(71 nodes) Positive regulation of chemotaxis network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	MSTN	Growth/differentiation factor 8. (375 aa)
	DNM1L	Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
	CXCL12	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	SWAP70	Switch-associated protein 70 isoform X1. (585 aa)
	NCKAP1L	Nck-associated protein 1-like. (1134 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	LOC102741936	Trem-like transcript 1 protein-like. (128 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	IL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	RARRES2	Retinoic acid receptor responder protein 2 isoform X1. (163 aa)
	HSPB1	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
	CCL26	C-C motif chemokine. (94 aa)
	CDH13	Cadherin-13-like. (512 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
	F2RL1	Proteinase-activated receptor 2. (415 aa)
	GPSM3	G-protein-signaling modulator 3 isoform X1. (162 aa)
	AGER	Advanced glycosylation end product-specific receptor. (397 aa)
	ZNF580	Zinc finger protein 580. (172 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	NEDD9	Enhancer of filamentation 1 isoform X1. (834 aa)
	S100A14	Protein S100-A14; Belongs to the S-100 family. (104 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	GAS6	Growth arrest-specific protein 6. (646 aa)
	TMEM102	Transmembrane protein 102. (510 aa)
	CCL21	c-C motif chemokine 21. (137 aa)
	CCL19	C-C motif chemokine. (100 aa)
	LOC102733393	Protein FAM65B-like. (563 aa)
	MOSPD2	Motile sperm domain-containing protein 2. (381 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
	IL23A	Interleukin-23 subunit alpha. (210 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (279 aa)
	IL16	Pro-interleukin-16. (480 aa)
	LOC102739213	High mobility group protein B1-like. (214 aa)
	CSF1R	Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
	THBS1	Thrombospondin-1 isoform X1. (1170 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (742 aa)
	RAC2	Ras-related C3 botulinum toxin substrate 2. (192 aa)
	AKIRIN1	Akirin-1. (180 aa)
	CXCL13	c-X-C motif chemokine 13. (110 aa)
	SLAMF1	Signaling lymphocytic activation molecule. (312 aa)
	PPM1F	Protein phosphatase 1F. (287 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	HABP2	Hyaluronan-binding protein 2. (558 aa)
	FGF18	Fibroblast growth factor 18. (116 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
	PGF	Placenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	CCR7	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
	LOC102737831	Serine/threonine-protein kinase D2-like. (246 aa)
	VEGFB	Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	XCL1	Lymphotactin. (112 aa)
	CXCL14	c-X-C motif chemokine 14. (99 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	TGFB1	Transforming growth factor beta-1. (261 aa)
	IL34	Interleukin-34. (236 aa)
	MEGF8	Multiple epidermal growth factor-like domains protein 8. (2068 aa)
	LOC102735431	C-C motif chemokine. (93 aa)
	SCG2	Secretogranin-2. (618 aa)
	STX3	Syntaxin-3; Belongs to the syntaxin family. (285 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14. (241 aa)
	CXCR3	c-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	ANO6	Anoctamin. (800 aa)
	PRSS56	Serine protease 56; Belongs to the peptidase S1 family. (631 aa)
	LOC102740057	Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
	LOC102736544	Thrombospondin-4-like. (685 aa)
	CCR6	c-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	CCR1	c-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	LOC102730129	Uncharacterized protein LOC102730129. (471 aa)
	LOC102750030	Protein-tyrosine kinase 2-beta-like. (125 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	LOC102739213	A0A2U3XY32	A0A2U3YCB6	Advanced glycosylation end product-specific receptor.	High mobility group protein B1-like.	0.720
AIF1	CSF1R	A0A2U3Y493	A0A2U3YD79	Allograft inflammatory factor 1.	Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.436
BMPR2	TGFB1	A0A2U3XT63	A0A2U3YVA3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta-1.	0.587
CCL19	CCL21	A0A2U3Y6I7	A0A2U3Y6G1	C-C motif chemokine.	c-C motif chemokine 21.	0.725
CCL19	CCL26	A0A2U3Y6I7	A0A2U3XRB4	C-C motif chemokine.	C-C motif chemokine.	0.469
CCL19	CCR1	A0A2U3Y6I7	A0A2U3Z4L1	C-C motif chemokine.	c-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.603
CCL19	CCR6	A0A2U3Y6I7	A0A2U3Z436	C-C motif chemokine.	c-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.671
CCL19	CCR7	A0A2U3Y6I7	A0A2U3YRB2	C-C motif chemokine.	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.891
CCL19	CXCL10	A0A2U3Y6I7	A0A2U3YK42	C-C motif chemokine.	C-X-C motif chemokine.	0.609
CCL19	CXCL12	A0A2U3Y6I7	A0A2U3X9U4	C-C motif chemokine.	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family.	0.754
CCL19	CXCL13	A0A2U3Y6I7	A0A2U3YIF7	C-C motif chemokine.	c-X-C motif chemokine 13.	0.783
CCL19	CXCR3	A0A2U3Y6I7	A0A2U3Z0I4	C-C motif chemokine.	c-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family.	0.657
CCL21	CCL19	A0A2U3Y6G1	A0A2U3Y6I7	c-C motif chemokine 21.	C-C motif chemokine.	0.725
CCL21	CCL26	A0A2U3Y6G1	A0A2U3XRB4	c-C motif chemokine 21.	C-C motif chemokine.	0.979
CCL21	CCR1	A0A2U3Y6G1	A0A2U3Z4L1	c-C motif chemokine 21.	c-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.885
CCL21	CCR6	A0A2U3Y6G1	A0A2U3Z436	c-C motif chemokine 21.	c-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.891
CCL21	CCR7	A0A2U3Y6G1	A0A2U3YRB2	c-C motif chemokine 21.	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.997
CCL21	CXCL10	A0A2U3Y6G1	A0A2U3YK42	c-C motif chemokine 21.	C-X-C motif chemokine.	0.986
CCL21	CXCL12	A0A2U3Y6G1	A0A2U3X9U4	c-C motif chemokine 21.	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family.	0.989
CCL21	CXCL13	A0A2U3Y6G1	A0A2U3YIF7	c-C motif chemokine 21.	c-X-C motif chemokine 13.	0.964