784 LOC102729738 LOC102729738 ZBTB16 ZBTB16 LOXL3 LOXL3 SASH3 SASH3 MARCH7 MARCH7 ZMIZ1 ZMIZ1 PAWR PAWR TNFSF4 TNFSF4 LOC102741183 LOC102741183 PRKCQ PRKCQ IRF1 IRF1 DLG2 DLG2 LAT LAT ZP3 ZP3 CORO1A CORO1A ZAP70 ZAP70 CLEC4G CLEC4G IL18 IL18 VSIG4 VSIG4 PRELID1 PRELID1 IFNB1 IFNB1 ZP4 ZP4 PTEN PTEN PRKCZ PRKCZ IDO1 IDO1 FGL2 FGL2 CEBPB CEBPB FOXN1 FOXN1 LAX1 LAX1 IGF1 IGF1 LOC102749335 LOC102749335 CD80 CD80 DHPS DHPS SH3RF1 SH3RF1 CARD11 CARD11 PYCARD PYCARD BMI1 BMI1 FOXO3 FOXO3 GPNMB GPNMB CCDC88B CCDC88B CAV1 CAV1 GLMN GLMN NCKAP1L NCKAP1L PTPN22 PTPN22 TNFAIP8L2 TNFAIP8L2 CBLB CBLB LRRC1 LRRC1 HHLA2 HHLA2 LOC102731864 LOC102731864 WNT10B WNT10B SHH SHH PCK1 PCK1 SLC7A1 SLC7A1 LOC102744110 LOC102744110 LOC102738176 LOC102738176 LOC102745948 LOC102745948 IL4I1 IL4I1 MAPK8IP1 MAPK8IP1 STAT5A STAT5A TREX1 TREX1 IGF2 IGF2 ADORA2A ADORA2A LOC102734456 LOC102734456 PLA2G2F PLA2G2F LOC102740348 LOC102740348 LOC102740547 LOC102740547 LOC102745732 LOC102745732 TNFSF9 TNFSF9 TNFSF14 TNFSF14 LGALS9 LGALS9 TIGIT TIGIT ABL1 ABL1 CRTAM CRTAM NCK2 NCK2 LOC102734445 LOC102734445 AMBRA1 AMBRA1 LEP LEP SLC46A2 SLC46A2 SOCS5 SOCS5 CTLA4 CTLA4 CD28 CD28 ICOS ICOS ZNF683 ZNF683 SIRPB1 SIRPB1 LRRC32 LRRC32 LOC102729386 LOC102729386 TYK2 TYK2 TNFRSF14 TNFRSF14 FANCA FANCA CCR7 CCR7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOCS6Suppressor of cytokine signaling 6. (535 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
KIAA0922Transmembrane protein 131-like. (1601 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (434 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
HSPD160 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (573 aa)
CD300ACMRF35-like molecule 8. (309 aa)
FOXJ1Forkhead box protein J1. (421 aa)
NCK1Cytoplasmic protein. (377 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X1. (651 aa)
SOX12Transcription factor SOX. (314 aa)
LOC102741827ephrin-B1-like; Belongs to the ephrin family. (247 aa)
HLXH2.0-like homeobox protein. (415 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
TBX21T-box transcription factor TBX21. (535 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
SLAMF1Signaling lymphocytic activation molecule. (312 aa)
LOC102726821Galectin. (139 aa)
FOXP3Forkhead box protein P3 isoform X1. (456 aa)
LOC102743741Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
RASGRP1RAS guanyl-releasing protein 1-like isoform X1. (366 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
TFRCTransferrin receptor protein 1 isoform X1. (770 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (279 aa)
CBFBCore-binding factor subunit beta isoform X1. (187 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
IL23AInterleukin-23 subunit alpha. (210 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
LGALS1Galectin. (135 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
LOC102739819Spectrin alpha chain, erythrocytic 1-like. (1472 aa)
LOC102736999Dual specificity protein phosphatase 10-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (177 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
NDFIP1NEDD4 family-interacting protein 1 isoform X1. (221 aa)
TOXThymocyte selection-associated high mobility group box protein TOX. (487 aa)
LOC102733393Protein FAM65B-like. (563 aa)
PRDM1PR domain zinc finger protein 1 isoform X3. (818 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
FANCD2Fanconi anemia group D2 protein. (511 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (340 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa)
ARG2Arginase. (354 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
KAT2AHistone acetyltransferase KAT2A isoform X2. (838 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
MYBTranscriptional activator Myb isoform X1. (761 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
LOC102750166HLA class II histocompatibility antigen, DM beta chain-like. (263 aa)
LOC102750454HLA class II histocompatibility antigen, DM alpha chain-like; Belongs to the MHC class II family. (261 aa)
LOC102748462HLA class II histocompatibility antigen, DO beta chain-like. (273 aa)
LOC102747485HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X2. (329 aa)
FAM49BProtein FAM49B isoform X2. (324 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
LAG3Lymphocyte activation gene 3 protein. (389 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
ZC3H8Zinc finger CCCH domain-containing protein 8. (305 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12. (1059 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
LOC102738400Annexin. (345 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CD83CD83 antigen isoform X1. (199 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
LGALS3Galectin. (285 aa)
AGERAdvanced glycosylation end product-specific receptor. (397 aa)
BTNL2Butyrophilin-like protein 2. (455 aa)
LOC102741082DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC102740784HLA class II histocompatibility antigen, DR alpha chain-like; Belongs to the MHC class II family. (254 aa)
LOC102729738Lysyl oxidase homolog 3-like. (231 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
LOXL3Lysyl oxidase homolog 3-like isoform X1. (392 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7. (695 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (957 aa)
PAWRPRKC apoptosis WT1 regulator protein. (290 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
LOC102741183Roquin-1-like. (688 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IRF1Interferon regulatory factor. (322 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
LATLinker for activation of T-cells family member 1. (256 aa)
ZP3Zona pellucida sperm-binding protein 3. (427 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ZAP70Tyrosine-protein kinase. (616 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4 isoform X1. (399 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial isoform X1. (219 aa)
IFNB1Interferon beta. (182 aa)
ZP4Zona pellucida sperm-binding protein 4 isoform X1. (574 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (394 aa)
FGL2Fibroleukin. (440 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
FOXN1Forkhead box protein N1 isoform X1. (641 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (432 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
LOC102749335E3 ubiquitin-protein ligase CBL-B-like. (139 aa)
CD80LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (872 aa)
CARD11Caspase recruitment domain-containing protein 11. (1146 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
BMI1Polycomb complex protein BMI-1 isoform X1. (326 aa)
FOXO3Forkhead box protein O3. (672 aa)
GPNMBTransmembrane glycoprotein NMB isoform X2. (554 aa)
CCDC88BCoiled-coil domain-containing protein 88B. (1465 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GLMNGlomulin. (521 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (805 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2. (184 aa)
CBLBE3 ubiquitin-protein ligase CBL-B-like. (832 aa)
LRRC1Leucine-rich repeat-containing protein 1. (242 aa)
HHLA2LOW QUALITY PROTEIN: HERV-H LTR-associating 2. (282 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SHHSonic hedgehog protein-like. (286 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
SLC7A1High affinity cationic amino acid transporter 1. (229 aa)
LOC102744110Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
LOC102738176Spectrin alpha chain, erythrocytic 1-like. (1276 aa)
LOC102745948CD27 antigen-like. (261 aa)
IL4I1L-amino-acid oxidase. (386 aa)
MAPK8IP1c-Jun-amino-terminal kinase-interacting protein 1. (669 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
IGF2Insulin-like growth factor II. (138 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
LOC102734456HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
PLA2G2FPhospholipase A(2). (210 aa)
LOC102740348Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102745732Leucine-rich repeat-containing protein 1-like. (92 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (177 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14. (241 aa)
LGALS9Galectin. (364 aa)
TIGITT-cell immunoreceptor with Ig and ITIM domains. (167 aa)
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
CRTAMCytotoxic and regulatory T-cell molecule. (366 aa)
NCK2Cytoplasmic protein. (380 aa)
LOC102734445Phospholipase A(2). (145 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1-like. (299 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
SLC46A2Thymic stromal cotransporter homolog. (475 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
CD28T-cell-specific surface glycoprotein CD28. (209 aa)
ICOSInducible T-cell costimulator. (209 aa)
ZNF683LOW QUALITY PROTEIN: zinc finger protein 683. (472 aa)
SIRPB1Signal-regulatory protein beta-1 isoform 3. (175 aa)
LRRC32Leucine-rich repeat-containing protein 32. (663 aa)
LOC102729386Tyrosine-protein phosphatase non-receptor type substrate 1-like. (359 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14. (272 aa)
FANCAFanconi anemia group A protein. (1453 aa)
CCR7c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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