(14 nodes) Regulation of membrane protein ectodomain proteolysis network (Leptonychotes weddellii)

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second shell of interactors

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Known Interactions

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Your Input:
	IL10	Interleukin-10. (178 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D. (840 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TIMP3	Metalloproteinase inhibitor 3. (143 aa)
	ADRA2A	alpha-2A adrenergic receptor. (350 aa)
	LOC102743592	Metalloproteinase inhibitor 2-like. (209 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	TIMP4	Metalloproteinase inhibitor 4. (224 aa)
	TIMP1	Metalloproteinase inhibitor 1. (207 aa)
	NRD1	Nardilysin isoform X1; Belongs to the peptidase M16 family. (999 aa)
	LOC102737163	Tyrosine-protein phosphatase non-receptor type 3-like. (442 aa)
	SNX33	Sorting nexin. (570 aa)
	SH3D19	SH3 domain-containing protein 19. (567 aa)
	LOC102736082	Sorting nexin-9-like. (218 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNG	IL10	A0A2U3Y8N2	A0A2U3XRS9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-10.	0.962
IFNG	TIMP1	A0A2U3Y8N2	A0A2U3XLN1	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Metalloproteinase inhibitor 1.	0.441
IFNG	TNF	A0A2U3Y8N2	A0A2U3Y499	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.818
IL10	IFNG	A0A2U3XRS9	A0A2U3Y8N2	Interleukin-10.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.962
IL10	LOC102743592	A0A2U3XRS9	A0A2U3XSB2	Interleukin-10.	Metalloproteinase inhibitor 2-like.	0.442
IL10	TIMP1	A0A2U3XRS9	A0A2U3XLN1	Interleukin-10.	Metalloproteinase inhibitor 1.	0.621
IL10	TNF	A0A2U3XRS9	A0A2U3Y499	Interleukin-10.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.869
LOC102736082	SNX33	A0A2U3Y8W3	A0A2U3YLA2	Sorting nexin-9-like.	Sorting nexin.	0.916
LOC102743592	IL10	A0A2U3XSB2	A0A2U3XRS9	Metalloproteinase inhibitor 2-like.	Interleukin-10.	0.442
LOC102743592	TIMP1	A0A2U3XSB2	A0A2U3XLN1	Metalloproteinase inhibitor 2-like.	Metalloproteinase inhibitor 1.	0.643
LOC102743592	TIMP3	A0A2U3XSB2	A0A2U3XYC6	Metalloproteinase inhibitor 2-like.	Metalloproteinase inhibitor 3.	0.437
LOC102743592	TNF	A0A2U3XSB2	A0A2U3Y499	Metalloproteinase inhibitor 2-like.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.470
SNX33	LOC102736082	A0A2U3YLA2	A0A2U3Y8W3	Sorting nexin.	Sorting nexin-9-like.	0.916
TIMP1	IFNG	A0A2U3XLN1	A0A2U3Y8N2	Metalloproteinase inhibitor 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.441
TIMP1	IL10	A0A2U3XLN1	A0A2U3XRS9	Metalloproteinase inhibitor 1.	Interleukin-10.	0.621
TIMP1	LOC102743592	A0A2U3XLN1	A0A2U3XSB2	Metalloproteinase inhibitor 1.	Metalloproteinase inhibitor 2-like.	0.643
TIMP1	TNF	A0A2U3XLN1	A0A2U3Y499	Metalloproteinase inhibitor 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.581
TIMP3	LOC102743592	A0A2U3XYC6	A0A2U3XSB2	Metalloproteinase inhibitor 3.	Metalloproteinase inhibitor 2-like.	0.437
TNF	IFNG	A0A2U3Y499	A0A2U3Y8N2	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.818
TNF	IL10	A0A2U3Y499	A0A2U3XRS9	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interleukin-10.	0.869